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Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Additionally we are shipping CACNA1D Kits (8) and CACNA1D Proteins (8) and many more products for this protein.
Showing 10 out of 129 products:
Human Monoclonal CACNA1D Primary Antibody for ICC, IF - ABIN361761
Johnson, Marcotti: Biophysical properties of CaV1.3 calcium channels in gerbil inner hair cells. in The Journal of physiology 2008
Show all 2 references for ABIN361761
Human Monoclonal CACNA1D Primary Antibody for ICC, IF - ABIN361760
Zhang, He, Tuteja, Xu, Timofeyev, Zhang, Glatter, Xu, Shin, Low, Chiamvimonvat: Functional roles of Cav1.3(alpha1D) calcium channels in atria: insights gained from gene-targeted null mutant mice. in Circulation 2005
Show all 2 references for ABIN361760
Human Polyclonal CACNA1D Primary Antibody for IF (p), IHC (p) - ABIN751333
Lobeck, Donnelly, Dupree, Mahe, McNeal, Mohanty, Tiao: Rhesus rotavirus VP6 regulates ERK-dependent calcium influx in cholangiocytes. in Virology 2016
Mutations in zebrafish cav1.3a underlie the auditory-vestibular defects of gemini (gem) circler mutants. gem mutant hair cells display normal cell viability, afferent synaptogenesis, and peripheral innervation, yet exhibit reduced extracellular potentials
new information on the hypothalamic expression of alpha1A and alpha1D subunits during development in a mammal with a long gestation period and a large and convoluted brain.
E2 upregulated the expression of Cav1.3 for Ca2 (show CA2 Antibodies)+ influx to promote the expression of p-ERK1/2 (show MAPK1/3 Antibodies) for cell proliferation in breast cancer cells
LRP1B (show LRP1B Antibodies), BRD2 (show BRD2 Antibodies) and CACNA1D are new candidate genes in fetal metabolic programming of newborns exposed to maternal hyperglycemia.
CACNA1D might not be a risk gene for SCZ in Han Chinese population, which add to the current state of knowledge regarding the susceptibility of CACNA1D to schizophrenia.
patients with CACNA1D mutations displayed characteristics similar to wild-type aldosterone-producing adenomas
Studies indicate the function of L-type calcium channels Cav1.3 in chromaffin cells.
Studies indicate a role for L-type calcium channel Cav1.3 and Cav1.4 in cochlear inner hair cells (IHCs) and retinal photoreceptors (PRs).
Mutations in CACNA1D gene is associated with aldosterone-producing adenomas.
Different mutations (KCNJ5 (show KCNJ5 Antibodies), ATP1A1 (show ATP1A1 Antibodies), ATP2B3 (show ATP2B3 Antibodies), and CACNA1D) are found in different aldosterone-producing nodules from the same adrenal, suggesting that somatic mutations are independent events triggered by mechanisms that remain to be identified.
Study found that two de novo CACNA1D missense mutations affect evolutionary highly conserved regions in the channel's activation gate and disrupt normal channel activity by inducing a pronounced gain of channel function
In overall, we provide evidence that Cav1.2 (show CACNA1C Antibodies) and Cav1.3 isoforms are capable of potentially functioning as zinc permeation routes, through which zinc entry can be differentially augmented by mild acidifications.
beta-Adrenergic stimulation enhanced pacemaking of both genotypes, though, Cav1.3(-/-) sino-atrial node cells remained slower than wild type
implicating Cav1.3 as an essential element for hippocampus-associated cognitive functions
Data suggest that the ion channels CaV1.3, bestrophin-1 (show BEST1 Antibodies) and maxiK (show KCNMA1 Antibodies) were identified as players in the regulation of photoreceptor outer segments (POS) phagocytosis by the retinal pigment epithelium (RPE (show RPE Antibodies)).
Cp8 is a new of Cav1.2 (show CACNA1C Antibodies) and Cav1.3 channel activators.
RIM2alpha and RIM2beta promote a large complement of synaptic CaV1.3 Ca(2 (show CA2 Antibodies)+) channels at inner hair cell presynaptic active zones and are required for normal hearing.
Results indicate that the Cav1.3 subtype is crucial to regulation of basal single-spike firing, while activation of both Cav1.2 (show CACNA1C Antibodies) and Cav1.3 can support burst firing of dopaminergic VTA neurons.
ablation of Cav1.3 results in a decrease in the protein expression of myosin light chain 2 (show MYL12B Antibodies), which interacts and increases the membrane localization of SK2 (show PAPSS2 Antibodies) channels.
These data demonstrate that type 1 diabetic serum hyperactivates both CaV1.2 (show CACNA1C Antibodies) and CaV1.3 channels by increasing their conductivity and number.
Cav1.3 significantly upregulated in brain 24hr after single nicotine injection; Cav1.2 (show CACNA1C Antibodies) expression was not significantly altered; downregulation of Cav1.2 (show CACNA1C Antibodies) 24hr after chronic nicotine administration; strong upregulation of Cav1.2 (show CACNA1C Antibodies) following 7-day abstinence
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.
L-type calcium channel pore subunit isoform 1.3a
, voltage-dependent L-type calcium channel subunit alpha-1D
, voltage-gated calcium channel alpha 1D subunit
, calcium channel, voltage-dependent, L type, alpha 1D subunit
, voltage-gated calcium channel subunit Cav1.3
, calcium channel voltage-dependent L type Cav1.3, alpha 1d subunit
, voltage-dependent L-type calcium channel subunit alpha-1D-like
, calcium channel, L type, alpha-1 polypeptide
, calcium channel, neuroendocrine/brain-type, alpha 1 subunit
, voltage-gated calcium channel alpha 1 subunit
, voltage-gated calcium channel alpha subunit Cav1.3
, brain class D
, calcium channel alpha-1 subunit
, voltage-dependent calcium channel subunit alpha1D
, voltage-gated calcium channel pore forming subunit CaV1.3alpha1 IVS3-IVS4 extracellular linker
, voltage-gated calcium channel subunit alpha Cav1.3
, alpha 1 E
, L-type voltage-gated calcium channel alpha1D subunit ChCaChA1D