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anti-Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) Antibodies

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Additionally we are shipping CACNA1A Kits (7) and CACNA1A Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CACNA1A 25398 P54282
CACNA1A 773 O00555
CACNA1A 12286 P97445
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Top anti-CACNA1A Antibodies at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Rat Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of rat brain membranes: 1. Anti-CaV2.1 antibody, (1:200). 2. Anti-CaV2.1 antibody, preincubated with the control peptide antigen. Human red blood cells. Expression of Cav2.1 in mouse cerebellum Immunohistochemical staining of mouse cerebellum with Anti-Cav2.1 antibody, (1:100). A. Cav2.1 channel (red) appears in Purkinje cells (horizontal arrows) and is distributed diffusely in the molecular layer (Mol) including in astrocytic fibers (vertical arrows). B. Staining of astrocytic fibers with glial fibrillary acidic protein in the section demonstrates the location of astrocytic fibers in the molecular layer. C. Merged image of panels A and B. 25 μL Log in to see 10 to 11 Days
$535.71
Details
Rat Rabbit Un-conjugated WB Observed bind size: 282KD 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated WB   100 μg Log in to see 8 to 10 Days
$463.83
Details
Rat Rabbit Un-conjugated IHC, WB 10 blots Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Rat Rabbit Un-conjugated IP, IHC, WB   50 μL Log in to see 11 to 16 Days
$608.14
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

CACNA1A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-CACNA1A Antibodies

  1. Human Polyclonal CACNA1A Primary Antibody for IHC, WB - ABIN350134 : Barry, Viglione, Kim, Froehner: Expression and antibody inhibition of P-type calcium channels in human small-cell lung carcinoma cells. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1995 (PubMed)
    Show all 5 references for ABIN350134

  2. Human Polyclonal CACNA1A Primary Antibody for IHC, WB - ABIN1742172 : Scheuber, Miles, Poncer: Presynaptic Cav2.1 and Cav2.2 differentially influence release dynamics at hippocampal excitatory synapses. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 (PubMed)
    Show all 3 references for ABIN1742172

  3. Rat (Rattus) Polyclonal CACNA1A Primary Antibody for WB - ABIN265030 : Starr, Prystay, Snutch: Primary structure of a calcium channel that is highly expressed in the rat cerebellum. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)

More Antibodies against CACNA1A Interaction Partners

Zebrafish Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) interaction partners

  1. The efficient activation of CaV2.1 channels during action potentials may contribute to the highly reliable transmission at zebrafish neuromuscular junctions.

Human Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) interaction partners

  1. South American cohort did not confirm the effect of the four candidate loci as modifier of onset age: mithocondrial A10398G polymorphism and CAGn at RAI1 (show DOM3Z Antibodies), CACNA1A, ATXN3 (show ATXN3 Antibodies), and ATXN7 (show ATXN7 Antibodies) genes

  2. Cav2.1 dysfunction in episodic ataxia (show USP14 Antibodies) type 2 has unexpected effects on axon excitability.

  3. CACNA1A might play a role in the etiology of autism as demonstrated in the Chinese Han population

  4. Expression of DnaJ-1 potently suppresses alpha1ACT-dependent degeneration , concomitant with decreased aggregation of the pathogenic protein. Mutating the nuclear importer karyopherin a3 (show KPNA4 Antibodies) also leads to reduced toxicity from pathogenic CACNA1A

  5. This report illustrates the phenotypic heterogeneity of CACNA1A loss-of-function mutations and stresses the cognitive and epileptic manifestations caused by the loss of CaV2.1 channels function

  6. Study revealed no association between the 15 tagSNPs of CACNA1A, 1C, and 1H and antiepileptic drug efficacy in the Chinese Han epileptic population; the TAGAA haplotype of CACNA1A may be a risk factor for drug resistance

  7. the consensus motifs of S-nitrosylation were much more abundant in Cav2.2 (show CACNA1B Antibodies) than in Cav1.2 (show CACNA1C Antibodies) and Cav2.1.

  8. A novel nonsense mutation of the CACNA1A gene was identified in all affected family members and is most likely the disease causing molecular defect

  9. The roles of the calcium-sensing receptor (CaSR (show CASR Antibodies)) and L-type voltage-dependent calcium channel (show CACNA1I Antibodies) (L-VDCC) in the proliferation and osteogenic differentiation of a calcium-exposed periodontal ligament stem/progenitor cells, were investigated .

  10. The results of this study suggest that the polyQ carrying the CT fragment of the P/Q-type channel is sufficient to cause SCA6 pathogenesis in mice.

