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Calcium Channel, Voltage-Dependent, R Type, alpha 1E Subunit Proteins (CACNA1E)

Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. Additionally we are shipping CACNA1E Antibodies (28) and CACNA1E Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CACNA1E 777 Q15878
CACNA1E 12290  
Rat CACNA1E CACNA1E 54234  
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Top CACNA1E Proteins at antibodies-online.com

Showing 3 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CACNA1E Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Calcium Channel, Voltage-Dependent, R Type, alpha 1E Subunit (CACNA1E) Interaction Partners

Cow (Bovine) Calcium Channel, Voltage-Dependent, R Type, alpha 1E Subunit (CACNA1E) interaction partners

  1. Ca(v)2.3 Ca2 (show CA2 Proteins)+ channel interacts with the G1-subunit of V-ATPase (show ATP6V1H Proteins).

Zebrafish Calcium Channel, Voltage-Dependent, R Type, alpha 1E Subunit (CACNA1E) interaction partners

Human Calcium Channel, Voltage-Dependent, R Type, alpha 1E Subunit (CACNA1E) interaction partners

  1. Data suggest that, in vascular smooth muscle cells, increase in cytosolic endothelin-1 (EDN1 (show EDN1 Proteins)) induces sustained increase in nuclear Ca2 (show CA2 Proteins)+ via stimulation of R-type calcium channel (CACNA1E) present at the nuclear membrane.

  2. CACNA1E gene single nucleotide polymorphisms may be involved in fentanyl sensitivity.

  3. The C-terminus of human Ca(v)2.3 voltage-gated calcium channel interacts with alternatively spliced calmodulin-2 expressed in two human cell lines

  4. quartet of leucine residues in the guanylate kinase (show GUK1 Proteins) domain of CaVbeta determines the plasma membrane density of the CaV2.3 channel.

  5. CACNA1E variants affect beta cell function in patients with newly diagnosed type 2 diabetes.

  6. the II-III loop of the Ca(v)2.3 calcium channel binds APLP1 (show APLP1 Proteins) and that this binding promotes internalization of the channel

  7. Ca(v)2.3 Ca2 (show CA2 Proteins)+ channel interacts with the G1-subunit of V-ATPase (show ATP6V1H Proteins).

  8. Lack of high-voltage activated Cav2.3 channels results in a marked decrease in the sensitivity of transgenic animals to gamma-butyrolactone-induced absence epilepsy.

  9. Swapping the I-II intracellular linker between L-type CaV1.2 (show CACNA1C Proteins) and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributes.

  10. Review discusses the roles of Cav2.3-containing E-type Ca2 (show CA2 Proteins)+ channels which exhibit several subunit-specific features, trigger exocytosis and are also involved in long-term potentiation.

Mouse (Murine) Calcium Channel, Voltage-Dependent, R Type, alpha 1E Subunit (CACNA1E) interaction partners

  1. Data show that apamin boosts evoked excitatory postsynaptic potentials (EPSPs) in CaV2.3 R-Type Ca2 (show CA2 Proteins)+ Channel knockout (CaV2.3-/-) mice.

  2. under conditions of Zn2+ deficiency, ablation or dysfunction of Cav2.3 channels may lead to severe disturbances in glucose homeostasis.

  3. Cav2.1 (show CACNA1A Proteins)-2.3 have unique contributions to the dynamics at the Schaffer collateral synapse that are engaged by the complex patterns of afferent activity seen in vivo

  4. Low-voltage activated CaV2.3 R-type Ca(2 (show CA2 Proteins)+) channels in the thalamocortical loop and extra-thalamocortical circuitries substantially regulate rodent sleep architecture and represent a novel potential target for pharmacological treatment of sleep disorders

  5. Cacna1e expression (and Cacna1h (show CACNA1H Proteins)) is essential for paraventricular hypothalamic neuronal activity and preventing hyperphagia.

  6. Cav2.3 does not only contribute to the cardiac autonomous nervous system but also to intrinsic rhythm propagation.

  7. Cav2.3 voltage-gated divalent calcium channels (VGCC) are an important factor in septohippocampal synchronization associated with theta; oscillation.

  8. stimulation with exogenous PACAP (show ADCYAP1 Proteins) and native neuronal stress stimulation both lead to a PKC-mediated phosphodependent recruitment of a T-type Ca(v)3.2 Ca(2 (show CA2 Proteins)+) influx, which in turn evokes catecholamine release during the acute sympathetic stress response

  9. Both high-affinity Ni(2 (show VMP1 Proteins)+)-sensitive Ca(2 (show CA2 Proteins)+) channels contribute to transretinal signalling.

  10. Ca(v)2.3 (alpha1E) Ca2 (show CA2 Proteins)+ channel participates in the control of sperm function.

Rabbit Calcium Channel, Voltage-Dependent, R Type, alpha 1E Subunit (CACNA1E) interaction partners

  1. Inhibition of CaV2.3 channels by NK1 (show B3GAT1 Proteins) receptors is sensitive to membrane cholesterol but insensitive to caveolin-1 (show CAV1 Proteins).

CACNA1E Protein Profile

Protein Summary

Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with CACNA1E

  • calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E)
  • novel protein similar to vertebrate calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) (LOC564274)
  • calcium channel, voltage-dependent, R type, alpha 1E subunit (Cacna1e)
  • A430040I15 protein
  • alpha1E protein
  • BII protein
  • Cach6 protein
  • CACHA1E protein
  • CACNA1E protein
  • Cacnl1a6 protein
  • Cav2.3 protein
  • Cchra1 protein

Protein level used designations for CACNA1E

voltage-dependent R-type calcium channel subunit alpha-1E , voltage-gated calcium channel alpha 1E subunit , calcium channel, voltage-dependent, R type, alpha 1E subunit , brain calcium channel II , calcium channel, L type, alpha-1 polypeptide , calcium channel, R type, alpha-1 polypeptide , calcium channel, voltage-dependent, alpha 1E subunit , voltage-dependent calcium channel alpha 1E subunit , voltage-gated calcium channel alpha subunit Cav2.3 , voltage-gated calcium channel subunit alpha Cav2.3 , calcium channel, voltage-dependent, L type, alpha 1E subunit , BII , RBE-II , RBE2 , voltage gated calcium channel alpha1E subunit , voltage-dependent calcium channel alpha1-E subunit , brain calcium channel BII-1 , brain calcium channel BII-2

GENE ID SPECIES
353113 Bos taurus
424412 Gallus gallus
490305 Canis lupus familiaris
564274 Danio rerio
718092 Macaca mulatta
100017762 Monodelphis domestica
777 Homo sapiens
12290 Mus musculus
54234 Rattus norvegicus
100009403 Oryctolagus cuniculus
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