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anti-Carboxypeptidase E (CPE) Antibodies

CPE encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Additionally we are shipping Carboxypeptidase E Proteins (26) and Carboxypeptidase E Kits (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CPE 1363 P16870
CPE 12876 Q00493
CPE 25669 P15087
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Top anti-Carboxypeptidase E Antibodies at antibodies-online.com

Showing 10 out of 80 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-CPE Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: MCF7 cell lysate Immunohistochemistry with Brain, cerebellum tissue at an antibody concentration of 5µg/ml using anti-CPE antibody (ARP58445_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of CPE antibody (C-term) (ABIN392011) in mouse cerebellum tissue lysates (35 µg/lane). CPE (arrow) was detected using the purified polyclonal antibody. Western blot analysis of CPE antibody (C-term) (ABIN392011) in Hela cell line lysates (35 µg/lane). CPE (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of Carboxypeptidase E on rat brain lysate (First Panel). Lane 1: 1:2500, lane 2: 1:5000, lane 3: 1:10000 dilution of Carboxypeptidase E, Immunofluorescent staining of SH-SY5Y cells (Second Panel). Cells were seeded in a collagen coated 384 well imaging plate at ~ 8,000 cells per well. After overnight incubation, cells were stained using the Triton X100 fix/perm protocol and the anti-Carboxypeptidase E antibody. The second step reagent was Alexa Fluor® 488 goat anti mouse Ig (Invitrogen). The image was taken on a Pathway 855 or 435 imager using a 20x objective. This antibody also stained SK-N-SH and C6 cells using both the Triton X100 and methanol fix/perm protocols. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from RAW264.7/NIH-3T3 cells, using CPE Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image Carboxypeptidase E antibody [N2C2], Internal detects Carboxypeptidase E protein at nucleus on human breast cancer by immunohistochemical analysis. Sample: Paraffin-embedded breast cancer. Carboxypeptidase E antibody [N2C2], Internal , dilution: 1:500. WB Image Western Blot analysis of CPE expression in transfected 293T cell line by CPE polyclonal antibody. A: Non-transfected lysate. B: CPE transfected lysate. 12% SDS PAGE antibody diluted at 1:500 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-CPE antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN958305 concentration 5 ug/ml. 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of Carboxypeptidase E expression in NIH3T3 (A), PC12 (B) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated ICC, IHC (p), IP, WB Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human liver carcinoma labeled with Rabbit Anti CPE/Carboxypeptidase H Polyclonal Antibody, Unconjugated (ABIN1387591) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Pancreas, Islet: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 8 to 10 Days
$451.00
Details

CPE Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Carboxypeptidase E Antibodies

  1. Human Monoclonal CPE Primary Antibody for IF, IP - ABIN968159 : Cool, Normant, Shen, Chen, Pannell, Zhang, Loh: Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice. in Cell 1997 (PubMed)
    Show all 4 references for ABIN968159

  2. Human Polyclonal CPE Primary Antibody for ELISA, WB - ABIN1534734 : Utsunomiya, Ohagi, Sanke, Tatsuta, Hanabusa, Nanjo: Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity. in Diabetologia 1998 (PubMed)
    Show all 2 references for ABIN1534734

  3. Human Polyclonal CPE Primary Antibody for WB - ABIN392011 : Oiso, Takeda, Futagawa, Miura, Kuchiiwa, Nishida, Ikeda, Kariyazono, Watanabe, Yamada: Contactin-associated protein (Caspr) 2 interacts with carboxypeptidase E in the CNS. in Journal of neurochemistry 2009 (PubMed)

  4. Chicken Polyclonal CPE Primary Antibody for IHC, WB - ABIN2787685 : Wang, Zhang, Yang, Zhu, Wang, Chen, Cao, Huang, Ma, Jia: Association of human carboxypeptidase E exon5 gene polymorphisms with angiographical characteristics of coronary atherosclerosis in a Chinese population. in Acta pharmacologica Sinica 2008 (PubMed)

More Antibodies against Carboxypeptidase E Interaction Partners

Human Carboxypeptidase E (CPE) interaction partners

  1. Down-expression of liver carboxypeptidase E may reduce the secretion of serum cholecystokinin (show CCK Antibodies) and contribute to the formation of cholesterol gallstone.

