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Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) Proteins (CASK)

CASK encodes a calcium/calmodulin-dependent serine protein kinase. Additionally we are shipping Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) Antibodies (75) and Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CASK 8573 O14936
CASK 12361 O70589
Rat CASK CASK 29647 Q62915
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Top Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 50 μg Log in to see 16 Days
$272.80
Details
HOST_Baculovirus infected Insect Cells Human Un-conjugated 50 μg Log in to see 16 Days
$338.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_HEK-293 Cells Human His tag   50 μg Log in to see 5 Days
$385.00
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CASK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Top referenced Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) Proteins

  1. Human CASK Protein expressed in Baculovirus infected Insect Cells - ABIN2004883 : Mukherjee, Sharma, Urlaub, Bourenkov, Jahn, Südhof, Wahl: CASK Functions as a Mg2+-independent neurexin kinase. in Cell 2008 (PubMed)
    Show all 5 references for ABIN2004883

  2. Human CASK Protein expressed in Baculovirus infected Insect Cells - ABIN2004885 : Cohen, Woods, Marfatia, Walther, Chishti, Anderson, Wood: Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells. in The Journal of cell biology 1998 (PubMed)
    Show all 5 references for ABIN2004885

More Proteins for Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) Interaction Partners

Fruit Fly (Drosophila melanogaster) Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) interaction partners

  1. Data show that Drosophila CASK is associated with both pre and postsynaptic membranes, and that loss of presynaptic CASK leads to less evoked synaptic transmission, fewer spontaneous synaptic events, and reduced synaptic vesicle cycling.

  2. Full-length CASK-beta appears to have a unique role within central circuits that control motor output

  3. Camguk localizes to synaptic regions of the brain and associates in an ATP-regulated manner with CaMKII to catalyze formation of a pool of calcium-insensitive CaMKII.

  4. The results of this study support the involvement of CAKI in neurotransmitter release and nervous system function.

  5. the Drosophila homolog of CASK/Camguk can act as a gain controller on the transition to calcium-independence in vivo.

  6. Dneurexin (DNRX (show NRXN1 Proteins)) is important for locomotion through a genetic interaction with the scaffold protein (show HOMER1 Proteins), CAKI/CMG, the Drosophila homolog of vertebrate CASK.

Human Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) interaction partners

  1. In clinical specimens, CASK was over-expressed in tumors and H. pylori positive tissues, and its mRNA levels were inversely correlated with miR (show MLXIP Proteins)-203 expression.

  2. Data indicate that patients with low calcium/calmodulin-dependent serine protein kinase (CASK) staining had a significantly better survival compared to patients with high CASK staining.

  3. The findings suggest that CASK and the truncated prestin (show SLC26A5 Proteins) splice isoform contribute to confinement of prestin (show SLC26A5 Proteins) to the basolateral region of the plasma membrane.

  4. CASK regulates CaMKII (show CAMK2G Proteins) autophosphorylation in a pathway required for memory formation.

  5. a model whereby CASK recruits FRMD7 (show FRMD7 Proteins) to the plasma membrane to promote neurite outgrowth during development of the oculomotor neural network and that defects in this interaction result in nystagmus.

  6. our findings suggest a molecular mechanism by which CASK binding regulates SAP97 (show DLG1 Proteins) conformation and its subsequent sorting and synaptic targeting of AMPARs and NMDARs during trafficking to synapses.

  7. CASK represents an intracellular gateway to regulate purinergic nociceptive signaling.

  8. An early diagnosis and be useful for medical care of females with ID and MICPCH associated with CASK mutations.

  9. CASK combines the scaffolding activity of MAGUKs with an unusual kinase activity that phosphorylates substrates recuited by the scaffolding activity.

  10. During wounding, CASK is mobilized to the plasm (show GJA1 Proteins)a membrane where it colocalizes with Cx43 and CADM1 1 hour after skin explant wounding.