Mouse (Murine) Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) interaction partners

  1. Findings demonstrate that the mutant Cav2.1 channel exerts a protective effect against cryogenic brain injury in rolling Nagoya mice

  2. results indicate that regulation of CaV2.1 channels by Ca(2 (show CA2 Antibodies)+) sensor proteins is essential for normal synaptic plasticity at the neuromuscular junction and for muscle strength, endurance, and motor coordination in mice in vivo

  3. regulation of CaV2.1 channels by calcium sensor proteins is required for normal short-term plasticity

  4. Thus, GHSR1a differentially inhibits CaV2 (show CAV2 Antibodies) channels by Gi/o or Gq protein pathways depending on its mode of activation.

  5. Genetic ablation of Cacna1a in layer VI neurons produced Absence Epilepsy.

  6. CACNA1A regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis.

  7. CaV2.1 Ca2 (show CA2 Antibodies)+ channel mutation leads to developmental abnormalities in Cl- transporter expression and GABAA (show GABRg1 Antibodies) receptor compositions in hippocampal neurons.

  8. Study of interstrain comparisons providing some insight into the role that specific Purkinje cell firing rate alterations play in the Cacna1a mutant phenotype

  9. Cacna1a mutations elevate neuronal [Ca(2 (show CA2 Antibodies)+)]i and alter synaptic morphology as a mechanism for enhanced cortical spreading depression susceptibility in a mouse model of familial hemiplegic migraine type 1.

  10. cav2.1 calcium channels have roles in regulating inhibitory and excitatory synaptic transmission in the lateral superior olive of mice

Cow (Bovine) Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) interaction partners

  1. new information on the hypothalamic expression of alpha1A and alpha1D subunits during development in a mammal with a long gestation period and a large and convoluted brain.

  2. cloned the full-length alpha1A subunit

Rabbit Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) interaction partners

  1. Gem (show GEM Antibodies) contains two candidate inhibitory sites, each capable of producing full inhibition of P/Q-type Ca(2 (show CA2 Antibodies)+) channels.

  2. describe a CACNA1A mutation (A454T) that disturbs the functional interaction between SNAREs and the poreforming alpha1A subunit, resulting in mutant P/Q channels that are less efficiently coupled to secretion.

CACNA1A Antigen Profile

Protein Summary

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.

Gene names and symbols associated with CACNA1A

  • calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (cacna1a) antibody
  • calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a (cacna1aa) antibody
  • calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A) antibody
  • calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (Cacna1a) antibody
  • P/Q-type voltage-gated calcium channel alpha1A subunit ChCaChA1A (LOC395892) antibody
  • alpha1A antibody
  • APCA antibody
  • BccA1 antibody
  • BI antibody
  • ca(v)2.1 antibody
  • Caca1a antibody
  • CACH4 antibody
  • CACN3 antibody
  • cacna-a antibody
  • cacna1a antibody
  • Cacnl1a4 antibody
  • CAV2.1 antibody
  • Ccha1a antibody
  • EA2 antibody
  • FHM antibody
  • HPCA antibody
  • la antibody
  • leaner antibody
  • MHP antibody
  • MHP1 antibody
  • nmf352 antibody
  • rbA-1 antibody
  • rkr antibody
  • rocker antibody
  • SCA6 antibody
  • si:ch211-237k17.1 antibody
  • tg antibody
  • tottering antibody

Protein level used designations for CACNA1A

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit , voltage-dependent calcium ion channel alpha subunit , ZfCav2.1 , BI , RBA-I , brain calcium channel 1 , brain calcium channel I , brain class A , calcium channel alpha 1A , calcium channel, L type, alpha-1 polypeptide , calcium channel, voltage-dependent, alpha 1A subunit , voltage-dependent P/Q-type calcium channel subunit alpha-1A , voltage-gated calcium channel subunit alpha Cav2.1 , P/Q-type calcium channel alpha1A subunit , calcium channel, P/Q type, alpha 1A , calcium channel, alpha 1A subunit , voltage-gated calcium channel alpha 1A subunit , calcium channel BI-1 , calcium channel BI-2

GENE ID SPECIES
373828 Xenopus laevis
562059 Danio rerio
100021108 Monodelphis domestica
25398 Rattus norvegicus
773 Homo sapiens
12286 Mus musculus
282648 Bos taurus
100009265 Oryctolagus cuniculus
395892 Gallus gallus
Selected quality suppliers for anti-CACNA1A (CACNA1A) Antibodies
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