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CACNA2D2 encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Additionally we are shipping CACNA2D2 Antibodies (37) and many more products for this protein.
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The investigation of single nucleotide polymorphisms in three genes that have a functional impact on the opioid response: OPRM1 (show OPRM1 Proteins), ABCB1 (show ABCB1 Proteins) and the calcium channel complex subunit CACNA2D2, is reported.
CACNA2D2 deletion/methylation is associated with cervical disease progression.
In mice, targeted disruption of Cacna2d2 led to growth retardation, reduced life span, ataxia (show USP14 Proteins), enhanced susceptibility to seizures, and cardiac abnormalities. Cacna2d2 may be involved in hereditary cerebellar ataxias and epileptic disorders in humans.
Although transgenic du(2J)/+ mice have a marked reduction in alpha2delta-2 protein, they show no fall in Purkinje somatic calcium currents or increase in cerebellar tyrosine hydroxylase (show TH Proteins) gene expression.
all of the alpha(2)delta subunits studied, alpha(2)delta-1, alpha(2)delta-2, and alpha(2)delta-3 (show CACNA2D3 Proteins), show all of the properties expected of glycosylphosphatidylinositol-anchored proteins, both when heterologously expressed and in native tissues.
We show that both mRNA and protein corresponding to this predicted transcript are expressed in du/du cerebellum and present in Purkinje cells
Cacna2d2 has a role in epilepsy and ataxia (show USP14 Proteins)
Both alpha2delta-2 and CaV2.1 (show CACNA1A Proteins) are normally associated with cholesterol-rich microdomains, and this influences their functionality.
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
alpha 2 delta calcium channel subunit
, gene 26
, voltage-dependent calcium channel subunit alpha-2/delta-2
, voltage-gated calcium channel subunit alpha-2/delta-2
, protein ducky
, calcium channel, voltage dependent, alpha2/delta subunit 2