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Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. Additionally we are shipping CBR1 Antibodies (121) and CBR1 Kits (5) and many more products for this protein.
Showing 10 out of 33 products:
Human CBR1 Protein expressed in Wheat germ - ABIN1348184
Atsriku, Hoffmann, Moghaddam, Kumar, Surapaneni: In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism. in Xenobiotica; the fate of foreign compounds in biological systems 2015
Data suggest that fatty acids and acyl-CoAs bind competitively with respect to substrate binding to carbonyl reductase 1 (CBR1), an enzyme involved in first-pass drug metabolism in intestinal mucosa; inhibition of CBR1 by these products of digestion may lead to food-drug interactions.
AKR1C3 (show AKR1C3 Proteins) is the primary enzyme and CBR1 is a minor enzyme responsible for warfarin reduction in human liver cytosol.
These results suggest that CR1 induces apoptosis by activating the caspase (show CASP3 Proteins) pathway via binding to TNFR1 (show TNFRSF1A Proteins).
Critical insights into the substrate selectivity of hCBR1 and the interaction between hCBR1 and glutathione.
Up-Regulation of Carbonyl Reductase 1 Renders Development of Doxorubicin Resistance in Human Gastrointestinal Cancers
CBR1 decreases promoted tumor proliferation and growth as well as invasion and metastasis; CBR1 has potential to become a new candidate for molecular targeting therapy.
Inhibition of CBR1 may increase the efficacy of daunorubicin in cancer tissue.
Protein products of AKR1C1 (show DDH Proteins), AKR1C2 (show AKR1C2 Proteins), AKR7A3 (show AKR7A3 Proteins), CYP3A4 (show CYP3A4 Proteins), and carbonyl reductase (CBR1) were found in tumors and those of AKR1C1 (show DDH Proteins), AKR7A3 (show AKR7A3 Proteins), and CBR1 correlated with their transcript levels.
we suggest that PEP-1-CBR1 protein may be a therapeutic agent for the treatment of ischemic injuries as well as oxidative-stress-induced (show SQSTM1 Proteins) cell damage and death.
The stimulatory effect of cortisol on CBR1 expression may partly explain the concurrent increases of cortisol and prostaglandin PGF2alpha in human amnion tissue prior to the onset of labor
two Cys residues, Cys 149 and Cys 226, are involved in the enzyme activity; Cys 226 is involved in binding of the cofactor NADPH.
results indicate that the disturbances in 9-KPR activity in bovine retained placenta exist but their reasons still require further experiments
CBR1 plays a critical role in controlling redox balance and detoxifying lipid peroxidation during muscle differentiation and regeneration.
CBR1 attenuates apoptosis and promotes cell survival in pancreatic beta-cell lines under glucotoxic and glucolipotoxic conditions via reducing ROS (show ROS1 Proteins) generation
Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q.
carbonyl reductase [NADPH] 1
, carbonyl reductase 1
, 15-hydroxyprostaglandin dehydrogenase
, 20-beta-hydroxysteroid dehydrogenase
, NADPH-dependent carbonyl reductase 1
, prostaglandin 9-ketoreductase
, prostaglandin-E(2) 9-reductase
, carbonyl reductase
, carbonyl reductase (NADPH) 1
, short chain dehydrogenase/reductase family 21C, member 1
, 20-hydroxysteroid dehydrogenase
, prostaglandin E(2) 9-keto reductase
, NADPH:secondary-alcohol oxidoreductase
, Carbonyl reductase [NADPH] 1 (NADPH-dependent carbonyl reductase 1)
, Cbr 1