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CBLL1 encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. Additionally we are shipping Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 Proteins (5) and Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 Kits (3) and many more products for this protein.
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Cow (Bovine) Polyclonal CBLL1 Primary Antibody for WB - ABIN2781231
Frame: Newest findings on the oldest oncogene; how activated src does it. in Journal of cell science 2004
Show all 2 Pubmed References
Results suggest that Hakai is an important regulator of cell proliferation and that Hakai may be an oncoprotein and a potential molecular target for cancer treatment.
E-cadherin (show CDH1 Antibodies) distribution and expression is altered in utricle epithelia with induction of apoptosis.
these observations suggest that the dimeric architecture of the HYB domain is essential for the phosphotyrosine-binding property of Hakai.
By lowering Hakai abundance, miR (show MLXIP Antibodies)-203 also reduces Hakai-regulated-cell division.
Hakai dimerization allows the formation of a phosphotyrosine-binding pocket that recognizes specific phosphorylated tyrosines and flanking acidic amino acids of Src (show SRC Antibodies) substrates, such as E-cadherin (show CDH1 Antibodies), cortactin (show CTTN Antibodies) and DOK1 (show DOK1 Antibodies).
Hakai mediates E-cadherin (show CDH1 Antibodies) ubiquitination and degradation triggered by Slit-Robo signaling during colorectal epithelial cell carcinogenesis.
Together, these data do not support a requirement for CBLL1 during flavivirus entry and rather suggest an essential role of the ubiquitin/proteasome pathway for flavivirus genome amplification.
Results suggest that Hakai is a novel corepressor of ERalpha (show ESR1 Antibodies) and may play a negative role in the development and progression of breast cancers.
This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant.
E3 ubiquitin-protein ligase Hakai
, Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
, E3 ubiquitin-protein ligase Hakai-like
, e3 ubiquitin-protein ligase Hakai-like
, E-cadherin binding protein E7
, c-Cbl-like protein 1
, casitas B-lineage lymphoma-transforming sequence-like protein 1
, Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1
, RING finger protein 188
, Casitas B-lineage lymphoma-like 1