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Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 Proteins (CACNA2D1)

CACNA2D1 encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Additionally we are shipping CACNA2D1 Antibodies (66) and CACNA2D1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CACNA2D1 781 P54289
CACNA2D1 12293 O08532
Rat CACNA2D1 CACNA2D1 25399  
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Top CACNA2D1 Proteins at antibodies-online.com

Showing 4 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details

CACNA2D1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
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More Proteins for Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) Interaction Partners

Human Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) interaction partners

  1. detected a joint effect of SNP and G x E interaction in BMP2 (show BMP2 Proteins) and CACNA2D1 for depressive state.

  2. All three patients present with epilepsy and intellectual disability pinpointing the CACNA2D1 gene as an interesting candidate gene for these clinical features.

  3. Compound mutation of CACNA2D1 and RANGRF (show RANGRF Proteins) genes were found. To the best of our knowledge, this is the first comprehensive description of the concurrence of these two mutations and histiocytoid cardiomyopathy.

  4. High prevalence of CACNA2D1, SCN5A (show SCN5A Proteins), and CACNB2 (show CACNB2 Proteins) genetic variants in the Danish population previously associated with Brugada syndrome has been found in new exome data.

  5. Functional expression of CACNA2D1 is inhibited by prion protein (show PRNP Proteins) expression with competition at glycosylphosphatidylinositol.

  6. this study reports the identification and characterization of the human alpha2delta-1 subunit gene promoter region and its regulation by specific transcription factor 1.

  7. In neocortical slices from transgenic mice having a point mutation (i.e., R217A) of the alpha2delta-1 subunit of voltage-sensitive calcium channels, pregabalin does not affect potassium-evoked glutamate (show GRIN1 Proteins) release, yet inhibits this release in wild-type mice.

  8. Results show that mutation of CACNA2D1 gene causes a new varant of SCTS (show ANO6 Proteins).

  9. CACNA2D1 is a novel Brugada Syndrome susceptibility gene.

  10. CACNA2D1 has structural domains which contribute to the regulation of N-type calcium channel inactivation

Rabbit Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) interaction partners

  1. these findings provide evidence for a new role of Homer1 (show HOMER1 Proteins) supporting the regulation of Cav1.2 (show CACNA1C Proteins) channels by STIM1 (show STIM1 Proteins).

Pig (Porcine) Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) interaction partners

Cow (Bovine) Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) interaction partners

  1. The objective of the present study was to identify polymorphisms of the CACNA2D1 gene, and to analyze associations between these polymorphisms and mastitis in several cattle breeds.

  2. CACNA2D1 gene is one of the potential candidate genes influencing carcass and meat quality traits.

Mouse (Murine) Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) interaction partners

  1. CaV2.2 (show CACNA1B Proteins) and alpha2delta-1 are intimately associated at the plasma membrane

  2. These findings suggest that the alpha(2)delta(4) subunit participates in the modulation of L-type Ca(2 (show CA2 Proteins)+) current regulating neurotransmitter release from photoreceptor terminals

  3. Expression of Cacna2d1 is enhanced in the amygdala in a model of innate anxiety.

  4. This study demonistrated that Cacna2d1 gene expression in mouse dorsal raphe nucleus

  5. association of calcium channel alpha2/delta subunit 1 and ATP5b (show ATP5B Proteins) occurs in intracellular membranes and at the plasma membrane of developing muscle cells, where they form a signaling complex capable of accelerating the rate of decline of calcium transients

  6. mechanism of Cavalpha2delta1-mediated spinal sensitization in which elevated Cavalpha2delta1 causes increased pre-synaptic glutamate (show GRIN1 Proteins) release that leads to reduced excitation thresholds of post-synaptic dorsal horn neurons to innocuous stimuli.

CACNA2D1 Protein Profile

Protein Summary

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Gene names and symbols associated with CACNA2D1

  • calcium channel, voltage-dependent, alpha 2/delta subunit 1 (CACNA2D1)
  • calcium channel, voltage-dependent, alpha 2/delta subunit 1 (cacna2d1)
  • calcium channel, voltage-dependent, alpha 2/delta subunit 1 (Cacna2d1)
  • calcium channel, voltage-dependent, alpha2/delta subunit 1 (Cacna2d1)
  • Ca(v)alpha2delta1 protein
  • Cacna2 protein
  • CACNA2D1 protein
  • CACNL2A protein
  • Cchl2a protein
  • CCHLA2 protein
  • DHSCCA protein
  • DKFZp469K2211 protein

Protein level used designations for CACNA2D1

calcium channel, voltage-dependent, alpha 2/delta subunit 1 , voltage-dependent calcium channel subunit alpha-2/delta-1-like , calcium channel, L type, alpha 2 polypeptide , dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit , voltage-dependent calcium channel subunit alpha-2/delta-1 , voltage-gated calcium channel subunit alpha-2/delta-1 , dihydropryridine-sensitive calcium channel alpha-2 subunit , dihydropyridine-sensitive calcium channel alpha 2 , Calcium channel subunit alpha 2 delta (dihydropyridine - sensitive L-type)

GENE ID SPECIES
463504 Pan troglodytes
708215 Macaca mulatta
100012746 Monodelphis domestica
100036724 Xenopus (Silurana) tropicalis
100171724 Pongo abelii
100463812 Ailuropoda melanoleuca
100566428 Anolis carolinensis
100595072 Nomascus leucogenys
781 Homo sapiens
100009105 Oryctolagus cuniculus
100728887 Cavia porcellus
768444 Gallus gallus
610342 Canis lupus familiaris
397377 Sus scrofa
282608 Bos taurus
12293 Mus musculus
25399 Rattus norvegicus
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