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CIB1 encodes a member of the EF-hand domain-containing calcium-binding superfamily. Additionally we are shipping CIB1 Proteins (9) and CIB1 Kits (4) and many more products for this protein.
Showing 10 out of 121 products:
Human Polyclonal CIB1 Primary Antibody for WB - ABIN1881205
Jarman, Moretti, Zebol, Pitson: Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1. in The Journal of biological chemistry 2009
Show all 5 Pubmed References
Human Monoclonal CIB1 Primary Antibody for IHC, ELISA - ABIN969057
Gentry, Singer, Betts, Yang, Ferrara, Sondek, Parise: Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins. in The Journal of biological chemistry 2005
Show all 2 Pubmed References
Human Monoclonal CIB1 Primary Antibody for IHC, ELISA - ABIN965897
White, Yang, Monteiro, Foskett: CIB1, a ubiquitously expressed Ca2+-binding protein ligand of the InsP3 receptor Ca2+ release channel. in The Journal of biological chemistry 2006
Show all 2 Pubmed References
Results suggest that interaction of CIB1 with alphaIIb is one of the early events occurring during outside-in signaling. Furthermore, CIB1 recruits FAK to the alphaIIbbeta3 complex at the filopodia where FAK is activated, which in turn activates c-Src, resulting in propagation of outside-in signaling leading to platelet spreading.
we found that ectopic expression of oncogenic KRas and HRas (show HRAS Antibodies) in cells resulted in elevated CIB1 expression. We previously described the Ca(2 (show CA2 Antibodies)+)-myristoyl switch function of CIB1, and its ability to facilitate agonist-induced plasma membrane localisation of sphingosine kinase 1 (SK1 (show SPHK1 Antibodies)), a location where SK1 (show KCNN1 Antibodies) is known to elicit oncogenic signalling.
a large subset of TNBCs depend on CIB1 for cell survival and tumor growth, independent of CIB1 expression levels.
mRNA and protein expression levels of CIB1 were decreased in the oligoasthenozoospermia patients.CIB1 may be involved in the pathogenesis of oligoasthenozoospermia by the CDK1 (show CDK1 Antibodies) signaling pathway.
High serum CIB1 levels are associated with pancreatic cancer.s
KIP binding to TRF2 (show TERF2 Antibodies) enhances the telomere-binding activity of TRF2 (show TERF2 Antibodies), suggesting that KIP acts as a positive regulator of TRF2 (show TERF2 Antibodies) function.
these studies suggested that Kaposi's sarcoma-associated herpesvirus utilizes CIB1 as one of the key molecule(s) to coordinate and sustain the EphA2 (show EPHA2 Antibodies) mediated signaling involved in its entry
CIB1a is a novel mediator of PKD2 (show PKD2 Antibodies)-driven carcinogenesis.
we present data that show that CIB1 binds to seven additional alpha-integrin CT peptides, bringing the total number of alpha-integrins that can associate with CIB1 to eight.
Results indicate that CIB1 is uniquely positioned to regulate PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) signaling and that simultaneous disruption of these pathways synergistically induces a nuclear GAPDH (show GAPDH Antibodies)-dependent cell death.
results suggest that interaction of CIB1 with alphaIIb is one of the early events occurring during outside-in signaling. Furthermore, CIB1 recruits FAK to the alphaIIbbeta3 complex at the filopodia where FAK is activated, which in turn activates c-Src, resulting in propagation of outside-in signaling leading to platelet spreading.
CIB1 is involved in regulating endomitosis, perhaps through its interaction with Polo-like kinase 3 (show PLK3 Antibodies)
Data demonstrate that CIB1 is not required for AID to mediate antibody gene diversification processes. It remains possible that CIB1 has an alternative, a redundant or a subtle non-limiting regulatory role in AID biology.
CIB1 functions as a previously undescribed regulator of cardiac hypertrophy through its ability to regulate the association of calcineurin with the sarcolemma and its activation.
CIB1 is a key regulator of thrombosis, by affecting platelet spreading, but not platelet filopodia formation.
CIB co-immunoprecipitated with Snk and inhibited the kinase activity of Snk, suggesting that CIB is a negative regulator for Snk kinase activity.
MEFs derived from Cib1(-/-) mice exhibit a much slower growth rate compared to Cib1(+/+) MEFs, suggesting that CIB1 regulates the cell cycle, differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.
loss of CIB1 in endothelial cells decreases p21-activated kinase 1 (show PAK1 Antibodies) activation, downstream extracellular signal-regulated kinase 1/2 (show MAPK3 Antibodies) activation, and matrix metalloproteinase 2 (show MMP2 Antibodies) expression, all of which are known to contribute to angiogenesis.
This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants.
calcium and integrin-binding protein 1
, calcium and integrin binding protein 1
, Calcium and integrin-binding protein 1
, DNA-PK interaction protein
, DNA-PKcs-interacting protein
, DNA-dependent protein kinase interacting protein
, SNK-interacting protein 2-28
, calcium and integrin binding, protein kinase interacting protein
, kinase-interacting protein
, protein kinase, DNA activated, catalytic polypeptide interacting protein
, calcium- and integrin-binding protein