Carbonic Anhydrase IX Proteins (CA9)

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Additionally we are shipping Carbonic Anhydrase IX Antibodies (274) and Carbonic Anhydrase IX Kits (43) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CA9 230099 Q8VHB5
Rat CA9 CA9 313495  
CA9 768 Q16790
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Top Carbonic Anhydrase IX Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag Human Carbonic Anhydrase IX (38-414), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Log in to see 2 to 3 Days
$385.00
Details
HOST_Human Cells Human Fc Tag 10 μg Log in to see 20 to 21 Days
$206.80
Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 20 to 21 Days
$206.80
Details
HOST_Human Cells Dog His tag 10 μg Log in to see 20 to 21 Days
$206.80
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 13 to 16 Days
$242.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_HEK-293 Cells Human His tag 10 μg Log in to see 2 to 3 Days
$267.75
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

CA9 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
,
Human , , , , ,
, , , , ,

Top referenced Carbonic Anhydrase IX Proteins

  1. Dog (Canine) CA9 Protein expressed in Human Cells - ABIN2008868 : Pastorek, Pastoreková, Callebaut, Mornon, Zelník, Opavský, Zatovicová, Liao, Portetelle, Stanbridge: Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment. in Oncogene 1994 (PubMed)
    Show all 5 references for 2008868

  2. Mouse (Murine) CA9 Protein expressed in Human Cells - ABIN2008118 : Opavský, Pastoreková, Zelník, Gibadulinová, Stanbridge, Závada, Kettmann, Pastorek: Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships. in Genomics 1996 (PubMed)
    Show all 5 references for 2008118

  3. Human CA9 Protein expressed in Human Cells - ABIN2002077 : Swietach, Wigfield, Cobden, Supuran, Harris, Vaughan-Jones: Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths. in The Journal of biological chemistry 2008 (PubMed)
    Show all 5 references for 2002077

  4. Human CA9 Protein expressed in HEK-293 Cells - ABIN2180677 : Yu, Price, Badger: A Mutant Isolated from the Cyanobacterium Synechococcus PCC7942 Is Unable to Adapt to Low Inorganic Carbon Conditions. in Plant physiology 2002 (PubMed)
    Show all 5 references for 2180677

  5. Human CA9 Protein expressed in Escherichia coli (E. coli) - ABIN1046760 : Grabmaier, Vissers, De Weijert, Oosterwijk-Wakka, Van Bokhoven, Brakenhoff, Noessner, Mulders, Merkx, Figdor, Adema, Oosterwijk: Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250. in International journal of cancer. Journal international du cancer 2000 (PubMed)
    Show all 3 references for 1046760

More Proteins for Carbonic Anhydrase IX (CA9) Interaction Partners

Mouse (Murine) Carbonic Anhydrase IX (CA9) interaction partners

  1. Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors.

  2. constitutive activation of the NF-kappaB (show NFKB1 Proteins) pathway in CAIX-depleted cells restored G-CSF (show CSF3 Proteins) secretion

  3. Downregulation of carbonic anhydrase IX promotes Col10a1 (show COL10A1 Proteins) expression in chondrocytes.

  4. CA IX may directly or indirectly play novel functions in brain tissue.

  5. Data show that CA9, GLUT1 (show SLC2A1 Proteins) and LOX (show LOX Proteins) mRNA levels were equally and strongly correlated to hypoxic extent in FaDudd, and the same profile was observed for CA9 and GLUT1 (show SLC2A1 Proteins), but not LOX (show LOX Proteins), in SCCVII tumors.

  6. a novel role for CA IX in the regulation of immunologic processes and digestion

  7. although CA IX-deficiency is not a tumor-promoting factor per se, it induces glandular atrophy in the body mucosa, a lesion which is considered to be a preneoplastic alteration in the stomach

  8. These results suggest that the loss of function of cytosolic CA II (show CA2 Proteins) in the stomach of Car2 (show CA2 Proteins)-/- mice leads to up-regulation of an extracellular CA, namely CA IX, which is expressed on the cell surface of the gastric epithelium.

  9. CA9 may regulate ion and pH homeostasis within the developing embryo.

  10. CA9 has chaperone-like functions and CA9 shed from tumors may play a direct role in stimulating an adaptive immune response

Human Carbonic Anhydrase IX (CA9) interaction partners

  1. Data suggest that CAIX (carbonic anhydrase IX) is a novel downstream mediator of asTF (alternatively spliced tissue factor (show F3 Proteins)) in pancreatic ductal adenocarcinoma, particularly under hypoxic conditions that model late-stage tumor microenvironment; tumor hypoxia appears to lead to up-regulation of CAIX expression (or 'activation'), which is more pronounced in tumor cells overexpressing asTF.

  2. Our findings suggest that LCN2 (show LCN2 Proteins) suppresses tumour metastasis by targeting the transcriptional and post-transcriptional regulation of CAIX in oral squamous cell carcinoma

  3. CA II (show CA2 Proteins) and CA XII, but not CA VII (show CA7 Proteins) or CA IX, could be useful in predicting survival in colorectal carcinomas

  4. The findings suggest that CA9, and particularly its carbonic anhydrase activity, promotes the tumorigenicity of adult T-cell leukemia/lymphoma-derived cells and may be involved in malignant development of lymphoma-type adult T-cell leukemia/lymphoma.

  5. We demonstrated that the expression levels of glycolysis-related proteins glucose transporter 1 (show SLC2A1 Proteins), hexokinase II, carbonic anhydrase IX, and monocarbonylate transporter 4 differ between thyroid cancer subtypes and are correlated with poorer prognosis

  6. CAIX and PTEN had prognostic importance for metastatic renal cell carcinoma (show MOK Proteins) patients receiving first-line VEGFR (show KDR Proteins) TKI. Future validation and mechanistic studies are required.

  7. combined HIF1alpha (show HIF1A Proteins) and CAIX protein expression may serve as an unfavorable prognostic indicator particularly in patients treated with cyclophosphamide-based chemotherapy or radiotherapy as well as those with basal phenotype of breast cancer

  8. CA9 may have a role in castration-resistant prostate cancer progression

  9. The diagnostic accuracy of CA9 expression for clear cell renal cell carcinoma (show MOK Proteins) was 100%.

  10. High expression of CA IX was associated with pancreatic cancer.

Carbonic Anhydrase IX (CA9) Protein Profile

Protein Summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.

Gene names and symbols associated with Carbonic Anhydrase IX Proteins (CA9)

  • carbonic anhydrase IX (CA9)
  • carbonic anhydrase 9 (CAH9)
  • carbonic anhydrase 9 (Car9)
  • carbonic anhydrase IX (LOC100337777)
  • Ca9 protein
  • CAIX protein
  • MN protein
  • MN/CA9 protein

Protein level used designations for Carbonic Anhydrase IX Proteins (CA9)

carbonic anhydrase IX , carbonic anhydrase 9 , CA-IX , carbonate dehydratase IX , membrane antigen MN homolog , P54/58N , RCC-associated antigen G250 , RCC-associated protein G250 , carbonic dehydratase , membrane antigen MN , pMW1 , renal cell carcinoma-associated antigen G250

GENE ID SPECIES
473223 Pan troglodytes
511923 Bos taurus
5726457 Chlamydomonas reinhardtii
230099 Mus musculus
313495 Rattus norvegicus
768 Homo sapiens
611933 Canis lupus familiaris
100152792 Sus scrofa
770004 Gallus gallus
100337777 Oryctolagus cuniculus
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