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Calpain 3 Proteins (CAPN3)

Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. Additionally we are shipping Calpain 3 Antibodies (31) and Calpain 3 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CAPN3 12335 Q64691
Rat CAPN3 CAPN3 29155 P16259
CAPN3 825 P20807
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Top Calpain 3 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CAPN3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Calpain 3 (CAPN3) Interaction Partners

Xenopus laevis Calpain 3 (CAPN3) interaction partners

  1. our results suggest that calcium influx through mechanosensitive TRPC1 channels on filopodia activates calpain to control growth cone turning during development.

Mouse (Murine) Calpain 3 (CAPN3) interaction partners

  1. CAPN3 deficiency leads to degradation of SERCA (show ATP2A3 Proteins) proteins and Ca2 (show CA2 Proteins)+ dysregulation in the skeletal muscle.

  2. calpain 3 is necessary for ubiquitination and that it acts upstream of the ubiquitination machinery

  3. Cleavage of C-terminal titin (show TTN Proteins) by CAPN3 is associated with limb-girdle muscular dystrophy 2A and tibial muscular dystrophy.

  4. these studies reveal a novel interaction between CAPN3 and CaM (show Calm2 Proteins) and identify CaM (show Calm2 Proteins) as the first positive regulator of CAPN3 activity.

  5. data suggest that skNAC controls myoblast migration and sarcomere architecture in a calpain-dependent manner

  6. our results suggest that a component of FSHD pathogenesis may arise by over-expression of FRG1 (show FRG1 Proteins), reducing Rbfox1 (show A2BP1 Proteins) levels and leading to aberrant expression of an altered Calpain 3 protein through dysregulated splicing

  7. The Ky gene was downregulated in CAPN3 knockout muscles suggesting that Ky protease may play a complementary role in regulating muscle cytoskeleton homeostasis in response to changes in muscle activity

  8. The decrease in CaMKII (show CAMK2G Proteins) signaling in the absence of CAPN3 is associated with a reduction of muscle adaptation response.

  9. stretch-induced dynamic redistribution of p94 is dependent on its protease activity and essential to protect muscle from degeneration

  10. roles for Na(+) dependence of p94

Pig (Porcine) Calpain 3 (CAPN3) interaction partners

  1. The higher CAPN3 gene expression in less tender muscles confirmed the lack of a direct involvement of calpain 3 in meat tenderization.

Human Calpain 3 (CAPN3) interaction partners

  1. CAPN3 deficiency leads to degradation of SERCA (show ATP2A3 Proteins) proteins and Ca2 (show CA2 Proteins)+ dysregulation in the skeletal muscle.

  2. We analyzed 76 families affected with LGMD and identified 62 probands with mutations in the CANP3 gene. C.550delA was the most common mutation identified, being found in 78% of the LGMD2A families

  3. We identified four novel CAPN3 mutations and demonstrated clinical and pathological heterogeneity in Korean patients with calpainopathy.

  4. Cleavage of C-terminal titin (show TTN Proteins) by CAPN3 is associated with limb-girdle muscular dystrophy 2A and tibial muscular dystrophy.

  5. Calpain-3 over-expression induces p53 (show TP53 Proteins) activation and redox imbalance in melanoma A375 cells.

  6. Phosphorylated CAPN3 is involved in the pathology of limb-girdle muscular dystrophy type 2A through defects in myofibril integrity and/or signaling pathways.

  7. results provide evidence that WT CAPN3 can be formed by the iMOC of two different complementary CAPN3 mutants

  8. In LGMD2A muscles the activation of the atrophy programme appeared to depend mainly upon induction of the ubiquitin-proteasome system

  9. a heterozygous deletion of the entire CAPN3 gene was found in a patients with Limb-girdle muscular dystrophy type 2A

  10. The results indicate that PDGF-C (show PDGFC Proteins) upregulation and calpain-3 downregulation are involved in the aggressiveness of malignant melanoma and suggest that modulators of these proteins

Cow (Bovine) Calpain 3 (CAPN3) interaction partners

  1. 2 CAPN3 transcripts in the skeletal muscle individuals of local black cattle from Jilin, China, were identified.

  2. Calpain-system gene markers have beneficial effects on eating quality, consistent with previous findings for objective meat quality.

  3. activated Capn3 may be involved in molecular pathways leading to the overexpression of E2F3, which in turn could be responsible for urothelial tumor cell proliferation

  4. A QTL for meat tenderness is located in the Calpain 3 region of bovine chromosome 10.

Calpain 3 (CAPN3) Protein Profile

Protein Summary

Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.

Gene names and symbols associated with Calpain 3 Proteins (CAPN3)

  • calpain 3, (p94) (capn3)
  • calpain 3a, (p94) (capn3a)
  • calpain 3 (CAPN3)
  • calpain 3, (p94) (CAPN3)
  • calpain 3 (Capn3)
  • AI323605 protein
  • CANP3 protein
  • CANPL3 protein
  • Capa-3 protein
  • Capa3 protein
  • CAPN3 protein
  • LGMD2 protein
  • LGMD2A protein
  • Lp82 protein
  • Lp84 protein
  • Lp85 protein
  • MGC80925 protein
  • nCL-1 protein
  • nCL1 protein
  • p94 protein
  • SKM-CALP protein
  • SKM-CALPOV protein
  • zgc:92687 protein

Protein level used designations for Calpain 3 Proteins (CAPN3)

calpain 3 , calpain 3, (p94) , calpain-3 , lens-specific calpain Lp82 , CANP 3 , calcium-activated neutral proteinase 3 , calpain L3 , calpain p94 , muscle-specific calcium-activated neutral protease 3 , skeletal muscle specific calpain p94 , nCL-1 , new calpain 1 , skeletal muscle specific calpain , calpain p94, large [catalytic] subunit , calpain, large polypeptide L3 , muscle-specific calcium-activated neutral protease 3 large subunit , skeletal muscle-specific calpain , p94

GENE ID SPECIES
446888 Xenopus laevis
447832 Danio rerio
707913 Macaca mulatta
100008726 Oryctolagus cuniculus
12335 Mus musculus
29155 Rattus norvegicus
397349 Sus scrofa
825 Homo sapiens
281663 Bos taurus
423233 Gallus gallus
443038 Ovis aries
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