You are viewing an incomplete version of our website. Please click to reload the website as full version.

Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit Proteins (CACNA1F)

CACNA1F encodes a member of the alpha-1 subunit family\; a protein in the voltage-dependent calcium channel complex. Additionally we are shipping Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit Antibodies (24) and Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CACNA1F 54652  
CACNA1F 778 O60840
Rat CACNA1F CACNA1F 114493  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit Proteins at antibodies-online.com

Showing 3 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CACNA1F Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit (CACNA1F) Interaction Partners

Zebrafish Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit (CACNA1F) interaction partners

  1. CACNA1F exhibited small spot-like staining beneath the RIM2 (show RIMS2 Proteins) and RIBEYE (show CTBP2 Proteins) structures.

Mouse (Murine) Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit (CACNA1F) interaction partners

  1. analysis of Cav1.4 complexes alpha11.4, beta2, and alpha2delta4 in HEK293T cells and in mouse retina

  2. CaBP4 (show CABP4 Proteins) forms a collapsed structure around the IQ motif in Cav1.4 that may promote channel activation by disrupting an interaction between IQ and the inhibitor of Ca(2 (show CA2 Proteins)+)-dependent inactivation domain

  3. the importance of proper Cav (show CA5A Proteins) 1.4 function for efficient PR synapse maturation, and that dysregulation of Cav (show CA5A Proteins) 1.4 channels in CSNB2 may have synaptopathic consequences

  4. model for vision impairment with Cav1.4 mutation

  5. Data on Cav1.4 deficient mice and human female carriers of mutations in CACNA1F are consistent with a phenotype of mosaic congenital stationary night blindness type 2A.

  6. In the absence of the CaV1.4 channel, photoreceptor synapses remain immature and are unable to stabilize.

  7. Complex regulation of voltage-dependent activation and inactivation properties of retinal voltage-gated Cav1.4 L-type Ca2 (show CA2 Proteins)+ channels by Ca2 (show CA2 Proteins)+-binding protein 4 (CaBP4 (show CABP4 Proteins)).

  8. Proper targeting of synaptic proteins and PMCAs to photoreceptor terminals requires adequate expression of Cav1.4 subunit.

  9. Cacna1f ( G305X ) is a true knockout model for human congenital stationary night blindness 2 (CSNB2), with prominent defects in cone and rod function. Cacna1f ( nob2 ) is an incomplete knockout model for CSNB2.

  10. These findings in the Cacna1f-mutant mouse reveal that the Ca(v)1.4 calcium channel is vital for the functional assembly and/or maintenance and synaptic functions of photoreceptor ribbon synapses.

Human Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit (CACNA1F) interaction partners

  1. Studies indicate a role for L-type calcium channel Cav1.3 and Cav1.4 in cochlear inner hair cells (IHCs) and retinal photoreceptors (PRs).

  2. a single nucleotide change c.1555C>T in exon 13 of the CACNA1F gene, leading to the substitution of arginine by tryptophan (p.R519W) in a Chinese individual affected by retinitis pigmentosa, is identified.

  3. novel heterozygous missense mutation (c.1555C>T, p.R519W) in CACNA1F gene, which is probably associated with XLRP.

  4. analysis of Cav1.4 complexes alpha11.4, beta2, and alpha2delta4 in HEK293T cells and in mouse retina

  5. Data on Cav1.4 deficient mice and human female carriers of mutations in CACNA1F are consistent with a phenotype of mosaic congenital stationary night blindness type 2A.

  6. Mutation in Cav1.4 gene is associated with congenital stationary night blindness type 2.

  7. Our data independently confirm CACNA1F as the causative gene for CORDX3-like phenotypes and detailed clinical characterization of the family expands the knowledge about the phenotypic spectrum of deleterious CACNA1F alterations.

  8. In 55 male patients with Congenital Stationary Night Blindness 2, we identified 26 pathogenic sequence changes in the CACNA1F gene. Seventeen of these were novel, 14 of these mutations were nonsense or frameshift mutations, and 3 were missense mutations.

  9. This is the first case report describing outer retinal structural anomaly consistent with abnormal bipolar cell synapses in CACNA1F-related disease.

  10. Complex regulation of voltage-dependent activation and inactivation properties of retinal voltage-gated Cav1.4 L-type Ca2 (show CA2 Proteins)+ channels by Ca2 (show CA2 Proteins)+-binding protein 4 (CaBP4 (show CABP4 Proteins)).

Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit (CACNA1F) Protein Profile

Protein Summary

This gene encodes a member of the alpha-1 subunit family\; a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been shown to cause incomplete X-linked congential stationary night blindness type 2 (CSNB2).

Gene names and symbols associated with CACNA1F

  • calcium channel, voltage-dependent, L type, alpha 1F subunit (CACNA1F)
  • novel protein similar to vertebrate voltage-dependent calcium channel P/Q type alpha 1 subunit (CACNA1) (LOC559964)
  • calcium channel, voltage-dependent, L type, alpha 1F subunit (cacna1f)
  • calcium channel, voltage-dependent, alpha 1F subunit (Cacna1f)
  • calcium channel, voltage-dependent, L type, alpha 1F subunit (Cacna1f)
  • A930034B14 protein
  • AIED protein
  • CACNA1F protein
  • Cav1.4 protein
  • Cav1.4alpha1 protein
  • COD3 protein
  • COD4 protein
  • CORDX protein
  • CORDX3 protein
  • CSNB2 protein
  • CSNB2A protein
  • CSNBX2 protein
  • JM8 protein
  • JMC8 protein
  • nerg1 protein
  • nob2 protein
  • OA2 protein
  • Sfc17 protein

Protein level used designations for CACNA1F

calcium channel, voltage-dependent, L type, alpha 1F subunit , voltage-dependent L-type calcium channel subunit alpha-1F-like , L-type dihydropyridine-sensitive calcium channel alpha-1f subunit , voltage-dependent L-type calcium channel subunit alpha-1F , voltage-gated calcium channel subunit alpha Cav1.4 , calcium channel, voltage-dependent, alpha 1F subunit

GENE ID SPECIES
465629 Pan troglodytes
480915 Canis lupus familiaris
559964 Danio rerio
715787 Macaca mulatta
793708 Danio rerio
100386041 Callithrix jacchus
100565753 Anolis carolinensis
54652 Mus musculus
778 Homo sapiens
114493 Rattus norvegicus
100513061 Sus scrofa
509779 Bos taurus
Selected quality suppliers for Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit Proteins (CACNA1F)
Did you look for something else?