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CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles.
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Rat (Rattus) Polyclonal CADPS Primary Antibody for WB - ABIN1742520
Vogl, Cooper, Neef, Wojcik, Reim, Reisinger, Brose, Rhee, Moser, Wichmann: Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells. in Journal of cell science 2015
the p (show CAPS Antibodies)referential binding of CAPS1 to open syntaxin-1 can (show STX1A Antibodies) contribute to the stabilization of the open state of syntaxi (show UNC13A Antibodies)n-1 during its transition from "closed" state to the SNA (show STX1A Antibodies)RE complex formation.
Increased level of CADPS protein, human in Schizophrenic patients
Loss of CADPS is associated with central nervous system primitive neuroectodermal tumor.
Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor (show DRD2 Antibodies) and calcium-dependent activator protein for secretion (CAPS (show CAPS Antibodies)).
identified a specific interaction of CAPS1 (show CAPS Antibodies) with septin (show SEPT6 Antibodies) family proteins; demonstrated that the C-terminal region of the CAPS1 (show CAPS Antibodies) protein binds to part of the deduced GTP-binding (show RND2 Antibodies) domain of septin (show SEPT6 Antibodies) proteins.
data indicate that CAPS-1 promotes fusion competence of immobile (tethered) DCVs in presynaptic terminals and that CAPS-1 localization to DCVs is probably not essential for this role
Naturally occurring splice variants of CAPS2 (show CADPS2 Antibodies) in CAPS1/CAPS2-deficient cells were studied and found that CAPS2 (show CADPS2 Antibodies) primes vesicles independently of its MUN domain.
Loss of CAPS1 (show CAPS Antibodies) disrupts the trans-Golgi network-dense-core vesicle pathway.
CAPS1 (show CAPS Antibodies) binds to the full-length of cytoplasmic syntaxin-1 (show STX1A Antibodies) with preference to its "open" conformation, whereas Munc13-1 (show UNC13A Antibodies) binds to the first 80 N-terminal residues of syntaxin-1 (show STX1A Antibodies).
CAPS (show CAPS Antibodies) family proteins exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis
a functional role for CAPS1 (show CAPS Antibodies) in regulating DCV trafficking in the trans-Golgi network; this activity occurs via protein-protein interaction with ARF4 (show ARF4 Antibodies)/ARF5 (show ARF5 Antibodies) in a GDP-dependent manner.
CAPS1 (show CAPS Antibodies) has a role in constitutive and regulated exocytosis but not in loading of transmitters into dense core vesicles
Data demonstrate that CAPS-1 and -2 generate and maintain a highly fusion competent synaptic vesicle pool that supports phasic Ca(2 (show CA2 Antibodies)+) triggered release of transmitters.
Although CAPS1 (show CAPS Antibodies) proteins are not required for Ca(2 (show CA2 Antibodies)+)-dependent exocytosis to proceed, they exert a modulatory effect on insulin (show INS Antibodies) granule priming, exocytosis, and stability.
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.
Ca2+-dependent secretion activator
, Ca++-dependent secretion activator
, calcium-dependent secretion activator 1
, Ca2+-dependent activator protein for secretion
, Ca2+-regulated cytoskeletal protein
, calcium-dependent activator protein for secretion 1
, Ca2+-dependent activator protein
, Ca<2+-dependent activator protein for secretion
, Ca<2+>dependent activator protein for secretion