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The protein encoded by CNN2, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. Additionally we are shipping Calponin 2 Kits (12) and Calponin 2 Proteins (9) and many more products for this protein.
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Human Polyclonal CNN2 Primary Antibody for EIA, IHC (p) - ABIN951012
Hossain, Crish, Eckert, Lin, Jin: h2-Calponin is regulated by mechanical tension and modifies the function of actin cytoskeleton. in The Journal of biological chemistry 2005
Show all 4 references for 951012
Cow (Bovine) Polyclonal CNN2 Primary Antibody for WB - ABIN2784745
Gevaert, Goethals, Martens, Van Damme, Staes, Thomas, Vandekerckhove: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. in Nature biotechnology 2003
Human Monoclonal CNN2 Primary Antibody for IF, IHC - ABIN2455129
Ryer, Ronning, Erdman, Schworer, Elmore, Peeler, Nevius, Lillvis, Garvin, Franklin, Kuivaniemi, Tromp: The potential role of DNA methylation in abdominal aortic aneurysms. in International journal of molecular sciences 2015
Human Polyclonal CNN2 Primary Antibody for ELISA, WB - ABIN450046
Masuda, Tanaka, Takagi, Ohgami, Sakamaki, Shibata, Takahashi: Molecular cloning and characterization of human non-smooth muscle calponin. in Journal of biochemistry 1997
our results demonstrated that knockdown of endogenous CNN2 in AGS (show JAG1 Antibodies) cells could significantly activate cell apoptosis pathway and therefore suppress cell growth in vitro. The deletion of CNN2 might be a potential therapeutic approach to inhibit aggressive growth of gastric cancer.
h2-Calponin gene expression is further affected by the treatment of cells with Notch (show NOTCH1 Antibodies) inhibitor and activator, suggesting an upstream signaling mechanism.
Calponin 2-null macrophages and foam cells have significantly weakened cell adhesion, indicating a role of cytoskeleton regulation in macrophage functions and inflammatory responses, and a novel therapeutic target for the treatment of arterial atherosclerosis.
The novel finding that calponin 2 regulates myosin-dependent CTF (show NFIA Antibodies) in non-muscle cells demonstrates a mechanism for controlling cell motility-based functions
Expressed h2-calponin is associated with actin-tropomyosin microfilaments and may regulate cytokinesis by inhibiting the activity of the actin cytoskeleton.
H2-calponin has a role in regulating macrophage motility and phagocytosis
The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Two transcript variants encoding different isoforms have been found for this gene.
, calponin 1, basic, smooth muscle
, calponin H2, smooth muscle
, neutral calponin
, calponin 2 copy B