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Calsyntenin 1 Proteins (CLSTN1)

Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Additionally we are shipping Calsyntenin 1 Antibodies (49) and Calsyntenin 1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLSTN1 65945 Q9EPL2
CLSTN1 22883 O94985
Rat CLSTN1 CLSTN1 313717 Q6Q0N0
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Top Calsyntenin 1 Proteins at antibodies-online.com

Showing 7 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Cells Human His tag,ECD 50 μg Log in to see 16 Days
$250.80
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CLSTN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , , , ,
, , ,

More Proteins for Calsyntenin 1 (CLSTN1) Interaction Partners

Zebrafish Calsyntenin 1 (CLSTN1) interaction partners

  1. Our results suggest a model in which Clstn-1 patterns separate axonal compartments and define their ability to branch by directing trafficking of specific endosomes.

Mouse (Murine) Calsyntenin 1 (CLSTN1) interaction partners

  1. These results indicate that regulated intramembrane proteolysis of Alca by gamma-secretase regulates APP (show APP Proteins) trafficking and the production of Abeta (show APP Proteins) in vivo.

  2. these results highlight a key role for calsyntenin-1 in the transport of NMDA receptors to synaptic targets, which is necessary for the maturation of neuronal circuits during early development.

  3. Alcalpha is efficiently processed in part to minimize the inappropriate peripheral retention of kinesin-1

  4. Immunoisolated calsyntenin-1 organelles from murine brain homogenates; determined their proteome by MS. Found calsyntenin-1 organelles are endowed with components of the endosomal trafficking machinery and contained the beta-amyloid precursor protein (APP).

  5. Phosphorylation of KLC1 (show KLC1 Proteins) at serine 460 modulates binding and trafficking of calsyntenin-1.

  6. Calsyntenin-1 links a certain type of vesicular and tubulovesicular organelles to the Kinesin-1 motor.

  7. The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport.

Human Calsyntenin 1 (CLSTN1) interaction partners

  1. Increased plasma p3-Alcalpha35, a major fragment of alcalpha1, may indicate an endophenotype in Alzheimer's disease patients with progressive cognitive impairment.

  2. Increased plasma p3-alcadein (alc) alpha, evident in the early stages of cognitive impairment, suggests that alc metabolites are useful plasma biomarkers of Alzheimer's disease.

  3. findings show that calsyntenin-1 is reduced in Alzheimer's disease brains and that the extent of this reduction correlates with increased amyloid-beta

  4. CLSTN1 is a target gene of the BACH1 (show BACH1 Proteins) transcription factor according to ChIP-seq analysis in HEK (show EPHA3 Proteins) 293 cells.

  5. Phosphorylation of KLC1 (show KLC1 Proteins) at serine 460 modulates binding and trafficking of calsyntenin-1.

  6. Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation [alcalpha1, alcbeta, alcgamma]

Calsyntenin 1 (CLSTN1) Protein Profile

Protein Summary

Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals (By similarity).

Gene names and symbols associated with Calsyntenin 1 Proteins (CLSTN1)

  • calsyntenin 1 (CLSTN1)
  • calsyntenin 1 (clstn1)
  • calsyntenin 3 (clstn3)
  • calsyntenin 1 (Clstn1)
  • 1810034E21Rik protein
  • ALC-ALPHA protein
  • alcalpha1 protein
  • alcalpha2 protein
  • CALSYNTENIN-1 protein
  • CDHR12 protein
  • clstn1 protein
  • Cst-1 protein
  • CSTN1 protein
  • fm67g03 protein
  • PIK3CD protein
  • wu:fk52g02 protein
  • wu:fm67g03 protein
  • XB31alpha protein
  • zgc:56528 protein
  • zgc:153744 protein

Protein level used designations for Calsyntenin 1 Proteins (CLSTN1)

calsyntenin-1 , calsyntenin 1 , calsyntenin 3 , calsyntenin-1-like , alc-alpha , alcadein alpha , alcadein-alpha , alcadein alpha 1 , alzheimer-related cadherin-like protein , cadherin-related family member 12 , non-classical cadherin XB31alpha , non-classical cadherin XB31alpha1

GENE ID SPECIES
395372 Gallus gallus
722304 Macaca mulatta
777737 Danio rerio
100145668 Xenopus (Silurana) tropicalis
100356725 Oryctolagus cuniculus
100435584 Pongo abelii
100611252 Pan troglodytes
65945 Mus musculus
22883 Homo sapiens
313717 Rattus norvegicus
479600 Canis lupus familiaris
100520617 Sus scrofa
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