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Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. Additionally we are shipping Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase Proteins (7) and Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase Kits (4) and many more products for this protein.
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Rat (Rattus) Polyclonal CILP Primary Antibody for ELISA, WB - ABIN185679
Seki, Kawaguchi, Chiba, Mikami, Kizawa, Oya, Mio, Mori, Miyamoto, Masuda, Tsunoda, Kamata, Kubo, Toyama, Kimura, Nakamura, Ikegawa: A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. in Nature genetics 2005
CILP is involved in the etiology of intervertebral disc degeneration among young adults.
The researchers found that the single nucleotide polymorphism (1184T/C) of the CILP gene is associated an increased risk of lumbar disc degeneration in male athletes.
CILP regulates TGF-beta (show TGFB1 Antibodies) signaling and that this regulation has a crucial role in the etiology and pathogenesis of LDD.
These observations, together with the finding that CILP protein binds and inhibits TGF-beta1 (show TGFB1 Antibodies), suggest that CILP and TGF-beta1 (show TGFB1 Antibodies) may form a functional feedback loop that controls chondrocyte metabolism.
SNP analysis suggested that the CILP gene is not a major risk factor for symptoms of lumbar disc disease in Finnish or Chinese populations.
the CILP gene 1184T/C polymorphism is a significant risk factor for lumbar disc degeneration occurrence in Japanese collegiate judo athletes
Overexpression of CILP in the nucleus pulposus cells promotes disc degeneration, indicating that CILP plays a direct role in the pathogenesis of lumbar disc disease.
Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins\; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease.
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
, ClpX caseinolytic protease X homolog
, cartilage intermediate layer protein 1-like
, cartilage intermediate layer protein 1
, cartilage intermediate layer protein 1 C1
, cartilage intermediate layer protein 1 C2
, cartilage intermediate-layer protein
, nucleotide pyrophosphohydrolase