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The protein encoded by CPT2 is a nuclear protein which is transported to the mitochondrial inner membrane. Additionally we are shipping CPT2 Antibodies (115) and CPT2 Proteins (10) and many more products for this protein.
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Human CPT2 ELISA Kit for Sandwich ELISA - ABIN418118
Lehmann, Zierz: Normal protein content but abnormally inhibited enzyme activity in muscle carnitine palmitoyltransferase II deficiency. in Journal of the neurological sciences 2014
CPT2 is active inside the mitochondrial matrix to recover acyl-CoA (show GNPAT ELISA Kits) from a process generally known as the carnitine shuttle. This protein is expressed in a constitutive way in all cells and tissues.
CPT II deficiency induces an energy crisis of the fatty acid metabolic pathway.
The rs2229291 and rs1799821 variants in CPT II gene might be one of the predisposing factors of acute encephalitis.
The F352C CPT2 variant might be a genetic risk factor for sudden unexpected death in infancy
The data indicate that within the muscle form of CPT II deficiency, the various genotypes have only marginal influence on the clinical and biochemical phenotype.
The homozygous genotype (AA) of CPT2 variant V368I had significantly less blood carnitine in acute myocardial infarction patients.
Allelic and phenotypic heterogeneity in 49 Italian patients with the muscle form of CPT-II deficiency
CPT2 and CACT (show SLC25A20 ELISA Kits) are crucial for mitochondrial acylcarnitine formation and export to the extracellular fluids in mitochondrial fatty acid beta-oxidation disorders.
the thermolabile F352C CPT II variant, found only in Japanese, might be one of the predisposing factors to trigger the pathomechanism of acute encephalopathy in the Japanese population
A homozygous mutation (c.534_558del25bpinsT) of CPT2 in a case of neonatal CPT II deficiency associated with Dandy-Walker syndrome and sudden death at 13 days of life.
Mice acclimatized to thermoneutrality revealed that Cpt2A-null interscapular brown adipose tissue failed to induce the expression of thermogenic genes such as Ucp1 (show UCP1 ELISA Kits) and Pgc1a (show PPARGC1A ELISA Kits).
Consistent with the known requirement for CPT2 in fatty acid oxidation, macrophages lacking CPT2 were unable to achieve b-oxidation of fatty acids yet still seemed to fully polarize toward an M2 state after stimulation with IL-4 (show IL4 ELISA Kits) in vitro and in vivo.
Cpt2 transcripts decrease following fertilization to undetectable levels and are present again later at the morula stage
It was conclude that suppression of CPT (show DHDDS ELISA Kits) activity by positive energy balance appears to be specific for the liver in mid-lactating dairy cows.
The protein encoded by this gene is a nuclear protein which is transported to the mitochondrial inner membrane. Together with carnitine palmitoyltransferase I, the encoded protein oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders.
carnitine O-palmitoyltransferase 2, mitochondrial
, carnitine palmitoyltransferase II
, carnitine palmitoyltransferase 2
, carnitine O-palmitoyltransferase
, carnitine O-palmitoyltransferase 2, mitochondrial-like
, CPT II
, mitochondrial carnitine palmitoyltransferase II