Mouse (Murine) Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) interaction partners

  1. Ths data of this study implies that some phenotypic components of CASK heterozygous deletion mutation associated disorders represent systemic manifestation of metabolic stress.

  2. The findings suggest that CASK and the truncated prestin (show SLC26A5 Proteins) splice isoform contribute to confinement of prestin (show SLC26A5 Proteins) to the basolateral region of the plasma membrane.

  3. DLG1 (show DLG1 Proteins) and CASK play critical cooperative roles in maintaining the nephron progenitor population, potentially via a mechanism involving effects on FGF signaling

  4. Immunofluorescence shows colocalization of Cx43 (show GJA1 Proteins) and CASK in brain astrocytes.

  5. CASK negatively regulates PMCA4b (show ATP2B4 Proteins) by directly binding to it and JAM-A (show F11R Proteins) positively regulates it indirectly through CASK

  6. Data show that CASK expression and the appropriate localization of DLG1 and LIN7c are not essential for either epithelial polarity or intestinal homeostasis in vivo.

  7. Post-translational modifications to CASK are major regulatory steps leading to its proteasomal degradation.

  8. CASK is transcribed in mouse testis and processing may play a role in the acquisition of spserm and sperm functions.

  9. CASK and Dlg (show DLG4 Proteins) may act as a scaffold for organizing receptors and channels at the postsynaptic membrane of the neuromuscular junction.

  10. We suggest that Tbr-1 (show TBR1 Proteins)/CASK protein complex regulates expression of these downstream target genes and thus modulates neuronal activity and function.

Cow (Bovine) Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) interaction partners

  1. findings suggest that Cask plays an important role in all retinal synapses

Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) Protein Profile

Protein Summary

This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CASK

  • CASK ortholog (CASK)
  • Peripheral plasma membrane protein CASK (Bm1_33725)
  • peripheral plasma membrane protein CASK (LOAG_08350)
  • peripheral plasma membrane protein CASK (Tsp_03763)
  • calcium/calmodulin-dependent serine protein kinase b (caskb)
  • calcium/calmodulin-dependent serine protein kinase (cask)
  • calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK)
  • calcium/calmodulin-dependent serine protein kinase (MAGUK family) (Cask)
  • calcium/calmodulin-dependent serine protein kinase (MAGUK family) (cask)
  • CAGH39 protein
  • caki protein
  • camguk protein
  • Cask protein
  • CG6703 protein
  • CG13412 protein
  • CG13413 protein
  • cmg protein
  • CMG/CASK protein
  • dCASK protein
  • DLin-2 protein
  • Dmel\\CG6703 protein
  • DXPri1 protein
  • DXRib1 protein
  • FGS4 protein
  • LIN-2 protein
  • LIN2 protein
  • MICPCH protein
  • mLin-2 protein
  • MRXSNA protein
  • Pals3 protein
  • RE09582p protein
  • TNRC8 protein
  • wu:fb70g06 protein

Protein level used designations for CASK

CASK-PA , CASK-PB , CASK-PD , CASK-PE , CASK-PF , CASK-PG , CASK-PH , CG6703-PA , CG6703-PB , CG6703-PD , CG6703-PE , CG6703-PF , CG6703-PG , CG6703-PH , Calcium/calmodulin-dependent protein kinase , Camguk/CASK adaptor protein , calmodulin-dependent kinase , camguk , Peripheral plasma membrane protein CASK , peripheral plasma membrane protein CASK , calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase , hCASK , protein lin-2 homolog , trinucleotide repeat containing 8 , G-protein-coupled receptor GPR34

GENE ID SPECIES
42567 Drosophila melanogaster
6101633 Brugia malayi
9945779 Loa loa
10910490 Trichinella spiralis
100148073 Danio rerio
259195 Danio rerio
8573 Homo sapiens
12361 Mus musculus
29647 Rattus norvegicus
480887 Canis lupus familiaris
446996 Xenopus laevis
404149 Bos taurus
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