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Cadherin 5 Proteins (CDH5)

CDH5 is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. Additionally we are shipping Cadherin 5 Antibodies (228) and Cadherin 5 Kits (63) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CDH5 12562 P55284
CDH5 307618  
CDH5 1003 P33151
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Top Cadherin 5 Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag,Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Rat His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$651.20
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$809.60
Details

CDH5 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
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Rat (Rattus) ,
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Human , , ,
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Top referenced Cadherin 5 Proteins

  1. Human Cadherin 5 Protein expressed in Human Cells - ABIN2002841 : Angst, Marcozzi, Magee: The cadherin superfamily: diversity in form and function. in Journal of cell science 2001 (PubMed)
    Show all 5 references for ABIN2002841

  2. Mouse (Murine) Cadherin 5 Protein expressed in Human Cells - ABIN2007491 : Duguay, Foty, Steinberg: Cadherin-mediated cell adhesion and tissue segregation: qualitative and quantitative determinants. in Developmental biology 2003 (PubMed)
    Show all 5 references for ABIN2007491

  3. Rat (Rattus) Cadherin 5 Protein expressed in Human Cells - ABIN2009411 : Bayas, Leung, Evans, Leckband: Lifetime measurements reveal kinetic differences between homophilic cadherin bonds. in Biophysical journal 2006 (PubMed)
    Show all 4 references for ABIN2009411

More Proteins for Cadherin 5 (CDH5) Interaction Partners

Mouse (Murine) Cadherin 5 (CDH5) interaction partners

  1. Galphas (show GNAS Proteins) depletion blocks the S1PR1 (show S1PR1 Proteins)-activation induced VE-cadherin stabilization at junctions.

  2. Rab11a/Rab11 (show RAB11A Proteins) family-interacting protein 2 (show RAB11FIP2 Proteins)-mediated VE-cadherin recycling is required for formation of adherens junctions and restoration of vascular endothelial barrier integrity.

  3. These findings together demonstrate the essential role of KDM4A (show KDM4A Proteins) and KDM4C (show KDM4C Proteins) in orchestrating mESC differentiation to endothelial cells through the activation of Flk1 (show KDR Proteins) and VE-cadherin promoters, respectively

  4. In the absence of Tie-2 (show TEK Proteins), VE-PTP (show PTPRB Proteins) inhibition destabilizes endothelial barrier integrity in agreement with the VE-cadherin-supportive effect of VE-PTP (show PTPRB Proteins).

  5. identification of novel components of the adherens junction complex, and introduction of a novel molecular mechanism through which the VE-cadherin complex controls YAP (show YAP1 Proteins) transcriptional activity

  6. Endotoxin challenge initiates interrelated changes in microvessel Cx43 (show GJA1 Proteins), VE-cadherin, and microvessel permeability, with changes in Cx43 (show GJA1 Proteins) temporally leading the other responses.

  7. Mutating Y731 in the cytoplasmic tail of VE-cadherin, known to selectively affect leukocyte diapedesis, but not the induction of vascular permeability, attenuates bleeding.

  8. mRNA of HIF-2alpha (show EPAS1 Proteins) and Ets-1 (show ETS1 Proteins) were significantly increased by HIF-3alpha ablation. Both factors activate the VE-cadherin gene, the transcriptional repression of these factors by HIF-3alpha is important for silencing the irrelevant expression of the VE-cadherin

  9. iPS (show SLC27A4 Proteins) cell-derived Flk1 (show KDR Proteins)(+)VE-cadherin(+) cells expressing the Er71 (show ETV2 Proteins) are as angiogenic as mES (show PTCH1 Proteins) cell-derived cells and incorporate into CD31 (show PECAM1 Proteins)(+) neovessels.

  10. VE-cadherin tyrosine phosphorylation at Y685 is a physiological and hormonally regulated process in female reproductive organs.

Zebrafish Cadherin 5 (CDH5) interaction partners

  1. VE-cadherin/amotL2 (show AMOTL2 Proteins) complex is responsible for transmitting mechanical force between endothelial cells for the coordination of cellular morphogenesis consistent with aortic lumen expansion and function.

  2. Cdh5 organizes junctional and cortical actin cytoskeletons and F-actin polymerization during endothelial cell elongation.

