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CMBL (EC 188.8.131.52) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. Additionally we are shipping CMBL Proteins (9) and many more products for this protein.
Showing 9 out of 12 products:
Human Monoclonal CMBL Primary Antibody for EIA, WB - ABIN1449403
Ishizuka, Fujimori, Kato, Noji-Sakikawa, Saito, Yoshigae, Kubota, Kurihara, Izumi, Ikeda, Okazaki: Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine. in The Journal of biological chemistry 2010
Show all 2 references for ABIN1449403
By comparing the enzyme kinetics and chemical inhibition properties between the recombinant protein and tissue preparations, CMBL was shown to be the primary olmesartan medoxomil bioactivating enzyme in the liver and intestine.
CMBL (EC 184.108.40.206) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010
, carboxymethylenebutenolidase-like (Pseudomonas)
, liver regeneration-related protein LRRG072