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The protein encoded by CASR is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. Additionally we are shipping Calcium-Sensing Receptor Kits (46) and Calcium-Sensing Receptor Proteins (13) and many more products for this protein.
Showing 10 out of 144 products:
Human Polyclonal CASR Primary Antibody for EIA, WB - ABIN492848
Chou, Pollak, Brandi, Toss, Arnqvist, Atkinson, Papapoulos, Marx, Brown, Seidman: Mutations in the human Ca(2+)-sensing-receptor gene that cause familial hypocalciuric hypercalcemia. in American journal of human genetics 1995
Show all 3 references for ABIN492848
Mouse (Murine) Polyclonal CASR Primary Antibody for WB - ABIN1881139
OSeaghdha, Yang, Glazer, Leak, Dehghan, Smith, Kao, Lohman, Hwang, Johnson, Hofman, Uitterlinden, Chen, Brown, Siscovick, Harris, Psaty, Coresh, Gudnason, Witteman, Liu, Kestenbaum, Fox, Köttgen: Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. in Human molecular genetics 2010
Show all 2 references for ABIN1881139
Human Polyclonal CASR Primary Antibody for ICC, FACS - ABIN1742166
Rácz, Kittel, Riccardi, Case, Elliott, Varga: Extracellular calcium sensing receptor in human pancreatic cells. in Gut 2002
Show all 2 references for ABIN1742166
CaSR activation may play a fundamental role in selecting specific differentiation checkpoints of neurogenesis and osteogenesis
The extracellular calcium-sensing receptor is expressed in the cumulus-oocyte complex in mammals and modulates oocyte meiotic maturation.
Calcium and the calcimimetic NPS (show NPS Antibodies) R-467 reduce CaSR mRNA expression and stimulate cell growth/proliferation in equine size-sieved umbilical cord matrix mesenchymal stem cell.
CaSR-induced constitutive macropinocytosis facilitates the sentinel function of macrophages, promoting the efficient delivery of ligands to cytosolic pattern-recognition receptors.
Downregulation of CaSR may contribute to the prevention or suppression of tumor outgrowth in gastric cancer.
The rs17251221 single nucleotide polymorphism of CaSR is a risk factor associated with breast cancer susceptibility, as well as a prognostic indicator.
A novel naturally occurring deletion mutation within the CASR that apparently arose de novo in the father of the Autosomal dominant hypocalcemia proband.
Aortic smooth muscle cells under static or strained conditions were exposed to CaSR agonists, R568, and CaSR silencing and over-expression. High Ca reduced CaSR expression. Cyclic strain or R568 prevented this. CaSR silencing enhanced calcification.
the identification of a novel heterozygous loss-of-function mutation of the CASR gene in three siblings with familial hypocalciuric hypercalcaemia
Results suggest that the G allele and the homozygous GG genotype of the CaSR rs17251221 polymorphism are protective against ovarian cancer and represent low risk for it.
CaSR activation elevates visceral preadipocyte proliferation.
these studies suggest that 14-3-3 (show YWHAQ Antibodies) binding at the carboxyl terminus provides an important buffering mechanism to increase the intracellular pool of CaSR available for signaling-evoked trafficking
Both vitamin D and calcium are needed for protection against malignant transformation of the colon and that their effect is modulated by the presence of a functional CaSR.
CaSR was localized in the basolateral membrane of basolateral membrane of type-B intercalated cell and was more expressed during alkali-loading
Demonstrate a role for CaSR in cardiovascular system and suggest physiologically relevant changes in extracellular Ca(2 (show CA2 Antibodies)+) concentrations could contribute to setting blood vessel tone levels and heart rate by directly acting on the cardiovascular CaSR.
fluoride might be able to affect calcium homeostasis by regulating PTH (show PTH Antibodies), PTHrP (show PTHLH Antibodies), and CaSR
the activation of CaSR in the collecting duct prevents the cyclic AMP (show TMPRSS5 Antibodies)-dependent increase in AQP2 (show AQP2 Antibodies)-phosphorylation at S256 and water permeability, counteracting the short-term vasopressin (show AVP Antibodies) response.
Deoxynivalenol induced cholecystokinin (show CCK Antibodies) and glucagon-like peptide 1 (show GCG Antibodies) release by enteroendocrine cells in mediated by casR/TRPA1 (show TRPA1 Antibodies) signaling.
Calcium-sensing receptor has a role in airway hyperresponsiveness and inflammation in allergic asthma
CaSR and OGR1 (show GPR68 Antibodies) reciprocally inhibit signaling through each other in central neurons, and that this is lost in their transformed counterparts. Acidification impairs CaSR
results demonstrate a critical tumor suppressive role of CaSR in the colon. Restoration of CaSR expression and function is linked to regulation of the balance between proliferation, differentiation, and apoptosis
Data show that gamma-Glutamyl cysteine and gamma-glutamyl valine -mediated activation of calcium-sensing receptor (CaSR) prevents tumor necrosis factor-alpha (TNF-alpha (show TNF Antibodies))-induced pro-inflammatory signaling.
Long-term activation of CaSR with cinacalcet disrupted the cadherin-catenin complex, induced cytoskeletal remodeling, actin fiber formation, and redistribution of CaSR to the nuclear area. These changes indicate a significant and complex role of CaSR in epithelial remodeling and barrier function of esophageal cells.
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.
, vomeronasal receptor F-1
, calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)
, parathyroid gland calcium-sensing receptor
, extracellular calcium-sensing receptor-like
, extracellular calcium-sensing receptor
, parathyroid Ca(2+)-sensing receptor 1
, parathyroid cell calcium-sensing receptor
, parathyroid Cell calcium-sensing receptor
, Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism)
, Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)
, G protein coupled receptor, family C, group 2, member A
, G protein-coupled receptor, family C, group 2, member A
, cation sensing receptor