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Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.. Additionally we are shipping CAPN1 Antibodies (120) and CAPN1 Kits (11) and many more products for this protein.
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Human CAPN1 Protein expressed in Human - ABIN411905
Huang, Zhou, Saberwal, Konieczna, Horvath, Katsoulidis, Platanias, Eklund: Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription. in Molecular and cellular biology 2010
Show all 7 references for 411905
High calpain expression is associated with brain injury.
the expression of the full-length 60-kDa calcineurin (show PPP3CA Proteins) protein is down-regulated due to over-activated calpain that cleaves calcineurin (show PPP3CA Proteins) to form a 45-kDa fragment.
calpains and calpastatin (show CAST Proteins) in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (show TAGLN Proteins)-5HTT (show SLC6A4 Proteins)(+) strain) PH, were investigated.
Attenuation of atherosclerotic lesions/inflammation in ApoE (show APOE Proteins) KO mice by simvastatin might be associated with the downregulation of CD36 (show CD36 Proteins) and calpain-1.
Leukocyte calpain-1/calpain-2 (show CAPN2 Proteins) deficiency reduces angiotensin II-induced inflammation and atherosclerosis but not abdominal Aortic aneurysms in mice.
TnT3 regulates transcription of Cacna1s (show CACNA1S Proteins), the gene encoding Cav1.1 (show CACNA1S Proteins). Knocking down TnT3 in vivo downregulated Cav1.1 (show CACNA1S Proteins).
Taken together, our findings suggested that DHRS7C maintains intracellular Ca(2+) homeostasis involving the ER/SR and that functional loss of DHRS7C leads to Ca(2+) overload in the cytosol and ER/SR, resulting in enlarged cellular morphology via calpain activation
In conclusion, calpain was involved in oxygen glucose deprivation-induced RGC-5 necroptosis with the increased expression of its downstream molecule tAIF.
CRYbetaA3/A1-crystallin has a role in preventing nuclear cataract impaired lysosomal cargo clearance and calpain activation
Capn1 (show CAPNL1 Proteins) protein and activity in mitochondria were elevated in diabetic mouse hearts. Increased mitochondrial Capn1 (show CAPNL1 Proteins) was associated with increased mitochondrial ROS (show ROS1 Proteins) generation and oxidative damage and reduced ATP5A1 (show ATP5A1 Proteins) protein and ATP synthase activity.
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
calpain 1, large subunit
, CANP 1
, calcium-activated neutral proteinase 1
, calpain mu-type
, calpain-1 catalytic subunit
, calpain-1 large subunit
, calpain 1