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CMBL (EC 18.104.22.168) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. Additionally we are shipping CMBL Antibodies (32) and many more products for this protein.
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Human CMBL Protein expressed in Escherichia coli (E. coli) - ABIN1098348
Ravandi, Issa, Garcia-Manero, OBrien, Pierce, Shan, Borthakur, Verstovsek, Faderl, Cortes, Kantarjian: Superior outcome with hypomethylating therapy in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome and chromosome 5 and 7 abnormalities. in Cancer 2009
Show all 2 references for ABIN1098348
Human CMBL Protein expressed in Escherichia coli (E. coli) - ABIN2004265
Ishizuka, Fujimori, Kato, Noji-Sakikawa, Saito, Yoshigae, Kubota, Kurihara, Izumi, Ikeda, Okazaki: Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine. in The Journal of biological chemistry 2010
By comparing the enzyme kinetics and chemical inhibition properties between the recombinant protein and tissue preparations, CMBL was shown to be the primary olmesartan medoxomil bioactivating enzyme in the liver and intestine.
CMBL (EC 22.214.171.124) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010
, carboxymethylenebutenolidase-like (Pseudomonas)
, liver regeneration-related protein LRRG072