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May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Additionally we are shipping CXXC Finger Protein 5 Antibodies (29) and many more products for this protein.
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The Dishevelled (show DVL2 Proteins)-binding protein CXXC5 negatively regulates cutaneous wound healing.
CXXC5 is a transcriptional activator for Flk-1, mediating BMP signaling for differentiation and migration of endothelial cell and vessel formation.
High CXXC5 expression seems to affect several steps in human leukemogenesis, including intracellular events as well as extracellular communication.
Findings suggest that overexpression of CXXC5 in C2C12 myoblasts facilitated myocyte differentiation, while RNAi interference of CXXC5 significantly inhibited the differentiation of C2C12 myoblasts.
Low CXXC5 expression is associated with acute myeloid leukemia (show BCL11A Proteins).
targeting of CXXC5/RINF should be considered as a possible therapeutic strategy, especially in high-risk patients who show increased expression in AML (show RUNX1 Proteins) cells compared with normal hematopoietic cells
Lack of promoter hypermethylation or somatic mutations are found in the potential tumor suppressor CXXC5 in myelodysplastic syndromes or acute myeloid leukemia (show BCL11A Proteins) with deletion 5q.
RINF overexpression represents an independent molecular marker for poor prognosis in breast tumors.
RINF expression correlates with retinoid-induced differentiation of leukemic cells and with cytokine-induced myelopoiesis of normal CD34 (show CD34 Proteins)(+) progenitors.
These findings suggest that CF5 plays a crucial role in ATM (show ATM Proteins)-p53 (show TP53 Proteins) signaling in response to DNA damage.
May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity).
CXXC-type zinc finger protein 5
, CXXC finger 5 protein
, WT1-induced Inhibitor of Dishevelled
, putative MAPK-activating protein PM08
, putative NF-kappa-B-activating protein 102
, retinoid-inducible nuclear factor
, CXXC finger 5