  2. Downregulation of CPE regulates cell proliferation and chemosensitivity in pancreatic cancer.

  3. Disruption of insulin receptor (IR (show INSR Antibodies)) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE) by inhibition of the eukaryotic translation initiation factor (show EIF2A Antibodies) Eif4g1 (show EIF4G1 Antibodies).

  4. Upregulation of CPE promotes cell proliferation and tumorigenicity in colorectal cancer.

  5. Data suggest that splice variant of carboxypeptidase E (CPE-DeltaN) that CPE-DeltaN expression might be a potential prognostic marker for colorectal cancer patients.

  6. CPE is essential in the process and targeting of neuropeptides and neurotrophins, its participation in the pathological progression of Alzheimer's disease may be suggested

  7. CPE forms a complex, probably through sequences located at its N-terminal domain, with Wnt3a (show WNT3A Antibodies) and the extracellular cysteine rich domain of Fz1 (show FZD4 Antibodies).

  8. Neither high glucose nor insulin (show INS Antibodies) (with low glucose) regulates beta-cell CPE (but either up-regulates CPD (show CPD Antibodies)).

  9. an N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers

  10. CPE may play a role in promoting tumor growth and invasion.

Mouse (Murine) Carboxypeptidase E (CPE) interaction partners

  1. we show by RNA silencing that CPE and SgIII (show SCG3 Antibodies) play a synergistic role in the trafficking of POMC (show POMC Antibodies) to granules of the regulated secretory pathway in AtT20 cells

  2. An anti-inflammatory role of CPE in the intestine by influencing local cytokine levels and thus regulating the migration of myeloid immune cells into the mucosa.

  3. This study shown that NF-alpha1-mediated upregulation of hippocampal FGF2 (show FGF2 Antibodies) and neurogenesis prevents an onset of chronic stress-induced depressive-like behavior

  4. The neuroprotective effect of CPE-DeltaN against neuronal glutamate (show GRIN1 Antibodies) neurotoxicity was mediated by secreted FGF2 (show FGF2 Antibodies).

  5. Carboxypeptidase E is an important modulator of RANKL (show TNFSF11 Antibodies)-induced osteoclast differentiation.

  6. Report the effects of ovalbumin (show OVA Antibodies) sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice.

  7. Disruption of insulin receptor (IR (show INSR Antibodies)) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE) by inhibition of the eukaryotic translation initiation factor (show EIF2A Antibodies) Eif4g1 (show EIF4G1 Antibodies).

  8. This study has identified CPE as a new neurotrophic factor (show NTF3 Antibodies) that can protect neurons against degeneration.

  9. Data suggests that CPE plays critical role in neuroprotection/allostasis in hippocampal neurons during mild chronic stress; up-regulation of CPE and BCL2 (B cell leukemia/lymphoma 2) expression is possibly mediated by glucocorticoids.

  10. There are multiple mechanisms for sorting proglucagon (show GCG Antibodies) to the regulated secretory pathway, including a role for carboxypeptidase E in pancreatic alpha cells, initial cleavage at K70R71 and multiple sorting signals.

Carboxypeptidase E (CPE) Antigen Profile

Protein Summary

This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.

Gene names and symbols associated with CPE

  • carboxypeptidase E (CPE) antibody
  • carboxypeptidase E (cpe) antibody
  • carboxypeptidase E (Cpe) antibody
  • CARBE antibody
  • CPE antibody
  • Cph antibody
  • Cph-1 antibody
  • Cph1 antibody
  • fat antibody
  • R74677 antibody
  • si:ch211-198g9.2 antibody
  • zgc:85981 antibody

Protein level used designations for CPE

carboxypeptidase E , carboxypeptidase E preproprotein , carboxypeptidase E-like , CPH , carboxypeptidase H , cobalt-stimulated chromaffin granule carboxypeptidase , enkephalin convertase , insulin granule-associated carboxypeptidase , prohormone-processing carboxypeptidase

GENE ID SPECIES
443028 Ovis aries
475492 Canis lupus familiaris
708881 Macaca mulatta
100127580 Xenopus (Silurana) tropicalis
100397838 Callithrix jacchus
100458397 Pongo abelii
1363 Homo sapiens
280753 Bos taurus
12876 Mus musculus
25669 Rattus norvegicus
407979 Danio rerio
100158368 Xenopus laevis
422424 Gallus gallus
100037304 Sus scrofa
461592 Pan troglodytes
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