  3. Regulatory pathways affecting vascular stabilization via VE-cadherin dynamics

  4. suggest that Ve-cadherin and Moesin1 (show MSN Proteins) function to establish and maintain apical/basal polarity during multicellular lumen formation in the intersegmental vessels

  5. results demonstrate a significant role for VE-cadherin in cardiac development independent of its effects on the formation of the peripheral vasculature

  6. fli1 (show FLI1 Proteins), and etsrp (show ETV2 Proteins), demonstrated that erg (show KCNH2 Proteins) and fli1 (show FLI1 Proteins) act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin

  7. VE-cadherin plays an essential role in vascular development

Human Cadherin 5 (CDH5) interaction partners

  1. BMP-dependent physical interaction of VE-cadherin with the BMP receptor (show BMPR1A Proteins) ALK2 (show ACRV1 Proteins) (BMPRI) and BMPRII (show BMPR2 Proteins), resulting in stabilization of the BMP receptor (show BMPR1A Proteins) complex and, thereby, the support of BMP6 (show BMP6 Proteins)-Smad (show SMAD1 Proteins) signaling.

  2. S-nitrosylation regulates endothelial cell VE-cadherin phosphorylation and internalization in microvascular permeability.

  3. Data indicate that monoclonal antibody (mAb) against vascular endothelial cadherin 5 (VECDH5) has good binding ability and specificity.

  4. Rab11a/Rab11 (show RAB11A Proteins) family-interacting protein 2 (show RAB11FIP2 Proteins)-mediated VE-cadherin recycling is required for formation of adherens junctions and restoration of vascular endothelial barrier integrity.

  5. our data show the importance of spatio-temporal regulation of the actin cytoskeleton through Trio (show TRIO Proteins) and Rac1 at VE-cadherin-based cell-cell junctions in the maintenance of the endothelial barrier.

  6. ankyrin-G associates with and inhibits the endocytosis of VE-cadherin cis (show CISH Proteins) dimers.

  7. VE-cadherin complexes are central force transducers in endothelial barrier in response to force.

  8. Demonstrate that TrkB (show NTRK2 Proteins) protects endothelial integrity during atherogenesis by promoting Ets1 (show ETS1 Proteins)-mediated VE-cadherin expression and plays a previously unknown protective role in the development of coronary artery disease.

  9. homophilic interactions of VE-cadherin stabilize it at cell borders and prevent entry into the lateral border recycling compartment.

  10. The number of CD34 (show CD34 Proteins)/144 positive circulating endothelial cells was high in patients with large artery atherosclerosis who experienced chronic ischemic stroke. And this number may reflect severity of carotid atherosclerosis.

Cow (Bovine) Cadherin 5 (CDH5) interaction partners

  1. VE-cadherin induces opposing growth signals.

  2. investigated the role of catenin p120 (show CTNND1 Proteins)-VE-cadherin interaction in regulation of barrier function in confluent endothelial monolayers

  3. Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA (show RHOA Proteins)

  4. a VE-cadherin-dependent pathway may link T2-TrpRS (show WARS Proteins) to inhibition of new blood vessel formation

  5. results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network

  6. exposure of BAECs to hydrostatic pressure (PHYSIOLOGIC PRESSURE) may downregulate the expression of VE-cadherin, resulting in loss of contact inhibition followed by increased proliferation and formation of a multilayered structure

  7. In all, these results demonstrate that cell-cell contact signals through VE-cadherin, RhoA, and intracellular tension in the actin cytoskeleton to regulate proliferation.

Pig (Porcine) Cadherin 5 (CDH5) interaction partners

  1. Low expressions of eNOS3 and Ve-cadherin in the salvaged sub-healthy microvascular endothelium of infarcted and marginal areas suggest that endothelial system is impaired at 7-day of reperfused acute myocardial infarction.

Cadherin 5 (CDH5) Protein Profile

Protein Summary

This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.

Gene names and symbols associated with Cadherin 5 Proteins (CDH5)

  • cadherin 5, type 2 (vascular endothelium) (CDH5)
  • cadherin 5 (Cdh5)
  • cadherin 5 (cdh5)
  • cadherin 5, type 2 (vascular endothelium) (Cdh5)
  • 7B4 protein
  • AA408225 protein
  • cadherin-5 protein
  • CD144 protein
  • VE-Cad protein
  • Vec protein
  • VEcad protein
  • VECD protein
  • wu:fc88a07 protein

Protein level used designations for Cadherin 5 Proteins (CDH5)

cadherin 5, type 2, VE-cadherin (vascular endothelium) , cadherin 5, type 2, VE-cadherin (vascular epithelium) , 7B4/cadherin-5 , VE-cadherin , cadherin-5 , vascular endothelial cadherin , VE-cadherin (vascular epithelium) , fc88a07 , type 2 , vecdn , 7B4 antigen , cd144 antigen , endothelial-specific cadherin , VE cadherin

GENE ID SPECIES
467991 Pan troglodytes
12562 Mus musculus
307618 Rattus norvegicus
445471 Danio rerio
1003 Homo sapiens
414735 Bos taurus
100727685 Cavia porcellus
414737 Sus scrofa
489775 Canis lupus familiaris
374068 Gallus gallus
101107462 Ovis aries
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