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Calcium-Sensing Receptor Proteins (CASR)

The protein encoded by CASR is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. Additionally we are shipping Calcium-Sensing Receptor Antibodies (144) and Calcium-Sensing Receptor Kits (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CASR 846 P41180
CASR 24247 P48442
CASR 12374 Q9QY96
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Top Calcium-Sensing Receptor Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

CASR Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Rat (Rattus)
Mouse (Murine) ,
,

More Proteins for Calcium-Sensing Receptor (CASR) Interaction Partners

Horse (Equine) Calcium-Sensing Receptor (CASR) interaction partners

  1. CaSR activation may play a fundamental role in selecting specific differentiation checkpoints of neurogenesis and osteogenesis

  2. The extracellular calcium-sensing receptor is expressed in the cumulus-oocyte complex in mammals and modulates oocyte meiotic maturation.

  3. Calcium and the calcimimetic NPS (show NPS Proteins) R-467 reduce CaSR mRNA expression and stimulate cell growth/proliferation in equine size-sieved umbilical cord matrix mesenchymal stem cell.

Human Calcium-Sensing Receptor (CASR) interaction partners

  1. CaSR-induced constitutive macropinocytosis facilitates the sentinel function of macrophages, promoting the efficient delivery of ligands to cytosolic pattern-recognition receptors.

  2. Downregulation of CaSR may contribute to the prevention or suppression of tumor outgrowth in gastric cancer.

  3. The rs17251221 single nucleotide polymorphism of CaSR is a risk factor associated with breast cancer susceptibility, as well as a prognostic indicator.

  4. A novel naturally occurring deletion mutation within the CASR that apparently arose de novo in the father of the Autosomal dominant hypocalcemia proband.

  5. Aortic smooth muscle cells under static or strained conditions were exposed to CaSR agonists, R568, and CaSR silencing and over-expression. High Ca reduced CaSR expression. Cyclic strain or R568 prevented this. CaSR silencing enhanced calcification.

  6. the identification of a novel heterozygous loss-of-function mutation of the CASR gene in three siblings with familial hypocalciuric hypercalcaemia

  7. Results suggest that the G allele and the homozygous GG genotype of the CaSR rs17251221 polymorphism are protective against ovarian cancer and represent low risk for it.

  8. CaSR activation elevates visceral preadipocyte proliferation.

  9. these studies suggest that 14-3-3 (show YWHAQ Proteins) binding at the carboxyl terminus provides an important buffering mechanism to increase the intracellular pool of CaSR available for signaling-evoked trafficking

  10. Both vitamin D and calcium are needed for protection against malignant transformation of the colon and that their effect is modulated by the presence of a functional CaSR.

Mouse (Murine) Calcium-Sensing Receptor (CASR) interaction partners

  1. CaSR was localized in the basolateral membrane of basolateral membrane of type-B intercalated cell and was more expressed during alkali-loading

  2. Demonstrate a role for CaSR in cardiovascular system and suggest physiologically relevant changes in extracellular Ca(2 (show CA2 Proteins)+) concentrations could contribute to setting blood vessel tone levels and heart rate by directly acting on the cardiovascular CaSR.

  3. Both vitamin D and calcium are needed for protection against malignant transformation of the colon and that their effect is modulated by the presence of a functional CaSR.

  4. fluoride might be able to affect calcium homeostasis by regulating PTH (show PTH Proteins), PTHrP, and CaSR

  5. the activation of CaSR in the collecting duct prevents the cyclic AMP (show TMPRSS5 Proteins)-dependent increase in AQP2 (show AQP2 Proteins)-phosphorylation at S256 and water permeability, counteracting the short-term vasopressin (show AVP Proteins) response.

  6. Deoxynivalenol induced cholecystokinin (show CCK Proteins) and glucagon-like peptide 1 (show GCG Proteins) release by enteroendocrine cells in mediated by casR/TRPA1 (show TRPA1 Proteins) signaling.

  7. Calcium-sensing receptor has a role in airway hyperresponsiveness and inflammation in allergic asthma

  8. CaSR and OGR1 reciprocally inhibit signaling through each other in central neurons, and that this is lost in their transformed counterparts. Acidification impairs CaSR

  9. results demonstrate a critical tumor suppressive role of CaSR in the colon. Restoration of CaSR expression and function is linked to regulation of the balance between proliferation, differentiation, and apoptosis

  10. Data show that gamma-Glutamyl cysteine and gamma-glutamyl valine -mediated activation of calcium-sensing receptor (CaSR) prevents tumor necrosis factor-alpha (TNF-alpha (show TNF Proteins))-induced pro-inflammatory signaling.

Pig (Porcine) Calcium-Sensing Receptor (CASR) interaction partners

  1. Long-term activation of CaSR with cinacalcet disrupted the cadherin-catenin complex, induced cytoskeletal remodeling, actin fiber formation, and redistribution of CaSR to the nuclear area. These changes indicate a significant and complex role of CaSR in epithelial remodeling and barrier function of esophageal cells.

Calcium-Sensing Receptor (CASR) Protein Profile

Protein Summary

The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

Gene names and symbols associated with CASR

  • calcium-sensing receptor (casr)
  • calcium-sensing receptor (CASR)
  • calcium-sensing receptor (Casr)
  • calcium-sensing receptor (LOC100341543)
  • CaR protein
  • CASR protein
  • EIG8 protein
  • FHH protein
  • FIH protein
  • Gprc2a protein
  • HHC protein
  • HHC1 protein
  • HYPOC1 protein
  • NSHPT protein
  • PCAR1 protein
  • xV2R F-1 protein

Protein level used designations for CASR

calcium-sensing receptor , vomeronasal receptor F-1 , calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism) , parathyroid gland calcium-sensing receptor , extracellular calcium-sensing receptor-like , extracellular calcium-sensing receptor , parathyroid Ca(2+)-sensing receptor 1 , parathyroid cell calcium-sensing receptor , PCaR1 , parathyroid Cell calcium-sensing receptor , Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism) , Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism) , G protein coupled receptor, family C, group 2, member A , G protein-coupled receptor, family C, group 2, member A , cation sensing receptor

GENE ID SPECIES
446258 Xenopus laevis
460628 Pan troglodytes
714441 Macaca mulatta
100034084 Equus caballus
100302732 Felis catus
100459602 Pongo abelii
100483630 Ailuropoda melanoleuca
846 Homo sapiens
281038 Bos taurus
24247 Rattus norvegicus
12374 Mus musculus
100341543 Oryctolagus cuniculus
100718111 Cavia porcellus
100520980 Sus scrofa
488007 Canis lupus familiaris
418266 Gallus gallus
101112527 Ovis aries
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