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The protein encoded by CNN2, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. Additionally we are shipping Calponin 2 Antibodies (96) and Calponin 2 Proteins (9) and many more products for this protein.
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Human CNN2 ELISA Kit for Sandwich ELISA - ABIN572425
Ji, Ma, Huo, Guo, Chen, Zhou: Calponin-h2 is upregulated in the tissues and plasma of patients with breast cancer. in Molecular medicine reports 2015
our results demonstrated that knockdown of endogenous CNN2 in AGS (show JAG1 ELISA Kits) cells could significantly activate cell apoptosis pathway and therefore suppress cell growth in vitro. The deletion of CNN2 might be a potential therapeutic approach to inhibit aggressive growth of gastric cancer.
h2-Calponin gene expression is further affected by the treatment of cells with Notch (show NOTCH1 ELISA Kits) inhibitor and activator, suggesting an upstream signaling mechanism.
Calponin 2-null macrophages and foam cells have significantly weakened cell adhesion, indicating a role of cytoskeleton regulation in macrophage functions and inflammatory responses, and a novel therapeutic target for the treatment of arterial atherosclerosis.
The novel finding that calponin 2 regulates myosin-dependent CTF (show NFIA ELISA Kits) in non-muscle cells demonstrates a mechanism for controlling cell motility-based functions
Expressed h2-calponin is associated with actin-tropomyosin microfilaments and may regulate cytokinesis by inhibiting the activity of the actin cytoskeleton.
H2-calponin has a role in regulating macrophage motility and phagocytosis
The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Two transcript variants encoding different isoforms have been found for this gene.
, calponin 1, basic, smooth muscle
, calponin H2, smooth muscle
, neutral calponin
, calponin 2 copy B