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anti-Calcium Channel, Voltage-Dependent, L Type, alpha 1S Subunit (CACNA1S) Antibodies

CACNA1S encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Additionally we are shipping CACNA1S Kits (5) and CACNA1S Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CACNA1S 779 Q13698
CACNA1S 12292  
CACNA1S 682930  
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Top anti-CACNA1S Antibodies at antibodies-online.com

Showing 10 out of 31 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF (p), IHC (p) Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000;  TMB staining;  Read the data in MicroplateReader by 450 Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti CACNA1S Polyclonal Antibody, Unconjugated (ABIN1387901) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded Cal27 xenograft , using CACNA1S, antibody at 1:100 dilution. WB Image Sample (30 ug of whole cell lysate) A: 293T 5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged CACNA1S is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Biotin IHC (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Cy5 IF (p)   100 μL Log in to see 14 to 21 Days
$379.50
Details

CACNA1S Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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More Antibodies against CACNA1S Interaction Partners

Human Calcium Channel, Voltage-Dependent, L Type, alpha 1S Subunit (CACNA1S) interaction partners

  1. CACNA1S and SCN4A (show SCN4A Antibodies) mutations are relatively rare in patients with hypokalemic periodic paralysis

  2. The authors found one and three rare variants of unknown significance in CACNA1S in the Malignant Hyperthermia and Exertional Heat cohorts

  3. Defects in the genes coding for the skeletal muscle ryanodine receptor (show RYR1 Antibodies) and alpha 1 subunit of the dihydropyridine receptor (CACNA1S) have been identified as causative for malignant hyperthermia.

  4. Aberrant splicing of Cav (show CA5A Antibodies) 1.1 may alter intracellular Ca(2 (show CA2 Antibodies)+) signalling in myotonic dystrophy 1 and 2 myotubes. The differing dysregulation of intracellular Ca(2 (show CA2 Antibodies)+) handling in DM1 (show DMPK Antibodies) and DM2 (show CNBP Antibodies) may explain their distinct sarcolemmal hyperexcitabilities.

  5. Exome sequencing revealed one rare cacna1s nonsynonymous variant in a family with malignant hyperthermia

  6. Data indicate that the presence of either one of these JP-45 (show JSRP1 Antibodies) variants decreased the sensitivity of the dihydropyridine receptor DHPR (show QDPR Antibodies) to activation.

  7. Affected members of a 5-generation Chinese family with hypokalemic periodic paralysis patients had a novel His916Gln mutation in all male HypoPP patients of the family. Penetrance of the mutation was complete in male carriers, but not female carriers.

  8. Misregulated splicing and altered gating of Ca(V)1.1 calcium channel is associated with muscle weakness in myotonic dystrophy.

  9. A novel mutation in the CACNA1S gene--p.Arg900Gly--is found in a patient with hypokalemic periodic paralysis; this mutation is subsequently found to affect some of the patient's other family members.

  10. All familial periodic paralysis patients studied have mutations in either CACNA1S or SCN4A (show SCN4A Antibodies), but only 4 sporadic periodic paralysis patients have de novo mutations in CACNA1S (R1239H) and SCN4A (show SCN4A Antibodies) (R669x2, R1135H).

Mouse (Murine) Calcium Channel, Voltage-Dependent, L Type, alpha 1S Subunit (CACNA1S) interaction partners

  1. Events occurring locally in the skeletal muscle of SOD1 mutant mice contribute to the impairment of CaV1.1 function in ALS muscle independently of innervation status.

  2. Knockdown of Cav1.1 channels in T cells abrogated calcium entry after TCR stimulation, suggesting that Cav1.1 channels are controlled by T cell receptor signaling

  3. Treatment of MSC (show MSC Antibodies) with BMP4 (show BMP4 Antibodies) caused a significant increase in expression of Cav1.2 (show CACNA1C Antibodies), a delay in expression of Cav1.1, and a reduction in the duration of calcium transients when extracellular calcium was removed

  4. This study delineates a previously uncharacterized CaV1.1-mediated pathway that regulates energy utilization in skeletal muscle.

  5. Raptor (show RPTOR Antibodies) ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex.

  6. amino-termini of Rad (show RRAD Antibodies) and Rem (show REM1 Antibodies) as the structural elements dictating the specific modes of inhibition of CaV1.1

  7. the localization and stability of Cacna1s depend on the expression of mGluR6 (show GRM6 Antibodies) and its cascade components, and they suggest that Cacna1s is part of the mGluR6 (show GRM6 Antibodies) complex.

  8. This work demonstrates the critical role of the chloride gradient in modulating the susceptibility to ictal weakness and establishes bumetanide as a potential therapy for hypokalaemic periodic paralysis arising from either NaV1.4 (show SCN4A Antibodies) or CaV1.1 mutations.

  9. Data propose a new role for Cav1.1 in the activation of signaling pathways allowing muscle fibers to decipher the frequency of electrical stimulation and to activate specific transcriptional programs that define their phenotype.

  10. Ca(2 (show CA2 Antibodies)+) transients evoked by tetanic stimulation are the result of massive Ca(2 (show CA2 Antibodies)+) influx due to enhanced Ca(v)1.1 channel activity, which restores muscle strength in JP45 (show JSRP1 Antibodies)/CASQ1 (show CASQ1 Antibodies) double knockout mice.

Pig (Porcine) Calcium Channel, Voltage-Dependent, L Type, alpha 1S Subunit (CACNA1S) interaction partners

  1. Results describe the cloning, sequencing and identification of single nucleotide polymorphisms of partial sequence on the porcine CACNA1S gene.

CACNA1S Antigen Profile

Protein Summary

This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility.

Gene names and symbols associated with CACNA1S

  • calcium channel, voltage-dependent, L type, alpha 1S subunit (CACNA1S) antibody
  • calcium channel, voltage-dependent, L type, alpha 1S subunit (cacna1s) antibody
  • calcium channel, voltage-dependent, L type, alpha 1S subunit (Cacna1s) antibody
  • AW493108 antibody
  • ca(v)1.1 antibody
  • CACNA1S antibody
  • CACNL1A3 antibody
  • caV1.1 antibody
  • Cchl1a3 antibody
  • fmd antibody
  • HOKPP antibody
  • HOKPP1 antibody
  • hypoPP antibody
  • mdg antibody
  • MHS5 antibody
  • sj antibody
  • TTPP1 antibody

Protein level used designations for CACNA1S

calcium channel, voltage-dependent, L type, alpha 1S subunit , voltage-dependent L type calcium channel alpha 1S subunit , voltage-dependent L-type calcium channel subunit alpha-1S , transverse tubule dihydropyridine receptor alpha 1 subunit , calcium channel, L type, alpha 1 polypeptide, isoform 3 (skeletal muscle, hypokalemic periodic paralysis) , dihydropyridine receptor , dihydropyridine-sensitive L-type calcium channel alpha-1 subunit , voltage-gated calcium channel subunit alpha Cav1.1 , calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle , DHPR alpha1s , dihydropyridine receptor alpha 1S , muscle dysgenesis , ROB1 , L-type calcium channel, alpha 1 subunit , voltage-gated calcium channel alpha 1S subunit

GENE ID SPECIES
469635 Pan troglodytes
490244 Canis lupus familiaris
654399 Felis catus
100034092 Equus caballus
100381134 Xenopus laevis
100734741 Cavia porcellus
779 Homo sapiens
100009585 Oryctolagus cuniculus
12292 Mus musculus
682930 Rattus norvegicus
395985 Gallus gallus
100286866 Sus scrofa
100337204 Bos taurus
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