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CALHM1 encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. Additionally we are shipping CALHM1 Antibodies (37) and CALHM1 Proteins (4) and many more products for this protein.
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In the presence of antibody, P86L-CALHM1 shifts the balance between neurodegeneration and neuronal survival toward the stimulation of pro-cytotoxic pathways, thus potentially contributing to its deleterious effects in Alzheimer's disease.
CALHM1 polymorphism may be potential biomarker in patients with Alzheimer disease. [meta-analysis]
The rare R154H variant interferes with CALHM1 control of cytosolic Ca2 (show CA2 ELISA Kits)+ and Abeta (show APP ELISA Kits) accumulation.
CALHM1 p.P86L variation may not be an AD susceptibility factor in the Han Chinese population.
This study showed that No association between polymorphisms in the calcium homeostasis modulator 1 gene and mesial temporal lobe epilepsy risk in a Chinese population
rare genetic variants in CALHM1 lead to Ca(2 (show CA2 ELISA Kits)+) dysregulation and may contribute to the risk of EOAD through a mechanism independent from the classical Ass (show ASS1 ELISA Kits) cascade.
The study identifies a previously uncharacterized mechanism of control of Ca(2 (show CA2 ELISA Kits)+)-dependent ERK1/2 (show MAPK1/3 ELISA Kits) signaling in neurons, and further establishes CALHM1 as a critical ion channel for neuronal signaling and function.
Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins.
CALHM1 is a voltage-gated ATP-release channel required for sweet, bitter and umami taste perception
An association between the CALHM1 polymorphism and the risk for Alzheimer's disease, was not detected.
Abeta (show APP ELISA Kits) level reduction by CALHM1 could be explained by an increase in extracellular Abeta (show APP ELISA Kits) degradation by insulin-degrading enzyme (show IDE ELISA Kits).
Multiple transduction pathways make complex, concentration-dependent contributions to salty taste perception. One of these pathways depends on CALHM1 to detect hypertonic NaCl in the mouth and signal the aversive taste of concentrated salt.
This study demonistrated that the Calhm1 knockot mice consumed only half as much sugar per day as did Wild type mice.
Calhm1 was of rare abundance in brain tissues
CALHM1 is an evolutionarily conserved ion channel family that detects membrane voltage and extracellular Ca(2 (show CA2 ELISA Kits)+) levels and plays a role in cortical neuronal excitability and Ca(2 (show CA2 ELISA Kits)+) homeostasis
This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.
calcium homeostasis modulator 1
, novel protein similar to vertebrate calcium homeostasis modulator protein family
, calcium homeostasis modulator protein 1
, family with sequence similarity 26, member C