Calcium Channel, Voltage-Dependent, beta 1 Subunit Proteins (CACNB1)

The protein encoded by CACNB1 belongs to the calcium channel beta subunit family. Additionally we are shipping CACNB1 Antibodies (117) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CACNB1 782 Q02641
CACNB1 12295 Q8R3Z5
CACNB1 50688 P54283
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Top CACNB1 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,719.83
Details

CACNB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) Interaction Partners

Zebrafish Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) interaction partners

  1. beta subunits, probably via the SH3-C-terminal polyproline interaction, adapt a discrete conformation required to modify the alpha1S conformation apt for voltage sensing in skeletal muscle.

  2. Disruption of functional dihydropyridine receptor (show CACNA1S Proteins) (DHPR (show QDPR Proteins))-ryanodine receptor (show RYR3 Proteins) (RyR1 (show RYR1 Proteins)) interactions caused by lack of the beta 1a subunit is responsible for paralysis of skeletal muscle in beta 1-null muscle cells.

  3. Relaxed mutant muscles are defective in excitation-contraction coupling. The mutant phenotype results from non-sense mutations in the zebrafish CACNB1 gene that encodes the DHPR (show QDPR Proteins) beta1 subunit.

  4. triad expression and facilitation of 1,4-dihydropyridine receptor (show CACNA1S Proteins) (DHPR (show QDPR Proteins)) charge movement are common features of all tested beta subunits

Human Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) interaction partners

  1. These results provide new insights into the role of muscle-specific (show EIF3K Proteins) proteins on the structural arrangement of alpha1S intracellular loops and point to a new conformational effect of the beta1a subunit in supporting skeletal muscle excitation-contraction coupling.

  2. CACNB1, encoding cardiac L-type calcium channel beta 1 subunit, is a potential target for microRNA-328 in transgenic mice.

Mouse (Murine) Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) interaction partners

  1. Structural and biophysical analyses of the skeletal dihydropyridine receptor (show CACNA1S Proteins) beta subunit (show POLG Proteins) beta1a reveal critical roles of domain interactions for stability.

  2. These results provide new insights into the role of muscle-specific (show EIF3K Proteins) proteins on the structural arrangement of alpha1S intracellular loops and point to a new conformational effect of the beta1a subunit in supporting skeletal muscle excitation-contraction coupling.

  3. The present study reveals that the C-terminal of the beta1a subunit changes conformation in the presence of RyR1 (show RYR1 Proteins) consistent with an interaction between the C-terminal of beta1a and RyR1 (show RYR1 Proteins) in resting myotubes.

  4. The motif Leu(496)-Leu(500)-Trp (show TYRP1 Proteins)(503) within the bet1a C-terminal tail plays a nonessential role in the bidirectional DHPR (show QDPR Proteins)/RyR1 (show RYR1 Proteins) signaling that supports skeletal-type excitation-contraction coupling.

  5. Cavbeta1a acts as a Cav (show CA5A Proteins)-independent regulator of gene expression in MPCs, and is required for their normal expansion during myogenic development.

  6. Data suggest that specific hydrophobic surface residues in calcium channel voltage-dependent beta1a subunit C-terminus bind to RyR1 (show RYR1 Proteins) and increase channel activity in lipid bilayers and thus may support skeletal muscle excitation-contraction coupling.

  7. The results of this study indicated that the skeletal muscle DHPR (show QDPR Proteins) retrogradely regulates the patterning and formation of the Neuromuscular junction.

  8. Mice with cardiac-specific sequestration of the beta-subunit (show POLG Proteins) of the L-type calcium channel

  9. calcium channel beta1a subunits are organized in triad junctions in skeletal muscle

  10. excitation-contraction coupling in skeletal muscle involves the interplay of at least two subunits of the DHPR (show QDPR Proteins), namely alpha1S and beta1a, interacting with possibly different domains of RyR1 (show RYR1 Proteins) [DHPR (show QDPR Proteins) beta1a]

CACNB1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.

Gene names and symbols associated with CACNB1

  • calcium channel, voltage-dependent, beta 1 subunit (CACNB1)
  • calcium channel, voltage-dependent, beta 1 subunit (cacnb1)
  • calcium channel, voltage-dependent, beta 1 subunit (Cacnb1)
  • dihydropyridine-sensitive calcium channel beta-subunit (LOC100009109)
  • CAB1 protein
  • CACNB1 protein
  • CACNLB1 protein
  • Cchb1 protein
  • Cchlb1 protein
  • zgc:91982 protein

Protein level used designations for CACNB1

calcium channel, voltage-dependent, beta 1 subunit , voltage-dependent L-type calcium channel subunit beta-1-like , calcium channel beta1a subunit , dihydropyridine receptor b1 , dihydropyridine receptor beta 1a subunit , dihydropyridine receptor beta 1c subunit , red , relaxed , voltage-dependent L-type calcium channel subunit beta-1 , calcium channel voltage-dependent subunit beta 1 , calcium channel, L type, beta 1 polypeptide , dihydropyridine-sensitive L-type, calcium channel beta-1 subunit , CAB1 , voltage dependent calcium channel, beta1 subunit, variant5 , voltage-dependent calcium channel beta1 subunit , brain calcium channel beta 1 subunit , calcium channel beta 1 subunit

GENE ID SPECIES
454624 Pan troglodytes
695864 Macaca mulatta
100158521 Xenopus (Silurana) tropicalis
100456553 Pongo abelii
436925 Danio rerio
782 Homo sapiens
491030 Canis lupus familiaris
327703 Bos taurus
12295 Mus musculus
50688 Rattus norvegicus
100127255 Xenopus laevis
100514316 Sus scrofa
100009109 Oryctolagus cuniculus
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