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negatively regulates Wnt signaling by binding to the PDZ domain [RGD, Feb 2006].. Additionally we are shipping CXXC Finger Protein 4 Antibodies (53) and many more products for this protein.
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IDAX depletion prevents TET2 downregulation in differentiating mouse embryonic stem cells
Age of patients and levels of CXXC4 mRNA, hemoglobin, and marrow blast associated with survival of Myelodysplastic syndrome patients.
EZH2 (show EZH2 Proteins) can activate MAPK (show MAPK1 Proteins) signaling by inhibiting CXXC4 expression.
CXXC4 is a novel potential tumor suppressor directly regulated by EZH2 (show EZH2 Proteins), and its expression is a significant prognosis factor for patients with early stages of gastric cancer.
IDAX expression results in caspase activation and TET2 protein downregulation, in a manner that depends on DNA binding through the IDAX CXXC domain, suggesting that IDAX recruits TET2 to DNA before degradation
Decreased CXXC4 was associated with kidney cancer metastasis, poor survival, beta-catenin (show CTNNB1 Proteins) translocation, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involed in proliferation, invasion, and cell survival.
Idax functions are dependent on the canonical Wnt (show WNT2 Proteins) pathway and are crucial for the anterior neural development
negatively regulates Wnt signaling by binding to the PDZ domain
CXXC-type zinc finger protein 4
, inhibition of the Dvl and axin complex protein
, CXXC finger 4
, Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex)
, inhibitor of the Dvl and Axin complex