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anti-Carbohydrate Antigen 15-3 (CA15-3) Antibodies

CA15-3 encodes a membrane-bound protein that is a member of the mucin family.

list all antibodies Gene Name GeneID UniProt
Anti-Human CA15-3 CA15-3 4582 P15941
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More Antibodies against Carbohydrate Antigen 15-3 Interaction Partners

Human Carbohydrate Antigen 15-3 (CA15-3) interaction partners

  1. MUC1 (show MUC1 Antibodies) rs4072037 A/A genotype is associated with more severe pulmonary dysfunction and a higher rate of disease progression in PAP (show REG3A Antibodies) patients.

  2. Our findings suggested that MUC1 (show MUC1 Antibodies) plays an important role in CCL21 (show CCL21 Antibodies)-CCR7 (show CCR7 Antibodies)-induced lymphatic metastasis and may serve as a therapeutic target in esophageal squamous cell carcinoma .

  3. The existence of IgG autoantibodies against aberrantly glycosylated MUC1 (show MUC1 Antibodies) may have a protective role and may contribute to a better prognosis in some breast cancer patients.

  4. MUC1 (show MUC1 Antibodies) gene silencing induces growth inhibition in SMMC7721 cells through Baxmediated mitochondrial and caspase-8 (show CASP8 Antibodies)-mediated death receptor apoptotic pathways.

  5. Data identified significantly lower expression of miR (show MLXIP Antibodies)-1291 in esophageal squamous cell carcinoma (ESCC) and acts as a tumor suppressor by targeting MUC1 (show MUC1 Antibodies).

  6. A simple diagnostic index including epithelial membrane antigen and fibronectin (show FN1 Antibodies) levels can be used for early detection of hepatocellular carcinoma.

  7. MUC1 expression significantly correlated with that of MYC and its target genes in human KRAS mutant NSCLC tumors.

  8. Studies demonstrated that MUC1 (show MUC1 Antibodies)-mediated JNK (show MAPK8 Antibodies) activation not only enhances the phosphorylation of Smad2 (show SMAD2 Antibodies) C-terminal at Ser (show SIGLEC1 Antibodies)-465/467 site (Smad2C) through TGF-beta (show TGFB1 Antibodies)/TbetaRI (show TGFBR1 Antibodies), but also enhances the phosphorylation of Smad2 (show SMAD2 Antibodies) linker region at Ser (show SIGLEC1 Antibodies)-245/250/255 site.

  9. the diagnostic value of serum cancer antigen (CA)125, CA19-9 and CA15-3 concentrations in endometriosis, was evaluated.

  10. Genetic Variants of MUC1 (show MUC1 Antibodies) Gene are not Associated with Colorectal Cancer.

Carbohydrate Antigen 15-3 (CA15-3) Antigen Profile

Protein Summary

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with CA15-3

  • mucin 1 (MUC1) antibody
  • mucin 1, cell surface associated (MUC1) antibody
  • CA 15-3 antibody
  • CD227 antibody
  • EMA antibody
  • H23AG antibody
  • KL-6 antibody
  • MAM6 antibody
  • MCKD1 antibody
  • MUC-1 antibody
  • MUC-1/SEC antibody
  • MUC-1/X antibody
  • MUC1 antibody
  • MUC1/ZD antibody
  • PEM antibody
  • PEMT antibody
  • PUM antibody

Protein level used designations for CA15-3

mucin 1 , DF3 antigen , H23 antigen , breast carcinoma-associated antigen DF3 , cancer antigen 15-3 , carcinoma-associated mucin , episialin , krebs von den Lungen-6 , mucin 1, transmembrane , mucin-1 , peanut-reactive urinary mucin , polymorphic epithelial mucin , tumor associated epithelial mucin , tumor-associated epithelial membrane antigen , tumor-associated mucin

100294522 Felis catus
4582 Homo sapiens
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