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CRTAC1 encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. Additionally we are shipping Cartilage Acidic Protein 1 Antibodies (47) and Cartilage Acidic Protein 1 Kits (5) and many more products for this protein.
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CRTAC1 acquired an alternate last exon from the tail-to-tail oriented neighbouring gene in humans resulting in the glycosylated isoform CRTAC1-A which represents a new extracellular matrix molecule of articular cartilage.
in bone fracture patients, 12 proteins were related to bone/cartilage metabolism, including: TGF-beta induced protein IG-H(3), cartilage acidic protein 1, procollagen C proteinase enhancer protein (show PCOLCE Proteins) and TGF-beta (show TGFB1 Proteins) receptor III.
These data suggest that LOTUS functions as a potent endogenous antagonist for NgR1 (show NEUROG1 Proteins) when bound by all four known NgR1 (show NEUROG1 Proteins) ligands.
These findings suggest that the UA/EC region is a functional domain of LOTUS serving for an antagonistic action to NgR1 (show NEUROG1 Proteins).
found CRTAC1-B(LOTUS)is key molecule for lateral olfactory tract(LOT)formation; NgR1 (show NEUROG1 Proteins) is LOTUS-binding protein;LOTUS suppressed Nogo (show RTN4 Proteins)-NgR1 (show NEUROG1 Proteins) binding and Nogo (show RTN4 Proteins)-induced growth cone collapse;suggest endogenous antagonism of NgR1 (show NEUROG1 Proteins) by LOTUS crucial for LOT formation
This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants.
cartilage acidic protein 1
, cartilage acidic protein 1a
, acidic secreted protein in cartilage
, chondrocyte expressed protein 68 kDa CEP-68
, 68 kDa chondrocyte-expressed protein
, protein CRTAC1-B