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Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Additionally we are shipping Carbonic Anhydrase IX Kits (32) and Carbonic Anhydrase IX Proteins (22) and many more products for this protein.
Showing 10 out of 264 products:
Dog (Canine) Polyclonal CA9 Primary Antibody for ChIP, ELISA - ABIN151877
Kaidi, Moorghen, Williams, Paraskeva: Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia? in Gut 2007
Show all 128 references for ABIN151877
Human Polyclonal CA9 Primary Antibody for EIA, WB - ABIN358546
Grabmaier, A de Weijert, Verhaegh, Schalken, Oosterwijk: Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. in Oncogene 2004
Show all 5 references for ABIN358546
Human Polyclonal CA9 Primary Antibody for FACS, IF - ABIN390041
Hedley, Pintilie, Woo, Morrison, Birle, Fyles, Milosevic, Hill: Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas. in Clinical cancer research : an official journal of the American Association for Cancer Research 2003
Show all 3 references for ABIN390041
Human Polyclonal CA9 Primary Antibody for WB - ABIN390038
Kaluzová, Kaluz, Lerman, Stanbridge: DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX. in Molecular and cellular biology 2004
Show all 3 references for ABIN390038
Human Monoclonal CA9 Primary Antibody for IHC, ELISA - ABIN1724883
Pinheiro, Sousa, Albergaria, Paredes, Dufloth, Vieira, Schmitt, Baltazar: GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression. in Histology and histopathology 2011
Show all 2 references for ABIN1724883
Human Monoclonal CA9 Primary Antibody for FACS, ELISA - ABIN1724882
Neumeister, Sullivan, Lindner, Lezon-Geyda, Li, Zavada, Martel, Glazer, Tuck, Rimm, Harris: Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer. in Breast cancer research and treatment 2012
Show all 2 references for ABIN1724882
Human Polyclonal CA9 Primary Antibody for IF (p), IHC (p) - ABIN752773
Gogiraju, Xu, Bochenek, Steinbrecher, Lehnart, Wenzel, Kessel, Zeisberg, Dobbelstein, Schäfer: Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice. in Journal of the American Heart Association 2015
Human Monoclonal CA9 Primary Antibody for FACS, IHC - ABIN2452557
Wang, Cheng, Liu, Zhang, Li, Li: CREB is a key negative regulator of carbonic anhydrase IX (CA9) in gastric cancer. in Cellular signalling 2015
Human Monoclonal CA9 Primary Antibody for FACS - ABIN4897691
McIntyre, Patiar, Wigfield, Li, Ledaki, Turley, Leek, Snell, Gatter, Sly, Vaughan-Jones, Swietach, Harris: Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors.
constitutive activation of the NF-kappaB (show NFKB1 Antibodies) pathway in CAIX-depleted cells restored G-CSF (show CSF3 Antibodies) secretion
Downregulation of carbonic anhydrase IX promotes Col10a1 (show COL10A1 Antibodies) expression in chondrocytes.
CA IX may directly or indirectly play novel functions in brain tissue.
Data show that CA9, GLUT1 (show SLC2A1 Antibodies) and LOX (show LOX Antibodies) mRNA levels were equally and strongly correlated to hypoxic extent in FaDudd, and the same profile was observed for CA9 and GLUT1 (show SLC2A1 Antibodies), but not LOX (show LOX Antibodies), in SCCVII tumors.
a novel role for CA IX in the regulation of immunologic processes and digestion
although CA IX-deficiency is not a tumor-promoting factor per se, it induces glandular atrophy in the body mucosa, a lesion which is considered to be a preneoplastic alteration in the stomach
These results suggest that the loss of function of cytosolic CA II (show CA2 Antibodies) in the stomach of Car2 (show CA2 Antibodies)-/- mice leads to up-regulation of an extracellular CA, namely CA IX, which is expressed on the cell surface of the gastric epithelium.
CA9 may regulate ion and pH homeostasis within the developing embryo.
CA9 has chaperone-like functions and CA9 shed from tumors may play a direct role in stimulating an adaptive immune response
The diagnostic accuracy of CA9 expression for clear cell renal cell carcinoma (show MOK Antibodies) was 100%.
High expression of CA IX was associated with pancreatic cancer.
CAIX mRNA expression was significantly higher (p < 0.05) in hypoxia for all cell lines, which was in agreement with protein expression by ICC. CAXII expression was mixed, with a modest hypoxia-related increase in two cell lines (p < 0.05) and no change in others.
We also demonstrated that the cell-surface CA IX level dropped during the death progress due to an increased ECD (show SHFM1 Antibodies) shedding, which required a functional ADAM17 (show ADAM17 Antibodies). Inhibitors of metalloproteinases reduced CA IX ECD (show SHFM1 Antibodies) shedding, but not apoptosis.
In neuroblastoma (show ARHGEF16 Antibodies) cells, CAIX and PGK1 (show PGK1 Antibodies) expression is up regulated under hypoxia and correlates with response to targeted anti-proliferative treatment.
Flow cytometrically sorted CA9+ population showed increased mRNA level of a Wnt (show WNT2 Antibodies) signaling factor AXIN2 (show AXIN2 Antibodies). In conclusion, these observations indicate that CA9 expression in normal crypt base cells has association with intestinal epithelial stemness
We used cobalt chloride (CoCl2) as a hypoxia-mimetic agent and found that the expression of HIF-1a (show HIF1A Antibodies) protein, CA IX mRNA and protein, is effectively upregulated, except for HIF-1a (show HIF1A Antibodies) mRNA.
We conclude that CA9/miR34 interplay shares in the hypoxic regulation of mammospheres and therefore, may play a relevant role in the hypoxic breast cancer stem cell niche.
Knockdown of CAIX significantly reduced proliferation of cancer cells, suggesting that rapid efflux of lactate and H(+), as enhanced by CAIX, contributes to cancer cell survival under hypoxic conditions.
Data indicate that carbonic anhydrase IX (CAIX) inhibition as a relevant therapeutic goal in breast cancer, targeting the migratory, invasive, and metastatic potential of this disease.
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
carbonic anhydrase IX
, carbonic anhydrase 9
, carbonate dehydratase IX
, membrane antigen MN homolog
, RCC-associated antigen G250
, RCC-associated protein G250
, carbonic dehydratase
, membrane antigen MN
, renal cell carcinoma-associated antigen G250