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CTAG2 encodes an autoimmunogenic tumor antigen that belongs to the ESO\\/LAGE family of cancer-testis antigens. Additionally we are shipping Cancer/testis Antigen 2 Antibodies (36) and and many more products for this protein.
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The tumor suppressor function of LSAMP is most likely exerted by reducing the proliferation rate of the tumor cells, possibly by indirectly upregulating one or more of the genes HES1, CTAG2 or KLF10.
NYESO-1/LAGE-1s and PRAME (show PRAME Proteins) are targets for antigen specific T cells in chondrosarcoma following treatment with 5-Aza-2-deoxycitabine
LAGE-1a and NY-ESO-1 (show CTAG1B Proteins) homology cannot be easily exploited in an anti-NY-ESO-1 (show CTAG1B Proteins) vaccine given the low frequency of protein expression detected by IHC or serum analysis.
Spontaneous LAGE-1-specific CD4 (show CD4 Proteins)-positive T cells isolated from patients with advanced LAGE-1-positive/NY-ESO-1 (show CTAG1B Proteins)-positive melanoma are directed against three promiscuous and immunodominant epitopes.
CD4+ T cell clones specific for alternatively translated tumor antigen CAMEL have been isolated from the peripheral blood of a melanoma patient; CAMEL(81-102) is described as a naturally processed epitope recognized and presented by HLA-DR11 and HLA-DR12.
Data showed aberrant expression of NY-ESO-1 (show CTAG1B Proteins) and LAGE-1 by IHC/RT-PCR in a significant proportion of epithelial ovarian cancer patients.
Data support the immunogenicity of NY-ESO-1 (show CTAG1B Proteins)/LAGE-1 ORF2 gene products and clearly demonstrate their capability to stimulate T-helper 1 type CD4 (show CD4 Proteins)+ T cells.
LAGE-1 expression was more frequently found in squamous cell carcinoma than in adenocarcinoma.
Isolation of CD4 (show CD4 Proteins)+ T cell clones from T cell cultures of two healthy donors leads to identification of four naturally processed HLA-DR-binding CAMEL epitopes, interesting peptides to investigate for future cancer immunotherapy.
LAGE-1 expression was detected in esophageal cancer by cDNA RDA. LAGE-1 might have the potential to be a target antigen for anti-tumoral immunotherapy in esophageal cancers because of its tumor-specific expression similar to that of MAGE (show MAGEB10 Proteins)-A1.
This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO\\/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID 10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants.
CTL-recognized antigen on melanoma
, LAGE-1a protein
, autoimmunogenic cancer/testis antigen NY-ESO-2
, cancer/testis antigen 6.2
, cancer/testis antigen family 6, member 2a
, cancer/testis antigen family 6, member 2b
, l antigen family member 1