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CEACAM1 encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily.
Results report that CEACAM1 was uniquely expressed at high levels in both human neoplastic mast cells (mastocytosis) and medullary thyroid carcinoma cell (MTC (show MT1A ELISA Kits)) lines, and suggest that the dominantly interacting proteins SHP1 (show PTPN6 ELISA Kits) or SFK determine whether CEACAM1-L displays a positive or negative role in tumor cells. .
SASH1 acts through NOTCH1 (show NOTCH1 ELISA Kits) and its inhibitor DLK1 (show DLK1 ELISA Kits) in a three-dimensional model of lumenogenesis involving CEACAM1.
CEACAM1 also inhibits viral spread in ex vivo human decidua organ culture.
In enterocytic C2BBe1 cells, Candida albicans caused a transient tyrosine phosphorylation of CEACAM1 and induced higher expression of membrane-bound CEACAM1 and soluble CEACAM6.
REVIEW: summarizes the vascular effects of CEACAM1 and focuses on its role in vascular morphogenesis and endothelial barrier regulation
We also found that MMP12 (show MMP12 ELISA Kits) facilitated type I collagen induced platelet aggregation, adhesion and alpha granule secretion. Similarly, one short peptide, WYKG, facilitated type I collagen induced platelet alpha granule secretion. We conclude that platelet express MMP12 (show MMP12 ELISA Kits) may facilitate platelet activation through shedding of CEACAM1.
We demonstrate that recombinant Neisseria Opa proteins reconstituted into liposomes retain the ability to recognize and interact with CEACAM1 and 3 in vitro but do not maintain receptor specificity compared to that of Opa proteins natively expressed by Neisseria gonorrhoeae.
use NMR cross-correlation measurements to examine the effect of glycosylation on CEACAM1-IgV dimerization and use residual dipolar coupling (RDC) measurements to characterize the solution structure of the non-glycosylated form.
miRNA-342 Regulates CEACAM1-induced Lumen Formation in a Three-dimensional Model of Mammary Gland Morphogenesis.
The diffuse and cytoplasmic expression of CD66a may involve the early stage of the hepatocellular carcinoma , and the loss of CD66a expression indicates tumor progression.
our data show that human and bovine CEACAM1 can both inhibit NK-cell cytotoxicity although they differ in their intracellular signaling motifs
Data from cultured aortic endothelial cells suggest that CEACAM1 is involved in regulation of vascular endothelial cell reactions to oxidative stress/lipid peroxidation and in regulation of nitric oxide production in large vessels such as aorta.
This data represents the first report of a functional link between CEACAM1 and the VEGFR2 (show KDR ELISA Kits)/Akt (show AKT1 ELISA Kits)/eNOS (show NOS3 ELISA Kits)-mediated vascular permeability pathway.
CEACAM1 has two alleles and serves as a pathogen receptor in cattle.
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.
, antigen CD66
, carcinoembryonic antigen-related cell adhesion molecule 1
, CEA-related cell adhesion molecule 1
, carcinoembryonic antigen-related cell adhesion molecule 8