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The protein encoded by CA8 is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Additionally we are shipping Carbonic Anhydrase VIII Proteins (14) and Carbonic Anhydrase VIII Kits (2) and many more products for this protein.
Showing 10 out of 60 products:
Human Polyclonal CA8 Primary Antibody for IHC - ABIN965733
Skaggs, Bergenhem, Venta, Tashian: The deduced amino acid sequence of human carbonic anhydrase-related protein (CARP) is 98% identical to the mouse homologue. in Gene 1993
Show all 5 Pubmed References
Human Polyclonal CA8 Primary Antibody for ICC, WB - ABIN261487
Hirota, Ando, Hamada, Mikoshiba: Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1. in The Biochemical journal 2003
Show all 2 Pubmed References
Car8 regulates inflammatory pain by inhibiting the ITPR1 (show ITPR1 Antibodies)-cytosolic free calcium pathway.
Results indicate a widespread disruption in cerebellar circuitry hampering proper neuronal communication in CAR8 mutant mice
CA8 overexpression desensitizes neuronal cells to STS (show STS Antibodies) induced apoptotic stress and increases cell migration and invasion ability in neuronal cells.
The datum of this study provide evidence that the CAVIII protein, which is highly conserved in vertebrates, is selectively expressed within neural circuits, and may be important for modulating retinal neurotransmission.
Results describe the tissue distribution of carbonic anhydrase-related proteins VIII (show COX8A Antibodies), X, and XI and their developmental expression in the murine embryonic brain.
CAR8 plays a central role in motor control; data indicate that the waddles mouse is a Car8 null mutant.
Car8 plays a critical role in synaptogenesis and/or maintenance of proper synaptic morphology and function in the cerebellum
We provide evidence that the CA8 gene product is indispensable in early embryonic development in zebra fi sh, particularly in the brain and eye.
we observed increased expression of CA8 in more aggressive types of human osteosarcoma (OS) cells and found that CA8 expression is correlated with disease stages, such that more intense expression occurs in the disease late stage
Overexpression of CA8 in MERRF cybrids significantly decreases cell death.
This report expands the neurological and radiological phenotype associated with CA8 mutations.
review article describes the previous data on CARP VIII (show COX8A Antibodies), including its structure, role in neurodegeneration and cancer; and bioinformatic and expression analyses.
Crystal structure of human carbonic anhydrase-related protein VIII (show COX8A Antibodies) reveals the basis for catalytic silencing
Overexpression of Carbonic anhydrase-related protein VIII (show COX8A Antibodies) promotes colon cancer cell growth
The results suggest that the variations of CA8 and CA10 (show CA10 Antibodies) loci may be important determinants of osteoporosis in Japanese women.
Consanguineous Iraqi family in which affected siblings had mild mental retardation and congenital ataxia characterized by quadrupedal gait. The mutation S100P (show S100P Antibodies) is associated with proteasome-mediated degradation, and presumably represents a null mutation.
The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form.
carbonic anhydrase 8
, CA-RP VIII
, carbonic anhydrase VIII
, carbonic anhydrase-like sequence 1
, carbonic anhydrase-related protein
, CARP VIII
, CA-related protein
, carbonate dehydratase
, carbonic anhydrase-like sequence