You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Catechol-O-Methyltransferase (COMT) Antibodies

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. Additionally we are shipping COMT Kits (37) and COMT Proteins (26) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
COMT 1312 P21964
COMT 12846 O88587
COMT 24267 P22734
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-COMT Antibodies at antibodies-online.com

Showing 10 out of 180 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-COMT Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Stomach 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB Staining of human testis lysate (35µg protein in RIPA buffer) with A) EB07357 (0.03µg/ml) and B) ABIN185328 (1µg/ml). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Goat Un-conjugated ELISA, WB Staining of human testis lysate (35µg protein in RIPA buffer) with ABIN185328 (0.2µg/ml). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Dog Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Mouse Mouse Un-conjugated BI, IF, WB Western blot analysis of COMT on a rat pituitary lysate. Lane 1: 1:10,000, lane 2: 1:20,000, lane 3: 1:40,000 dilution of the anti- COMT antibody. Immunofluorescence staining of rat cortical neurons. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Mouse Un-conjugated WB COMT Antibody (N-term)(Ascites) (ABIN1882224) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the COMT antibody detected the COMT protein (arrow). 0.1 mL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated WB Western Blot analysis of COMT expression in transfected 293T cell line by COMT monoclonal antibody (M01), clone 1G4-1A1. Lane 1: COMT transfected lysate(24.4 KDa). Lane 2: Non-transfected lysate. COMT monoclonal antibody (M01), clone 1G4-1A1 Western Blot analysis of COMT expression in A-431. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated WB COMT MaxPab polyclonal antibody. Western Blot analysis of COMT expression in human placenta. Western Blot analysis of COMT expression in transfected 293T cell line by COMT MaxPab polyclonal antibody.Lane 1: COMT transfected lysate(24.31 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-COMT antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: A375 Cell Lysate Lane 3: PANC Cell Lysate Anti-COMT antibody, IHC(P) IHC(P): Human Lung Cancer Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details

COMT Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
, , ,
,
, , , , , , , , , , , , , ,
Mouse (Murine) , , , ,
, ,
,
, , , , , , , , , , ,
Rat (Rattus) , , , ,
, ,
,
, , , , , , , , , , ,

Top referenced anti-COMT Antibodies

  1. Human Polyclonal COMT Primary Antibody for ELISA, WB - ABIN185328 : Tunbridge, Harrison, Weinberger: Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. in Biological psychiatry 2006 (PubMed)
    Show all 5 references for ABIN185328

  2. Human Monoclonal COMT Primary Antibody for WB - ABIN393532 : Bodenmann, Landolt: Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT. in Sleep 2010 (PubMed)
    Show all 5 references for ABIN393532

  3. Human Monoclonal COMT Primary Antibody for WB - ABIN1882224 : Zeng, Ye, Lu, Chua, Tan, Zhong: Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes. in Organic letters 2010 (PubMed)
    Show all 5 references for ABIN1882224

  4. Mouse (Murine) Monoclonal COMT Primary Antibody for BI, IF - ABIN968704 : Gogos, Morgan, Luine, Santha, Ogawa, Pfaff, Karayiorgou: Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 3 references for ABIN968704

  5. Human Polyclonal COMT Primary Antibody for WB - ABIN514522 : Hevir, Sinkovec, Rižner: Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT. in Molecular and cellular endocrinology 2010 (PubMed)

  6. Human Polyclonal COMT Primary Antibody for WB - ABIN2781821 : Shiels, Huang, Hoffman, Shugart, Bolton, Platz, Helzlsouer, Alberg: A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A). in Preventive medicine 2008 (PubMed)

More Antibodies against COMT Interaction Partners

Horse (Equine) Catechol-O-Methyltransferase (COMT) interaction partners

  1. An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.

Human Catechol-O-Methyltransferase (COMT) interaction partners

  1. our updated meta-analysis suggested that COMT Val158Met polymorphism could decrease the risk of Alzheimer disease in the Asian population, but not in the Caucasian or the overall population.

  2. COMT Val (158) Met may preferentially modulate nonverbal cognition following uncomplicated mild traumatic brain injury.

  3. No significant differences are found in the COMT gene polymorphism genotype distributions between cervical cancer patient and control groups.

  4. The results of this study confirm the impact of COMT genotype on frontal functions. They also strongly suggest that differences in frontal activity influence posterior brain regions related to a non-executive component of the task.

  5. Study demonstrate that adolescent and adult resting state networks are dose-dependently and diametrically affected by catechol-O-methyltransferase genotypes following a hypothetical model of dopamine function that follows an inverted U-shaped curve.

  6. the association of CYP1A1 (show CYP1A1 Antibodies) M1 (rs4646903) and COMT (rs4680) polymorphisms in 130 cervical cancer cases (c-cancer) and 179 controls, is reported.

  7. COMT polymorphisms influence obsessive-compulsive patients' features.

  8. These data clarify the importance of taking into account the combined effect of sex, hormonal status and COMT genetic variation.

  9. COMT polymorphism status affects threat cue reactivity at the visuocortical level

  10. Our study suggests that the COMT p.Val158Met polymorphism has a larger genetic contribution to tests of attention, cognitive flexibility and information processing speed at ages 43-56 than at ages 63-76.

Mouse (Murine) Catechol-O-Methyltransferase (COMT) interaction partners

  1. This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC (show CFP Antibodies)) and postero-parieto-temporal cortex of male, but not female adult mice.

  2. COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.

  3. COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function

  4. These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1 (show DTNBP1 Antibodies).

  5. The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.

  6. Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.

  7. COMT knockout mice were more impulsive compared with wild-type littermates.

  8. Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.

  9. decreased COMT activity was associated with some changes in feeding microstructure in rats and mice

  10. This study demonistrated that COMT deletion with elevated anxiety in females and suggest that this may be related to a heightened neuroendocrine response to acute stress in COMT KO mice.

COMT Antigen Profile

Protein Summary

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Gene names and symbols associated with COMT

  • catechol-O-methyltransferase (COMT) antibody
  • catechol-O-methyltransferase (comt) antibody
  • catechol-O-methyltransferase (comt.2) antibody
  • catechol-o-methyltransferase (Rv1703c) antibody
  • catechol-o-methyltransferase (Mb1729c) antibody
  • catechol O-methyltransferase-like (LOC100630273) antibody
  • catechol-O-methyltransferase (Comt) antibody
  • comt antibody
  • Comt1 antibody
  • D16Wsu103e antibody
  • D330014B15Rik antibody
  • mb-comt antibody
  • MGC154444 antibody
  • s-comt antibody

Protein level used designations for COMT

catechol-O-methyltransferase , catechol-o-methyltransferase , catechol O-methyltransferase, soluble form , catechol O-methyltransferase, membrane-bound form , catechol O-methyltransferase , O-methyltransferase , catechol-O-methyltransferase 1 , catecholamine-O-methyltransferase

GENE ID SPECIES
416783 Gallus gallus
458655 Pan troglodytes
549111 Xenopus (Silurana) tropicalis
549911 Xenopus (Silurana) tropicalis
779254 Xenopus laevis
885066 Mycobacterium tuberculosis H37Rv
1092683 Mycobacterium bovis AF2122/97
100033869 Equus caballus
100146509 Equus caballus
100630273 Equus caballus
1312 Homo sapiens
445450 Canis lupus familiaris
12846 Mus musculus
24267 Rattus norvegicus
618278 Bos taurus
100155530 Sus scrofa
Selected quality suppliers for anti-COMT (COMT) Antibodies
Did you look for something else?