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Cancer Susceptibility Candidate 5 (CASC5) ELISA Kits

The protein encoded by CASC5 is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. Additionally we are shipping CASC5 Antibodies (37) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human CASC5 CASC5 57082 Q8NG31
Anti-Mouse CASC5 CASC5 76464  
Anti-Rat CASC5 CASC5 311327  
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More ELISA Kits for CASC5 Interaction Partners

Human Cancer Susceptibility Candidate 5 (CASC5) interaction partners

  1. Targeted Knockdown of the Kinetochore Protein D40/Knl-1 Inhibits Human Cancer in a p53 (show TP53 ELISA Kits) Status-Independent Manner

  2. We propose that CASC5 has a key role for the correct functioning of DNA damage response proteins, and a defect in this connection might affect upstream and downstream DNA damage response events as response to increased genotoxic stress.

  3. Data show sequential multisite regulation of the microtubule-associated protein KNL1-kinase-adaptor complex BUB1 (show BUB1 ELISA Kits)/BUB3 (show BUB3 ELISA Kits) interaction.

  4. Mechanisms of mitosis-specific assembly of the checkpoint platform Knl1/MIS12 (show MIS12 ELISA Kits)/NDC80 (show NDC80 ELISA Kits) at human kinetochores.

  5. PP2A (show PPP2R4 ELISA Kits)-B56 is a key phosphatase for the removal of the Mps1 (show IDUA ELISA Kits)-mediated Knl1 phosphorylations necessary for Bub1/BubR1 (show BUB1B ELISA Kits) recruitment in mammalian cells.

  6. Protein phosphatase 1 (PP1) binding to KNL1 during prometaphase reduces the levels of Bub proteins at kinetochores to approximately the level recruited by four active MELT repeats.

  7. In cells depleted of endogenous Knl1, kinetochore-targeted Knl1(1-250) suffices to restore spindle assembly checkpoint and chromosome alignment

  8. KNL1 contains an extensive array of short linear sequence modules that encompass TxxOmega and MELT motifs and that can independently localize BUB1 (show BUB1 ELISA Kits).

  9. KNL1 is a requirement for Aurora B (show AURKB ELISA Kits) activity at kinetochores and for wild-type kinetochore-MT attachment dynamics.

  10. Data provide strong evidence for CASC5 as a novel MCPH gene, and underscore the role of kinetochore integrity in proper volumetric development of the human brain.

Caenorhabditis elegans (C. elegans) Cancer Susceptibility Candidate 5 (CASC5) interaction partners

  1. Data indicate that microtubule-associated proteins KNL-1 oligomerization may coordinate with other kinetochore activities to ensure the proper organization, function, and sensory capabilities of the kinetochore-microtubule attachment.

  2. KNL-1 plays a central role in translating the initiation of kinetochore assembly

CASC5 Antigen Profile

Antigen Summary

The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11\;15)(q23\;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.

Gene names and symbols associated with CASC5

  • cancer susceptibility candidate 5 (CASC5) antibody
  • cancer susceptibility candidate 5 (Casc5) antibody
  • Protein KNL-1 (knl-1) antibody
  • 2310043D08Rik antibody
  • 5730505K17Rik antibody
  • AF15Q14 antibody
  • CT29 antibody
  • D40 antibody
  • hKNL-1 antibody
  • hSpc105 antibody
  • KNL1 antibody
  • PPP1R55 antibody
  • Rad51 antibody
  • Spc7 antibody

Protein level used designations for CASC5

cancer susceptibility candidate 5 , ALL1-fused gene from chromosome 15q14 protein , blinkin, bub-linking kinetochore protein , cancer susceptibility candidate gene 5 protein , cancer/testis antigen 29 , kinetochore null 1 homolog , kinetochore-null protein 1 , protein CASC5 , protein phosphatase 1, regulatory subunit 55 , RAD51 homolog

100071354 Equus caballus
423007 Gallus gallus
57082 Homo sapiens
76464 Mus musculus
311327 Rattus norvegicus
478260 Canis lupus familiaris
787969 Bos taurus
176164 Caenorhabditis elegans
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