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Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (By similarity).. Additionally we are shipping Calpain 2 Antibodies (59) and Calpain 2 Kits (3) and many more products for this protein.
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Human Calpain 2 Protein expressed in HEK-293 Cells - ABIN2713061
Briz, Hsu, Li, Lee, Bi, Baudry: Calpain-2-mediated PTEN degradation contributes to BDNF-induced stimulation of dendritic protein synthesis. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Show all 3 Pubmed References
Results indicate that calpain-1 (show CAPN1 Proteins) and calpain-2 are differentially activated in hippocampus following seizure activity, with calpain-1 (show CAPN1 Proteins) activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 is widely activated in pyramidal neurons of CA1 (show CA1 Proteins) and CA3 (show CA3 Proteins), and triggers neurodegenerative cascades.
these findings identify ASAP2 (show ASAP2 Proteins) as a new target of Selk (show HSP Proteins)-dependent palmitoylation and reveal a new mechanism regulating the efficiency of FcgammaR-mediated phagocytosis.
ENaC (show SCNN1A Proteins) activity is regulated by calpain-2 proteolysis of MARCKS (show MARCKS Proteins).
calpains and calpastatin (show CAST Proteins) in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (show TAGLN Proteins)-5HTT (show SLC6A4 Proteins)(+) strain) PH, were investigated.
Leukocyte calpain-1 (show CAPN1 Proteins)/calpain-2 deficiency reduces angiotensin II-induced inflammation and atherosclerosis but not abdominal Aortic aneurysms in mice.
These results suggest that TRPV1 (show TRPV1 Proteins)/Ca(2 (show CA2 Proteins)+)/calpain 2-dependent signaling plays a dominant role in capsaicin-induced ablation of nociceptive terminals and further our understanding of the molecular mechanisms underlying the effects of capsaicin on nociceptors.
Calpain-2 modulates pulmonary vascular remodeling in pulmonary arterial hypertension.
LOX-1 (show OLR1 Proteins) is, at least in part, responsible for the inhibitory effect of ox-LDL on macrophage migration and this process involves calpain-1 (show CAPN1 Proteins) and -2.
Dicer is predominantly a Capn2 substrate. Dicer levels were altered in platelets from diabetic mice due to the cleavage of the enzyme by calpain, resulting in loss of function.
Data suggest that vitamin D3 up-regulates skeletal muscle fat deposition, up-regulates muscle m-calpain/Capn2 and u-calpain/Capn1 expression, and down-regulates muscle calpastatin expression.
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (By similarity).
80 kDa M-calpain subunit
, CANP 2
, calcium-activated neutral proteinase 2
, calpain M-type
, calpain-2 catalytic subunit
, calpain-2 large subunit
, cysteine proteinase
, m-calpain 80 kDa large subunit
, m-calpain large subunit
, calpain 2