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anti-Carbonic Anhydrase IX (CA9) Antibodies

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Additionally we are shipping Carbonic Anhydrase IX Kits (32) and Carbonic Anhydrase IX Proteins (22) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CA9 230099 Q8VHB5
CA9 313495  
CA9 768 Q16790
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Top anti-Carbonic Anhydrase IX Antibodies at antibodies-online.com

Showing 10 out of 264 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of CA9/G250:78-89 (ABIN390038) in HepG2 cell line lysates (35 µg/lane). CA9 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IF, WB Western blot analysis of CA9 antibody (Center) (ABIN390041) in Hela cell line lysates (35 µg/lane). CA9 (arrow) was detected using the purified polyclonal antibody. Flow cytometric analysis of hela cells using CA9 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated FACS, ELISA, WB 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Mouse Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Dog Rabbit Un-conjugated ChIP, ELISA, FACS, GS, ICC, IF, IHC, IHC (fro), IHC (p), SimWes, WB Immunocytochemistry/Immunofluorescence: Carbonic Anhydrase IX/CA9 Antibody [ABIN151877] - Analysis of Biotin conjugate of ABIN151877. Human RCC tumor cryosections using ABIN151877 (Panel A). Panel B shows staining with normal rabbit serum. Simple Western: Carbonic Anhydrase IX/CA9 Antibody [ABIN151877] - Simple Western lane view shows a specific band for CAIX in 0.1 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. 0.1 mL Log in to see 5 to 7 Days
$473.81
Details
Human Mouse Un-conjugated FACS, IHC, WB HEK293T cells transfected with either pCMV6-ENTRY CA9 (RC204839) (Red) or empty vector control plasmid (Blue) were immunostained with anti-CA9 mouse monoclonal (ABIN2452557, Dilution 1:1,000), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CA9 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-CA9. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Mouse Fluorescein FACS Detection of Carbonic Anhydrase IX/CA9 in U-87 MG Human Cell Line by Flow Cytometry. U-87 MG human glioblastoma/ astrocytoma cell line was stained with Mouse Anti-Human Carbonic Anhydrase IX/CA9 Fluorescein-conjugated Monoclonal Antibody. 100 Tests Log in to see 6 to 7 Days
$334.69
Details
Human Mouse Un-conjugated CyTOF, ELISA, FACS, ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: Carbonic Anhydrase IX/CA9 Antibody (2D3) [NBP1-51691] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti-CA9 (2D3) [NBP1-51691] at a 1:200 dilution overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:500 dilution. Actin was detected with Phalloidin 568 (Red) at a 1:200 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective. Immunohistochemistry-Paraffin: Carbonic Anhydrase IX/CA9 Antibody (2D3) [NBP1-51691] - Immunohistochemical analysis of paraffin-embedded lung tissues (left) and colonic tissues (right) using Carbonic Anhydrase IX mouse mAb with DAB staining. 0.1 mL Log in to see 5 to 7 Days
$408.19
Details

CA9 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Carbonic Anhydrase IX Antibodies

  1. Dog (Canine) Polyclonal CA9 Primary Antibody for ChIP, ELISA - ABIN151877 : Kaidi, Moorghen, Williams, Paraskeva: Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia? in Gut 2007 (PubMed)
    Show all 128 references for ABIN151877

  2. Human Polyclonal CA9 Primary Antibody for EIA, WB - ABIN358546 : Grabmaier, A de Weijert, Verhaegh, Schalken, Oosterwijk: Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. in Oncogene 2004 (PubMed)
    Show all 5 references for ABIN358546

  3. Human Polyclonal CA9 Primary Antibody for FACS, IF - ABIN390041 : Hedley, Pintilie, Woo, Morrison, Birle, Fyles, Milosevic, Hill: Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas. in Clinical cancer research : an official journal of the American Association for Cancer Research 2003 (PubMed)
    Show all 3 references for ABIN390041

  4. Human Polyclonal CA9 Primary Antibody for WB - ABIN390038 : Kaluzová, Kaluz, Lerman, Stanbridge: DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX. in Molecular and cellular biology 2004 (PubMed)
    Show all 3 references for ABIN390038

  5. Human Monoclonal CA9 Primary Antibody for IHC, ELISA - ABIN1724883 : Pinheiro, Sousa, Albergaria, Paredes, Dufloth, Vieira, Schmitt, Baltazar: GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression. in Histology and histopathology 2011 (PubMed)
    Show all 2 references for ABIN1724883

  6. Human Monoclonal CA9 Primary Antibody for FACS, ELISA - ABIN1724882 : Neumeister, Sullivan, Lindner, Lezon-Geyda, Li, Zavada, Martel, Glazer, Tuck, Rimm, Harris: Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer. in Breast cancer research and treatment 2012 (PubMed)
    Show all 2 references for ABIN1724882

  7. Human Polyclonal CA9 Primary Antibody for IF (p), IHC (p) - ABIN752773 : Gogiraju, Xu, Bochenek, Steinbrecher, Lehnart, Wenzel, Kessel, Zeisberg, Dobbelstein, Schäfer: Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice. in Journal of the American Heart Association 2015 (PubMed)

  8. Human Monoclonal CA9 Primary Antibody for FACS, IHC - ABIN2452557 : Wang, Cheng, Liu, Zhang, Li, Li: CREB is a key negative regulator of carbonic anhydrase IX (CA9) in gastric cancer. in Cellular signalling 2015 (PubMed)

  9. Human Monoclonal CA9 Primary Antibody for FACS - ABIN4897691 : McIntyre, Patiar, Wigfield, Li, Ledaki, Turley, Leek, Snell, Gatter, Sly, Vaughan-Jones, Swietach, Harris: Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012 (PubMed)

More Antibodies against Carbonic Anhydrase IX Interaction Partners

Mouse (Murine) Carbonic Anhydrase IX (CA9) interaction partners

  1. Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors.

