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Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 2 Proteins (CACNA2D2)

CACNA2D2 encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Additionally we are shipping CACNA2D2 Antibodies (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CACNA2D2 9254 Q9NY47
CACNA2D2 56808 Q6PHS9
Rat CACNA2D2 CACNA2D2 300992 Q8CFG6
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Top CACNA2D2 Proteins at antibodies-online.com

Showing 6 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CACNA2D2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,

More Proteins for Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 2 (CACNA2D2) Interaction Partners

Human Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 2 (CACNA2D2) interaction partners

  1. The investigation of single nucleotide polymorphisms in three genes that have a functional impact on the opioid response: OPRM1 (show OPRM1 Proteins), ABCB1 (show ABCB1 Proteins) and the calcium channel complex subunit CACNA2D2, is reported.

  2. CACNA2D2 deletion/methylation is associated with cervical disease progression.

  3. In mice, targeted disruption of Cacna2d2 led to growth retardation, reduced life span, ataxia (show USP14 Proteins), enhanced susceptibility to seizures, and cardiac abnormalities. Cacna2d2 may be involved in hereditary cerebellar ataxias and epileptic disorders in humans.

  4. Although transgenic du(2J)/+ mice have a marked reduction in alpha2delta-2 protein, they show no fall in Purkinje somatic calcium currents or increase in cerebellar tyrosine hydroxylase (show TH Proteins) gene expression.

Mouse (Murine) Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 2 (CACNA2D2) interaction partners

  1. all of the alpha(2)delta subunits studied, alpha(2)delta-1, alpha(2)delta-2, and alpha(2)delta-3 (show CACNA2D3 Proteins), show all of the properties expected of glycosylphosphatidylinositol-anchored proteins, both when heterologously expressed and in native tissues.

  2. We show that both mRNA and protein corresponding to this predicted transcript are expressed in du/du cerebellum and present in Purkinje cells

  3. Cacna2d2 has a role in epilepsy and ataxia (show USP14 Proteins)

  4. In mice, targeted disruption of Cacna2d2 led to growth retardation, reduced life span, ataxia (show USP14 Proteins), enhanced susceptibility to seizures, and cardiac abnormalities. Cacna2d2 may be involved in hereditary cerebellar ataxias and epileptic disorders in humans.

  5. Both alpha2delta-2 and CaV2.1 (show CACNA1A Proteins) are normally associated with cholesterol-rich microdomains, and this influences their functionality.

CACNA2D2 Protein Profile

Protein Summary

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

Gene names and symbols associated with CACNA2D2

  • calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2)
  • calcium channel, voltage-dependent, alpha 2/delta subunit 2 (Cacna2d2)
  • a2d2 protein
  • Cacna2d protein
  • du protein
  • LUAC11.1 protein
  • mKIAA0558 protein
  • td protein
  • torpid protein

Protein level used designations for CACNA2D2

alpha 2 delta calcium channel subunit , gene 26 , voltage-dependent calcium channel subunit alpha-2/delta-2 , voltage-gated calcium channel subunit alpha-2/delta-2 , ducky , protein ducky , calcium channel, voltage dependent, alpha2/delta subunit 2

GENE ID SPECIES
9254 Homo sapiens
56808 Mus musculus
300992 Rattus norvegicus
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