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Carbamoyl-Phosphate Synthase 1, Mitochondrial Proteins (CPS1)

The mitochondrial enzyme encoded by CPS1 catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. Additionally we are shipping CPS1 Antibodies (61) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CPS1 1373 P31327
CPS1 227231 Q8C196
Rat CPS1 CPS1 497840 P07756
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Top CPS1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CPS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) Interaction Partners

Xenopus laevis Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) interaction partners

Human Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) interaction partners

  1. Molecular structure of CPS1 has been deciphered.

  2. CPS1 and CPS1IT1 may be potential prognostic indicators for patients with intrahepatic cholangiocarcinoma.

  3. CPS1 is involved in the urea cycle in weight maintenance.

  4. More HCC (show FAM126A Proteins) cells could be identified by the antibody cocktail for CPS1 and P-CK compared with a single antibody.

  5. characterized the only currently known recurrent CPS1 mutation, p.Val1013del found in eleven unrelated patients of Turkish descent; mutation p.V1013del inactivates CPS1 but does not render the enzyme grossly unstable or insoluble

  6. Overexpression of CPS1 is associated with rectal cancers.

  7. study examined patient characteristics, including genetic polymorphism, to identify risk factors associated with development of hyperammonemia during valproic acid-based therapy; found CPS1 4217C>A polymorphism may not be associated with development of hyperammonemia in Japanese population

  8. Findings support the disease-causing role of the mutations reported to affect the CPS1 deficiency, revealing a key role of the small CPS1 domain of unknown function (UFSD) for proper enzyme folding.

  9. CPS1 becomes readily detectable upon hepatocyte apoptotic and necrotic death. Its abundance and short serum half-life suggest that it may be a useful prognostic biomarker in acute liver injury.

  10. Data show that carbamoyl phosphate synthetase 1, an enzyme involved in the urea cycle, 8-oxoguanine DNA glycosylase 1 (show OGG1 Proteins) and DNA polymerase beta (show POLB Proteins), enzymes involved in DNA repair, were expressed at higher levels in Batten disease cells than in normal cells.

Mouse (Murine) Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) interaction partners

  1. these data suggest that AhR (show AHR Proteins) activation promotes CPS1 recruitment to DNA enhancer sites in the genome, resulting in a specific enzyme-independent post-translational modification of the linker histone H1 (show H1F0 Proteins) protein (H1K34hcit), pivotal in altering local chromatin structure and transcriptional activation.

  2. The results suggest that elevated isoaspartate and CPS-1, and reduced CA-III (show CA3 Proteins) levels could serve as biomarkers of hepatocellular injury.

  3. CPS1 becomes readily detectable upon hepatocyte apoptotic and necrotic death. Its abundance and short serum half-life suggest that it may be a useful prognostic biomarker in acute liver injury.

  4. Taken together with previous findings regarding CPS1 structure and function, homology modeling of mouse CPS1 suggested that nitration at Y1450 in an alpha-helix of allosteric domain prevents activation of CPS1 by its activator, N-acetyl-l-glutamate (show GRIN1 Proteins).

  5. Because ammonia generated during fasting is toxic, SIRT5 (show SIRT5 Proteins) protein might play a protective role by converting ammonia to non-toxic urea through deacetylation and activation of CPS1.

  6. Y-box binding protein-1 (show YBX1 Proteins) down-regulates expression of carbamoyl phosphate synthetase-I by suppressing CCAAT enhancer-binding protein-alpha (show CEBPA Proteins) function in mice.

  7. SIRT5 (show SIRT5 Proteins) deacetylates CPS1 and upregulates its activity

CPS1 Protein Profile

Protein Summary

The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation.

Gene names and symbols associated with CPS1

  • carbamoyl-phosphate synthase 1, mitochondrial (cps1)
  • carbamoyl-phosphate synthase 1, mitochondrial (CPS1)
  • carbamoyl-phosphate synthetase 1 (Cps1)
  • 4732433M03Rik protein
  • cps protein
  • CPSASE1 protein
  • D1Ucla3 protein

Protein level used designations for CPS1

carbamoyl-phosphate synthase [ammonia], mitochondrial , carbamoyl-phosphate synthetase III , carbamoyl-phosphate synthase 1, mitochondrial , carbamoyl-phosphate synthetase 1, mitochondrial , carbamoyl-phosphate synthase [ammonia], mitochondrial-like , carbamoyl-phosphate synthetase I , carbamoyl phosphate synthetase 1 , carbamyl phosphate synthetase 1 , carbamoylphosphate synthetase I , CPSase I , carbamyl phosphate synthetase I , carboamyl-phosphate synthetase 1

GENE ID SPECIES
100136758 Oncorhynchus mykiss
100402602 Callithrix jacchus
488506 Canis lupus familiaris
510506 Bos taurus
738670 Pan troglodytes
100050116 Equus caballus
733340 Xenopus laevis
428994 Gallus gallus
1373 Homo sapiens
227231 Mus musculus
497840 Rattus norvegicus
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