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CDH20 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. Additionally we are shipping Cadherin 20 Antibodies (48) and Cadherin 20 Proteins (8) and many more products for this protein.
Melanoma cell lines contained transcripts for cadherin-7 but not for cadherin-20.
This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes.
, F-cadherin short isoform