  2. constitutive activation of the NF-kappaB (show NFKB1 Antibodies) pathway in CAIX-depleted cells restored G-CSF (show CSF3 Antibodies) secretion

  3. Downregulation of carbonic anhydrase IX promotes Col10a1 (show COL10A1 Antibodies) expression in chondrocytes.

  4. CA IX may directly or indirectly play novel functions in brain tissue.

  5. Data show that CA9, GLUT1 (show SLC2A1 Antibodies) and LOX (show LOX Antibodies) mRNA levels were equally and strongly correlated to hypoxic extent in FaDudd, and the same profile was observed for CA9 and GLUT1 (show SLC2A1 Antibodies), but not LOX (show LOX Antibodies), in SCCVII tumors.

  6. a novel role for CA IX in the regulation of immunologic processes and digestion

  7. although CA IX-deficiency is not a tumor-promoting factor per se, it induces glandular atrophy in the body mucosa, a lesion which is considered to be a preneoplastic alteration in the stomach

  8. These results suggest that the loss of function of cytosolic CA II (show CA2 Antibodies) in the stomach of Car2 (show CA2 Antibodies)-/- mice leads to up-regulation of an extracellular CA, namely CA IX, which is expressed on the cell surface of the gastric epithelium.

  9. CA9 may regulate ion and pH homeostasis within the developing embryo.

  10. CA9 has chaperone-like functions and CA9 shed from tumors may play a direct role in stimulating an adaptive immune response

Human Carbonic Anhydrase IX (CA9) interaction partners

  1. The diagnostic accuracy of CA9 expression for clear cell renal cell carcinoma (show MOK Antibodies) was 100%.

  2. High expression of CA IX was associated with pancreatic cancer.

  3. CAIX mRNA expression was significantly higher (p < 0.05) in hypoxia for all cell lines, which was in agreement with protein expression by ICC. CAXII expression was mixed, with a modest hypoxia-related increase in two cell lines (p < 0.05) and no change in others.

  4. We also demonstrated that the cell-surface CA IX level dropped during the death progress due to an increased ECD (show SHFM1 Antibodies) shedding, which required a functional ADAM17 (show ADAM17 Antibodies). Inhibitors of metalloproteinases reduced CA IX ECD (show SHFM1 Antibodies) shedding, but not apoptosis.

  5. In neuroblastoma (show ARHGEF16 Antibodies) cells, CAIX and PGK1 (show PGK1 Antibodies) expression is up regulated under hypoxia and correlates with response to targeted anti-proliferative treatment.

  6. Flow cytometrically sorted CA9+ population showed increased mRNA level of a Wnt (show WNT2 Antibodies) signaling factor AXIN2 (show AXIN2 Antibodies). In conclusion, these observations indicate that CA9 expression in normal crypt base cells has association with intestinal epithelial stemness

  7. We used cobalt chloride (CoCl2) as a hypoxia-mimetic agent and found that the expression of HIF-1a (show HIF1A Antibodies) protein, CA IX mRNA and protein, is effectively upregulated, except for HIF-1a (show HIF1A Antibodies) mRNA.

  8. We conclude that CA9/miR34 interplay shares in the hypoxic regulation of mammospheres and therefore, may play a relevant role in the hypoxic breast cancer stem cell niche.

  9. Knockdown of CAIX significantly reduced proliferation of cancer cells, suggesting that rapid efflux of lactate and H(+), as enhanced by CAIX, contributes to cancer cell survival under hypoxic conditions.

  10. Data indicate that carbonic anhydrase IX (CAIX) inhibition as a relevant therapeutic goal in breast cancer, targeting the migratory, invasive, and metastatic potential of this disease.

Carbonic Anhydrase IX (CA9) Antigen Profile

Protein Summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.

Gene names and symbols associated with CA9

  • carbonic anhydrase IX (CA9) antibody
  • carbonic anhydrase 9 (CAH9) antibody
  • carbonic anhydrase 9 (Car9) antibody
  • carbonic anhydrase IX (LOC100337777) antibody
  • Ca9 antibody
  • CAIX antibody
  • MN antibody
  • MN/CA9 antibody

Protein level used designations for CA9

carbonic anhydrase IX , carbonic anhydrase 9 , CA-IX , carbonate dehydratase IX , membrane antigen MN homolog , P54/58N , RCC-associated antigen G250 , RCC-associated protein G250 , carbonic dehydratase , membrane antigen MN , pMW1 , renal cell carcinoma-associated antigen G250

GENE ID SPECIES
473223 Pan troglodytes
511923 Bos taurus
5726457 Chlamydomonas reinhardtii
230099 Mus musculus
313495 Rattus norvegicus
768 Homo sapiens
611933 Canis lupus familiaris
100152792 Sus scrofa
770004 Gallus gallus
100337777 Oryctolagus cuniculus
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