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The protein encoded by CASR is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. Additionally we are shipping Calcium-Sensing Receptor Kits (43) and Calcium-Sensing Receptor Proteins (23) and many more products for this protein.
Showing 10 out of 150 products:
Cow (Bovine) Monoclonal CASR Primary Antibody for ELISA, FACS - ABIN266769
Goldsmith, Fan, Ray, Shiloach, McPhie, Rogers, Spiegel: Expression, purification, and biochemical characterization of the amino-terminal extracellular domain of the human calcium receptor. in The Journal of biological chemistry 1999
Show all 14 references for ABIN266769
Human Monoclonal CASR Primary Antibody for ELISA, FACS - ABIN250524
Handlogten, Shiraishi, Awata, Huang, Miller: Extracellular Ca(2+)-sensing receptor is a promiscuous divalent cation sensor that responds to lead. in American journal of physiology. Renal physiology 2001
Show all 4 references for ABIN250524
Human Polyclonal CASR Primary Antibody for EIA, WB - ABIN492848
Chou, Pollak, Brandi, Toss, Arnqvist, Atkinson, Papapoulos, Marx, Brown, Seidman: Mutations in the human Ca(2+)-sensing-receptor gene that cause familial hypocalciuric hypercalcemia. in American journal of human genetics 1995
Show all 3 references for ABIN492848
Human Polyclonal CASR Primary Antibody for ICC, FACS - ABIN1742166
Rácz, Kittel, Riccardi, Case, Elliott, Varga: Extracellular calcium sensing receptor in human pancreatic cells. in Gut 2002
Show all 2 references for ABIN1742166
Mouse (Murine) Polyclonal CASR Primary Antibody for WB - ABIN1881139
OSeaghdha, Yang, Glazer, Leak, Dehghan, Smith, Kao, Lohman, Hwang, Johnson, Hofman, Uitterlinden, Chen, Brown, Siscovick, Harris, Psaty, Coresh, Gudnason, Witteman, Liu, Kestenbaum, Fox, Köttgen: Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. in Human molecular genetics 2010
Show all 2 references for ABIN1881139
Human Polyclonal CASR Primary Antibody for IF (p), IHC (p) - ABIN1386858
Huang, Xiao, Tan, Xiao, Wang, Yin, Duan, Huang, Yang, Yin: Chitosan Oligosaccharide Reduces Intestinal Inflammation That Involves Calcium-Sensing Receptor (CaSR) Activation in Lipopolysaccharide (LPS)-Challenged Piglets. in Journal of agricultural and food chemistry 2016
CaSR activation may play a fundamental role in selecting specific differentiation checkpoints of neurogenesis and osteogenesis
The extracellular calcium-sensing receptor is expressed in the cumulus-oocyte complex in mammals and modulates oocyte meiotic maturation.
Calcium and the calcimimetic NPS (show NPS Antibodies) R-467 reduce CaSR mRNA expression and stimulate cell growth/proliferation in equine size-sieved umbilical cord matrix mesenchymal stem cell.
There is a significant correlation between in vitro functional impairment of the CaSR at physiologic calcium concentrations and the severity of alterations in calcium homeostasis in patients.
Calcium sensing receptor gene rs1801725 variants are not associated with susceptibility to colorectal cancer.
physiological fetal hypercalcemia, acting on the CaSR, promotes human fetal lung development via cAMP-dependent opening of CFTR (show CFTR Antibodies).
CaSR and PTH1R (show PTH1R Antibodies) signaling responses in cartilage and bone. [review]
The calcium-sensing receptor may be involved in the modulation of inflammatory processes. [review]
A986S polymorphism of CaSR is an independent predictor of PTH (show PTH Antibodies) level in normocalcemic hyperparathyroidism patients, but not in asymptomatic hyperparathyroidism.
Though this case has previously been published as a surgical case report, a full report of the medical management and underlying genetic etiology is warranted; this case underscores the importance of disclosing bi-parental heterozygosity for a gene causing severe neonatal disease particularly when treatment is available and illustrates the need for further in vitro studies of this CaSR mutation.
Emerging roles of the CaSR in intestinal homeostasis and its therapeutic potential for gut (show GUSB Antibodies) pathology. [review]
These findings demonstrate that CaSR-targeted compounds can rectify signaling disturbances caused by germline and somatic Galpha11 mutations, which respectively lead to calcium disorders and tumorigenesis; and that ADH2 (show ADH1B Antibodies)-causing Galpha11 mutations induce non-constitutive alterations in MAPK (show MAPK1 Antibodies) signaling.
CaSR-induced constitutive macropinocytosis facilitates the sentinel function of macrophages, promoting the efficient delivery of ligands to cytosolic pattern-recognition receptors.
CaSR was localized in the basolateral membrane of basolateral membrane of type-B intercalated cell and was more expressed during alkali-loading
Demonstrate a role for CaSR in cardiovascular system and suggest physiologically relevant changes in extracellular Ca(2 (show CA2 Antibodies)+) concentrations could contribute to setting blood vessel tone levels and heart rate by directly acting on the cardiovascular CaSR.
Both vitamin D and calcium are needed for protection against malignant transformation of the colon and that their effect is modulated by the presence of a functional CaSR.
fluoride might be able to affect calcium homeostasis by regulating PTH (show PTH Antibodies), PTHrP (show PTHLH Antibodies), and CaSR
the activation of CaSR in the collecting duct prevents the cyclic AMP (show TMPRSS5 Antibodies)-dependent increase in AQP2 (show AQP2 Antibodies)-phosphorylation at S256 and water permeability, counteracting the short-term vasopressin (show AVP Antibodies) response.
Deoxynivalenol induced cholecystokinin (show CCK Antibodies) and glucagon-like peptide 1 (show GCG Antibodies) release by enteroendocrine cells in mediated by casR/TRPA1 (show TRPA1 Antibodies) signaling.
Calcium-sensing receptor has a role in airway hyperresponsiveness and inflammation in allergic asthma
CaSR and OGR1 (show GPR68 Antibodies) reciprocally inhibit signaling through each other in central neurons, and that this is lost in their transformed counterparts. Acidification impairs CaSR
results demonstrate a critical tumor suppressive role of CaSR in the colon. Restoration of CaSR expression and function is linked to regulation of the balance between proliferation, differentiation, and apoptosis
Long-term activation of CaSR with cinacalcet disrupted the cadherin-catenin complex, induced cytoskeletal remodeling, actin fiber formation, and redistribution of CaSR to the nuclear area. These changes indicate a significant and complex role of CaSR in epithelial remodeling and barrier function of esophageal cells.
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.
, vomeronasal receptor F-1
, calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)
, parathyroid gland calcium-sensing receptor
, extracellular calcium-sensing receptor-like
, extracellular calcium-sensing receptor
, parathyroid Ca(2+)-sensing receptor 1
, parathyroid cell calcium-sensing receptor
, parathyroid Cell calcium-sensing receptor
, Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism)
, Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)
, G protein coupled receptor, family C, group 2, member A
, G protein-coupled receptor, family C, group 2, member A
, cation sensing receptor