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Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Additionally we are shipping TNNC1 Antibodies (66) and TNNC1 Kits (8) and many more products for this protein.
Showing 10 out of 14 products:
Human TNNC1 Protein expressed in Escherichia coli (E. coli) - ABIN667967
Hamm: Acute coronary syndromes. The diagnostic role of troponins. in Thrombosis research 2001
Show all 2 references for ABIN667967
Human TNNC1 Protein expressed in Escherichia coli (E. coli) - ABIN2003717
Kalaji, Albitar: Predictive value of cardiac troponin T and I in hemodialysis patients. in Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 2012
We used nuclear magnetic resonance and circular dichroism to solve the structure and characterize the backbone dynamics and stability of the regulatory domain of cTnC with the L29Q mutation.
conclusive evidence that TNNC1 is an uncommon but definitive HCM-susceptibility gene
Troponin C (TnC) and the N-terminal helix of Troponin I (TnI N-helix), which occurs in vivo during muscle contraction.
FAK (show PTK2 Proteins)/CREB (show CREB1 Proteins)/TNNC1 has a role in mediating the effect of stromal MFAP5 (show MFAP5 Proteins) on ovarian cancer metastatic potential
Mutations in cTnC have been associated with hypertrophic or dilated cardiomyopathy.[review]
Data suggest that mutation A162H in switch region of troponin I induces transitory curved conformation and promotes contraction of troponin I bound to regulatory domain of troponin C; this is countered by residue E164 to ensure proper relaxation.
in vitro characterisation of six cardiac Troponin C mutations causing hypertrophic and dilated cardiomyopathies (Review)
The conformational dynamics of N-terminal lobe of TnC (show TNC Proteins) plays an important role in the regulation of cardiac muscle contraction.
Data indicate that domain positioning impacts the effective concentration of cardiac isoform of troponin I (cTnI) presented to cardiac troponin C (cTnC).
Toponin I, T, and C play crucial roles in muscle activity, connecting changes in intracellular Ca2 (show CA2 Proteins)+ concentration with generation of contraction. [review]
These results demonstrate that the L29Q mutation enhances the Ca(2+)-binding characteristics of cTnC and that when incorporated into cardiac myocytes, this mutant alters myocyte contractility.
Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle.
A region in cTnC associated with increased Ca(2+) sensitivity in skinned fibers was identified, an the F27W reporter mutation affected Ca(2+) sensitivity, maximal force, and ATPase activation of some mutants.
Overexpression of sTnC (show TNNC2 Proteins) polypeptide in muscle cells is controlled by its rapid degradation.
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase\; TnT, which contains the binding site for tropomyosin\; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z.
cardiac troponin C
, slow twitch skeletal/cardiac muscle troponin C
, troponin C, slow skeletal and cardiac muscles
, troponin C1, slow
, troponin C, cardiac/slow skeletal
, Troponin C, slow skeletal and cardiac muscles