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The protein encoded by CACNG8 is a type I transmembrane AMPA receptor regulatory protein (TARP). Additionally we are shipping and many more products for this protein.
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Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 (show KCNN3 Antibodies) and KCNJ2 (show KCNJ2 Antibodies) Genes and CACNG8-Linked Left Ventricular Dysfunction
these findings demonstrate that TARPgamma-8 is a crucial mediator of CaMKII (show CAMK2G Antibodies)-dependent Long Term Potentiation and therefore a molecular target that controls synaptic plasticity and associated cognitive functions.
TARP gamma-8 is the only TARP (show TINAGL1 Antibodies) expressed at nonperforated type of pyramidal cell synapses, playing an essential role in low-density or basal AMPAR expression
This study demonstrated that genetic inactivation of this specific population of AMPA (show GRIA3 Antibodies) receptors results in modest changes in behavior characterized by a mild hyperactivity.
coexpression of both auxiliary subunits,CKAMP44 (show Shisa9 Antibodies) and TARP gamma-8 is necessary for the efficient targeting of AMPARs to the cell surface of dentate gyrus granule cells
The results of thia study suggested that there are distinct TARP (show TINAGL1 Antibodies)-dependent mechanisms for synaptic transmission and long term potential.
Tarp gamma-8 (and CNIH-2 (show CNIH2 Antibodies)) functionally interact with common AMPA (show GRIA3 Antibodies) receptor complexes in hippocampus; however, TARP gamma-8-containing hippocampal neurons do not display resensitization.
Previously uncharacterized roles for the TARP (show TINAGL1 Antibodies) intracellular N terminus, loop, and C terminus in modulating both the trafficking and gating of synaptic AMPARs, are reported.
Discusses evidence for non-AUG translation start codon for Cacng8.
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon.
calcium channel, voltage-dependent, gamma subunit 8
, voltage-dependent calcium channel gamma-8 subunit
, TARP gamma-8
, neuronal voltage-gated calcium channel gamma-8 subunit
, transmembrane AMPAR regulatory protein gamma-8
, TARP gamma 8