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Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. Additionally we are shipping CBR1 Proteins (33) and CBR1 Kits (5) and many more products for this protein.
Showing 10 out of 119 products:
Human Monoclonal CBR1 Primary Antibody for ELISA, WB - ABIN560201
Bains, Karkling, Grigliatti, Reid, Riggs: Two nonsynonymous single nucleotide polymorphisms of human carbonyl reductase 1 demonstrate reduced in vitro metabolism of daunorubicin and doxorubicin. in Drug metabolism and disposition: the biological fate of chemicals 2009
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Cow (Bovine) Polyclonal CBR1 Primary Antibody for WB - ABIN2782365
Cheon, Shim, Kim, Hara, Lubec: Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: Challenging the gene dosage effect hypothesis (Part IV). in Amino acids 2003
Show all 2 references for 2782365
Cow (Bovine) Polyclonal CBR1 Primary Antibody for IHC, WB - ABIN2782364
Lim, Shin, Jo, Jyothi, Nguyen, Choi, Kim, Park, Eun, Yoon, Ha, Kim: Carbonyl reductase 1 is an essential regulator of skeletal muscle differentiation and regeneration. in The international journal of biochemistry & cell biology 2013
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Human Polyclonal CBR1 Primary Antibody for IHC, ELISA - ABIN184784
Balcz, Kirchner, Cairns, Fountoulakis, Lubec: Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down syndrome and Alzheimer's disease. in Journal of neural transmission. Supplementum 2001
Data suggest that fatty acids and acyl-CoAs bind competitively with respect to substrate binding to carbonyl reductase 1 (CBR1), an enzyme involved in first-pass drug metabolism in intestinal mucosa; inhibition of CBR1 by these products of digestion may lead to food-drug interactions.
AKR1C3 (show AKR1C3 Antibodies) is the primary enzyme and CBR1 is a minor enzyme responsible for warfarin reduction in human liver cytosol.
These results suggest that CR1 (show CR1 Antibodies) induces apoptosis by activating the caspase (show CASP3 Antibodies) pathway via binding to TNFR1 (show TNFRSF1A Antibodies).
Critical insights into the substrate selectivity of hCBR1 and the interaction between hCBR1 and glutathione.
Up-Regulation of Carbonyl Reductase 1 Renders Development of Doxorubicin Resistance in Human Gastrointestinal Cancers
CBR1 decreases promoted tumor proliferation and growth as well as invasion and metastasis; CBR1 has potential to become a new candidate for molecular targeting therapy.
Inhibition of CBR1 may increase the efficacy of daunorubicin in cancer tissue.
Protein products of AKR1C1 (show DDH Antibodies), AKR1C2 (show AKR1C2 Antibodies), AKR7A3 (show AKR7A3 Antibodies), CYP3A4 (show CYP3A4 Antibodies), and carbonyl reductase (CBR1) were found in tumors and those of AKR1C1 (show DDH Antibodies), AKR7A3 (show AKR7A3 Antibodies), and CBR1 correlated with their transcript levels.
we suggest that PEP-1-CBR1 protein may be a therapeutic agent for the treatment of ischemic injuries as well as oxidative-stress-induced (show SQSTM1 Antibodies) cell damage and death.
The stimulatory effect of cortisol on CBR1 expression may partly explain the concurrent increases of cortisol and prostaglandin PGF2alpha in human amnion tissue prior to the onset of labor
two Cys (show DNAJC5 Antibodies) residues, Cys (show DNAJC5 Antibodies) 149 and Cys (show DNAJC5 Antibodies) 226, are involved in the enzyme activity; Cys (show DNAJC5 Antibodies) 226 is involved in binding of the cofactor NADPH (show NQO1 Antibodies).
results indicate that the disturbances in 9-KPR activity in bovine retained placenta exist but their reasons still require further experiments
CBR1 plays a critical role in controlling redox balance and detoxifying lipid peroxidation during muscle differentiation and regeneration.
CBR1 attenuates apoptosis and promotes cell survival in pancreatic beta-cell lines under glucotoxic and glucolipotoxic conditions via reducing ROS (show ROS1 Antibodies) generation
Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q.
carbonyl reductase [NADPH] 1
, carbonyl reductase 1
, 15-hydroxyprostaglandin dehydrogenase
, 20-beta-hydroxysteroid dehydrogenase
, NADPH-dependent carbonyl reductase 1
, prostaglandin 9-ketoreductase
, prostaglandin-E(2) 9-reductase
, carbonyl reductase
, carbonyl reductase (NADPH) 1
, short chain dehydrogenase/reductase family 21C, member 1
, 20-hydroxysteroid dehydrogenase
, prostaglandin E(2) 9-keto reductase
, NADPH:secondary-alcohol oxidoreductase
, Carbonyl reductase [NADPH] 1 (NADPH-dependent carbonyl reductase 1)
, Cbr 1