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Caspase Recruitment Domain Family, Member 8 Proteins (CARD8)

The protein encoded by CARD8 belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). Additionally we are shipping CARD8 Antibodies (80) and CARD8 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CARD8 22900 Q9Y2G2
CARD8    
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Top CARD8 Proteins at antibodies-online.com

Showing 3 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$3,191.83
Details

CARD8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Pongo abelii

More Proteins for Caspase Recruitment Domain Family, Member 8 (CARD8) Interaction Partners

Human Caspase Recruitment Domain Family, Member 8 (CARD8) interaction partners

  1. In patients with ileal, stenotic or fistulizing Crohn's disease, the mutant-type CARD8 rs2043211 polymorphism may generate a potentially protective effect. (Meta-analysis)

  2. There is evidence for association of gout with functional variants in CARD8, IL1B (show IL1B Proteins) and CD14 (show NDUFA2 Proteins).

  3. The polymorphism of rs2043211 in CARD8 may be a relevant host susceptibility factor for the development of preeclampsia in the Chinese Han population.

  4. A novel association between CARD8 and increased risk of surgical recurrence in Crohn's disease was observed and CARD8 could be a new marker for risk stratification and prevention of recurrent surgery.

  5. Patients carrying genotype TT of CARD8 rs2043211 polymorphism had higher triglycerides levels compared to those carrying the AA genotype.

  6. CARD8 might not play a role in the pathogenesis of Tourette syndrome in Chinese Han population

  7. Data indicate 3 variants in 3 novel genes myc target 1 protein (MYCT1), caspase recruitment domain family member 8 (CARD8) and zinc finger protein 543 (ZNF543 (show ZNF543 Proteins)), associated with familial IgA nephropathy (IgAN).

  8. we show that CARD8 plays a role as a negative regulator of NLRP3 (show NLRP3 Proteins) inflammasome through its binding with NLRP3 (show NLRP3 Proteins)

  9. levels of inflammasome-produced cytokines as a measure of inflammasome activation in healthy individuals carrying Q705K polymorphism in the NLRP3 (show NLRP3 Proteins) gene combined with C10X in the CARD8 gene

  10. ANRIL may increase the risk of ischemic stroke through regulation of the CARD8 pathway

CARD8 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.

Gene names and symbols associated with CARD8

  • caspase recruitment domain family, member 8 (CARD8)
  • CARD8 protein
  • CARDINAL protein
  • DACAR protein
  • DAKAR protein
  • NDPP protein
  • NDPP1 protein
  • TUCAN protein

Protein level used designations for CARD8

caspase recruitment domain family, member 8 , CARD inhibitor of NF-kappaB-activating ligands , apoptotic protein NDPP1 , caspase recruitment domain-containing protein 8 , tumor up-regulated CARD-containing antagonist of CASP9 , tumor up-regulated CARD-containing antagonist of caspase nine

GENE ID SPECIES
456176 Pan troglodytes
718594 Macaca mulatta
22900 Homo sapiens
100172562 Pongo abelii
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