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Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.. Additionally we are shipping CAPN1 Antibodies (132) and CAPN1 Kits (11) and many more products for this protein.
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Human CAPN1 Protein expressed in Human - ABIN411905
Huang, Zhou, Saberwal, Konieczna, Horvath, Katsoulidis, Platanias, Eklund: Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription. in Molecular and cellular biology 2010
Show all 7 Pubmed References
Our results indicate that calpain mediates cytokine-induced collagen-I synthesis and proliferation of ASMCs via the mTORC2 (show CRTC2 Proteins)/Akt (show AKT1 Proteins) signalling pathway, thereby regulating airway smooth muscle remodelling in asthma.
mutations in CAPN1 are an additional cause of ataxia in mammals, including humans.
Results indicate that calpain-1 and calpain-2 (show CAPN2 Proteins) are differentially activated in hippocampus following seizure activity, with calpain-1 activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 (show CAPN2 Proteins) is widely activated in pyramidal neurons of CA1 (show CA1 Proteins) and CA3 (show CA3 Proteins), and triggers neurodegenerative cascades.
Here we show the combined loss of glial glutamate (show GRIN1 Proteins) transporters GLT1 (show SLC1A2 Proteins) and GLAST (show SLC1A3 Proteins) in spinal cord caused motor neuronal death and hindlimb paralysis.
These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.
High calpain expression is associated with brain injury.
the expression of the full-length 60-kDa calcineurin protein is down-regulated due to over-activated calpain that cleaves calcineurin to form a 45-kDa fragment.
calpains and calpastatin (show CAST Proteins) in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (show TAGLN Proteins)-5HTT (show SLC6A4 Proteins)(+) strain) PH, were investigated.
Attenuation of atherosclerotic lesions/inflammation in ApoE (show APOE Proteins) KO mice by simvastatin might be associated with the downregulation of CD36 (show CD36 Proteins) and calpain-1.
Leukocyte calpain-1/calpain-2 (show CAPN2 Proteins) deficiency reduces angiotensin II-induced inflammation and atherosclerosis but not abdominal Aortic aneurysms in mice.
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
calpain 1, large subunit
, CANP 1
, calcium-activated neutral proteinase 1
, calpain mu-type
, calpain-1 catalytic subunit
, calpain-1 large subunit
, calpain 1