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Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.. Additionally we are shipping CAPN1 Antibodies (121) and CAPN1 Kits (7) and many more products for this protein.
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Human CAPN1 Protein expressed in Human - ABIN411905
Huang, Zhou, Saberwal, Konieczna, Horvath, Katsoulidis, Platanias, Eklund: Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription. in Molecular and cellular biology 2010
Show all 7 references for ABIN411905
CRYbetaA3/A1-crystallin has a role in preventing nuclear cataract impaired lysosomal cargo clearance and calpain activation
Capn1 (show CAPNL1 Proteins) protein and activity in mitochondria were elevated in diabetic mouse hearts. Increased mitochondrial Capn1 (show CAPNL1 Proteins) was associated with increased mitochondrial ROS (show ROS1 Proteins) generation and oxidative damage and reduced ATP5A1 (show ATP5A1 Proteins) protein and ATP synthase activity.
LOX-1 (show OLR1 Proteins) is, at least in part, responsible for the inhibitory effect of ox-LDL on macrophage migration and this process involves calpain-1 and -2.
Over-expression of Cast inhibits calpain activation and attenuates post-infarction myocardial remodeling.
Junctophilin-2 (show JPH2 Proteins) is cleaved by calpain at multiple sites, resulting in dysfunctional junctophilin-2 (show JPH2 Proteins) truncations.
Data indicate that calpain-1 up-regulation induces endoplasmic reticulum (ER) stress.
Calcitriol stimulates expression of mu-calpain (show CAPNL1 Proteins) in co-cultured mouse cells.
Data suggest that vitamin D3 up-regulates skeletal muscle fat deposition, up-regulates muscle u-calpain/Capn1 and m-calpain/Capn2 (show CAPN2 Proteins) expression, and down-regulates muscle calpastatin (show CAST Proteins) expression.
Calpain-mediated MFN2 (show MFN2 Proteins) degradation is a novel mechanism regulating mitochondrial fusion during glutamate (show GRIN1 Proteins) excitotoxicity.
in spinal cord of 30 day old mice, activation of calpain-1 produces high amounts of nNOS (show NOS1 Proteins) active species, while in 120 day old mice enhanced-prolonged activation of calpain-1 inactivates nNOS (show NOS1 Proteins) and down-regulates NR2B (show GRIN2B Proteins)
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
calpain 1, large subunit
, CANP 1
, calcium-activated neutral proteinase 1
, calpain mu-type
, calpain-1 catalytic subunit
, calpain-1 large subunit
, calpain 1