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Caspase inhibitor. Additionally we are shipping CARD16 Antibodies (20) and many more products for this protein.
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Expression of NOX4 (show NOX4 Proteins)/p22(phox (show CYBA Proteins)) as well as ROS (show ROS1 Proteins) production is enhanced by IL-1beta (show IL1B Proteins). On the other hand, the use of NOX4 (show NOX4 Proteins) inhibitors decreased IL-1beta (show IL1B Proteins)-induced collagenase synthesis by chondrocytes.
Caspase-1 (show CASP1 Proteins)-mediated cell death is regulated, at least in part, by the balance of Rip2 and Cop; alterations of this balance may contribute to aberrant caspase-1 (show CASP1 Proteins)-mediated pathogenesis in Huntington's disease.
Cop inhibition of cell death, at least to a certain extent, results from its interference with the activation of caspase-1 (show CASP1 Proteins) and caspase-4 (show CASP4 Proteins).
Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
CARD only domain-containing protein 1
, CARD only protein
, caspase recruitment domain-containing protein 16
, caspase-1 dominant-negative inhibitor pseudo-ICE
, caspase-1 inhibitor COP
, pseudo interleukin-1 beta converting enzyme
, pseudo interleukin-1beta converting enzyme