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Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Additionally we are shipping Carbonic Anhydrase IX Kits (39) and Carbonic Anhydrase IX Proteins (22) and many more products for this protein.
Showing 10 out of 173 products:
Human Polyclonal CA9 Primary Antibody for EIA, WB - ABIN358546
Grabmaier, A de Weijert, Verhaegh, Schalken, Oosterwijk: Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. in Oncogene 2004
Show all 5 references for ABIN358546
Human Polyclonal CA9 Primary Antibody for WB - ABIN390039
Hedley, Pintilie, Woo, Morrison, Birle, Fyles, Milosevic, Hill: Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas. in Clinical cancer research : an official journal of the American Association for Cancer Research 2003
Show all 3 references for ABIN390039
Human Polyclonal CA9 Primary Antibody for WB - ABIN390038
Kaluzová, Kaluz, Lerman, Stanbridge: DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX. in Molecular and cellular biology 2004
Show all 3 references for ABIN390038
Human Monoclonal CA9 Primary Antibody for FACS, ELISA - ABIN1724882
Pinheiro, Sousa, Albergaria, Paredes, Dufloth, Vieira, Schmitt, Baltazar: GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression. in Histology and histopathology 2011
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Human Monoclonal CA9 Primary Antibody for IHC, ELISA - ABIN1724883
Neumeister, Sullivan, Lindner, Lezon-Geyda, Li, Zavada, Martel, Glazer, Tuck, Rimm, Harris: Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer. in Breast cancer research and treatment 2012
Show all 2 references for ABIN1724883
Human Polyclonal CA9 Primary Antibody for IF (p), IHC (p) - ABIN752773
Gogiraju, Xu, Bochenek, Steinbrecher, Lehnart, Wenzel, Kessel, Zeisberg, Dobbelstein, Schäfer: Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice. in Journal of the American Heart Association 2015
Human Monoclonal CA9 Primary Antibody for FACS, IHC - ABIN2452557
Wang, Cheng, Liu, Zhang, Li, Li: CREB is a key negative regulator of carbonic anhydrase IX (CA9) in gastric cancer. in Cellular signalling 2015
Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors.
constitutive activation of the NF-kappaB (show NFKB1 Antibodies) pathway in CAIX-depleted cells restored G-CSF (show CSF3 Antibodies) secretion
Downregulation of carbonic anhydrase IX promotes Col10a1 (show COL10A1 Antibodies) expression in chondrocytes.
CA IX may directly or indirectly play novel functions in brain tissue.
Data show that CA9, GLUT1 (show SLC2A1 Antibodies) and LOX (show LOX Antibodies) mRNA levels were equally and strongly correlated to hypoxic extent in FaDudd, and the same profile was observed for CA9 and GLUT1 (show SLC2A1 Antibodies), but not LOX (show LOX Antibodies), in SCCVII tumors.
a novel role for CA IX in the regulation of immunologic processes and digestion
although CA IX-deficiency is not a tumor-promoting factor per se, it induces glandular atrophy in the body mucosa, a lesion which is considered to be a preneoplastic alteration in the stomach
These results suggest that the loss of function of cytosolic CA II (show CA2 Antibodies) in the stomach of Car2 (show CA2 Antibodies)-/- mice leads to up-regulation of an extracellular CA, namely CA IX, which is expressed on the cell surface of the gastric epithelium.
CA9 may regulate ion and pH homeostasis within the developing embryo.
CA9 has chaperone-like functions and CA9 shed from tumors may play a direct role in stimulating an adaptive immune response
Flow cytometrically sorted CA9+ population showed increased mRNA level of a Wnt (show WNT2 Antibodies) signaling factor AXIN2 (show AXIN2 Antibodies). In conclusion, these observations indicate that CA9 expression in normal crypt base cells has association with intestinal epithelial stemness
We used cobalt chloride (CoCl2) as a hypoxia-mimetic agent and found that the expression of HIF-1a (show HIF1A Antibodies) protein, CA IX mRNA and protein, is effectively upregulated, except for HIF-1a (show HIF1A Antibodies) mRNA.
We conclude that CA9/miR34 interplay shares in the hypoxic regulation of mammospheres and therefore, may play a relevant role in the hypoxic breast cancer stem cell niche.
Knockdown of CAIX significantly reduced proliferation of cancer cells, suggesting that rapid efflux of lactate and H(+), as enhanced by CAIX, contributes to cancer cell survival under hypoxic conditions.
Data indicate that carbonic anhydrase IX (CAIX) inhibition as a relevant therapeutic goal in breast cancer, targeting the migratory, invasive, and metastatic potential of this disease.
Inhibition of CA9 expression or activity resulted in radiation sensitization of RCC (show XRCC1 Antibodies) in a preclinical mouse model.
Urinary CAIX has a high sensitivity and specificity for diagnosing urothelial bladder cancer.
The intrinsic thermodynamic parameters of compound binding to CA IX helped to draw the compound structure to thermodynamics relationship.
our study showed that the expression of CAIX in oral squamous cell carcinoma (OSCC) samples can predict the progression of OSCC and survival of OSCC patients in Taiwan
we aimed to determine the effect of immunohistochemical staining of ezrin (show EZR Antibodies), carbonic anhydrase IX (CA IX), and neuropilin-2 (show NRP2 Antibodies) on the prognosis of patients diagnosed with metastatic RCC (show XRCC1 Antibodies) who were treated with TKIs between January 2007 and June 2012.
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
carbonic anhydrase IX
, carbonic anhydrase 9
, carbonate dehydratase IX
, membrane antigen MN homolog
, RCC-associated antigen G250
, RCC-associated protein G250
, carbonic dehydratase
, membrane antigen MN
, renal cell carcinoma-associated antigen G250