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Carbonic Anhydrase IX Proteins (CA9)

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Additionally we are shipping Carbonic Anhydrase IX Antibodies (257) and Carbonic Anhydrase IX Kits (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CA9 230099 Q8VHB5
Rat CA9 CA9 313495  
CA9 768 Q16790
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Top Carbonic Anhydrase IX Proteins at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 50 μg Log in to see 2 to 3 Days
$385.00
Details
HOST_Human Cells Human Fc Tag 10 μg Log in to see 16 Days
$206.80
Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 16 Days
$206.80
Details
HOST_Human Cells Dog His tag 10 μg Log in to see 16 Days
$206.80
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 9 to 11 Days
$242.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_HEK-293 Human His tag 10 μg Log in to see 2 to 3 Days
$262.50
Details

CA9 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
,
Human , , , , , ,
, , , ,

Top referenced Carbonic Anhydrase IX Proteins

  1. Dog (Canine) CA9 Protein expressed in Human Cells - ABIN2008868 : Pastorek, Pastoreková, Callebaut, Mornon, Zelník, Opavský, Zatovicová, Liao, Portetelle, Stanbridge: Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment. in Oncogene 1994 (PubMed)
    Show all 5 references for ABIN2008868

  2. Mouse (Murine) CA9 Protein expressed in Human Cells - ABIN2008118 : Opavský, Pastoreková, Zelník, Gibadulinová, Stanbridge, Závada, Kettmann, Pastorek: Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships. in Genomics 1996 (PubMed)
    Show all 5 references for ABIN2008118

  3. Human CA9 Protein expressed in Human Cells - ABIN2002077 : Swietach, Wigfield, Cobden, Supuran, Harris, Vaughan-Jones: Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths. in The Journal of biological chemistry 2008 (PubMed)
    Show all 5 references for ABIN2002077

  4. Human CA9 Protein expressed in HEK-293 Cells - ABIN2180677 : Yu, Price, Badger: A Mutant Isolated from the Cyanobacterium Synechococcus PCC7942 Is Unable to Adapt to Low Inorganic Carbon Conditions. in Plant physiology 2002 (PubMed)
    Show all 5 references for ABIN2180677

  5. Human CA9 Protein expressed in Escherichia coli (E. coli) - ABIN1046760 : Grabmaier, Vissers, De Weijert, Oosterwijk-Wakka, Van Bokhoven, Brakenhoff, Noessner, Mulders, Merkx, Figdor, Adema, Oosterwijk: Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250. in International journal of cancer. Journal international du cancer 2000 (PubMed)
    Show all 3 references for ABIN1046760

More Proteins for Carbonic Anhydrase IX (CA9) Interaction Partners

Mouse (Murine) Carbonic Anhydrase IX (CA9) interaction partners

  1. Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors.

  2. constitutive activation of the NF-kappaB (show NFKB1 Proteins) pathway in CAIX-depleted cells restored G-CSF (show CSF3 Proteins) secretion

  3. Downregulation of carbonic anhydrase IX promotes Col10a1 (show COL10A1 Proteins) expression in chondrocytes.

  4. CA IX may directly or indirectly play novel functions in brain tissue.

  5. Data show that CA9, GLUT1 (show SLC2A1 Proteins) and LOX (show LOX Proteins) mRNA levels were equally and strongly correlated to hypoxic extent in FaDudd, and the same profile was observed for CA9 and GLUT1 (show SLC2A1 Proteins), but not LOX (show LOX Proteins), in SCCVII tumors.

  6. a novel role for CA IX in the regulation of immunologic processes and digestion

  7. although CA IX-deficiency is not a tumor-promoting factor per se, it induces glandular atrophy in the body mucosa, a lesion which is considered to be a preneoplastic alteration in the stomach

  8. These results suggest that the loss of function of cytosolic CA II (show CA2 Proteins) in the stomach of Car2 (show CA2 Proteins)-/- mice leads to up-regulation of an extracellular CA, namely CA IX, which is expressed on the cell surface of the gastric epithelium.

  9. CA9 may regulate ion and pH homeostasis within the developing embryo.

  10. CA9 has chaperone-like functions and CA9 shed from tumors may play a direct role in stimulating an adaptive immune response

Human Carbonic Anhydrase IX (CA9) interaction partners

  1. Flow cytometrically sorted CA9+ population showed increased mRNA level of a Wnt (show WNT2 Proteins) signaling factor AXIN2 (show AXIN2 Proteins). In conclusion, these observations indicate that CA9 expression in normal crypt base cells has association with intestinal epithelial stemness

  2. We used cobalt chloride (CoCl2) as a hypoxia-mimetic agent and found that the expression of HIF-1a (show HIF1A Proteins) protein, CA IX mRNA and protein, is effectively upregulated, except for HIF-1a (show HIF1A Proteins) mRNA.

  3. We conclude that CA9/miR34 interplay shares in the hypoxic regulation of mammospheres and therefore, may play a relevant role in the hypoxic breast cancer stem cell niche.

  4. Knockdown of CAIX significantly reduced proliferation of cancer cells, suggesting that rapid efflux of lactate and H(+), as enhanced by CAIX, contributes to cancer cell survival under hypoxic conditions.

  5. Data indicate that carbonic anhydrase IX (CAIX) inhibition as a relevant therapeutic goal in breast cancer, targeting the migratory, invasive, and metastatic potential of this disease.

  6. Inhibition of CA9 expression or activity resulted in radiation sensitization of RCC (show XRCC1 Proteins) in a preclinical mouse model.

  7. Urinary CAIX has a high sensitivity and specificity for diagnosing urothelial bladder cancer.

  8. The intrinsic thermodynamic parameters of compound binding to CA IX helped to draw the compound structure to thermodynamics relationship.

  9. our study showed that the expression of CAIX in oral squamous cell carcinoma (OSCC) samples can predict the progression of OSCC and survival of OSCC patients in Taiwan

  10. we aimed to determine the effect of immunohistochemical staining of ezrin (show EZR Proteins), carbonic anhydrase IX (CA IX), and neuropilin-2 (show NRP2 Proteins) on the prognosis of patients diagnosed with metastatic RCC (show XRCC1 Proteins) who were treated with TKIs between January 2007 and June 2012.

Carbonic Anhydrase IX (CA9) Protein Profile

Protein Summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.

Gene names and symbols associated with Carbonic Anhydrase IX Proteins (CA9)

  • carbonic anhydrase IX (CA9)
  • carbonic anhydrase 9 (CAH9)
  • carbonic anhydrase 9 (Car9)
  • carbonic anhydrase IX (LOC100337777)
  • Ca9 protein
  • CAIX protein
  • MN protein
  • MN/CA9 protein

Protein level used designations for Carbonic Anhydrase IX Proteins (CA9)

carbonic anhydrase IX , carbonic anhydrase 9 , CA-IX , carbonate dehydratase IX , membrane antigen MN homolog , P54/58N , RCC-associated antigen G250 , RCC-associated protein G250 , carbonic dehydratase , membrane antigen MN , pMW1 , renal cell carcinoma-associated antigen G250

GENE ID SPECIES
473223 Pan troglodytes
511923 Bos taurus
5726457 Chlamydomonas reinhardtii
230099 Mus musculus
313495 Rattus norvegicus
768 Homo sapiens
611933 Canis lupus familiaris
100152792 Sus scrofa
770004 Gallus gallus
100337777 Oryctolagus cuniculus
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