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Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. Additionally we are shipping COMT Kits (30) and COMT Proteins (26) and many more products for this protein.
Showing 10 out of 183 products:
Human Polyclonal COMT Primary Antibody for ELISA, WB - ABIN185328
Tunbridge, Harrison, Weinberger: Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. in Biological psychiatry 2006
Show all 5 references for ABIN185328
Human Monoclonal COMT Primary Antibody for WB - ABIN393532
Bodenmann, Landolt: Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT. in Sleep 2010
Show all 5 references for ABIN393532
Human Monoclonal COMT Primary Antibody for WB - ABIN1882224
Zeng, Ye, Lu, Chua, Tan, Zhong: Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes. in Organic letters 2010
Show all 5 references for ABIN1882224
Mouse (Murine) Monoclonal COMT Primary Antibody for BI, IF - ABIN968704
Gogos, Morgan, Luine, Santha, Ogawa, Pfaff, Karayiorgou: Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. in Proceedings of the National Academy of Sciences of the United States of America 1998
Show all 3 references for ABIN968704
Human Polyclonal COMT Primary Antibody for WB - ABIN514522
Hevir, Sinkovec, Rižner: Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT. in Molecular and cellular endocrinology 2010
Human Polyclonal COMT Primary Antibody for WB - ABIN2781821
Shiels, Huang, Hoffman, Shugart, Bolton, Platz, Helzlsouer, Alberg: A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A). in Preventive medicine 2008
An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.
No statistically significant differences were found between cases and controls for the allele frequencies in five genes: TH, SLC18A2 (show Slc18a2 Antibodies), DRD1 (show DRD1 Antibodies), DRD3 (show DRD3 Antibodies) and COMT. Conversely, some alleles of the 12 sNPs from the DRD2 (show DRD2 Antibodies) locus and the 5 from the MAOA (show MAOA Antibodies) locus showed significant associations with excessive alcohol consumption.
These results indicate that the high-activity Val allele of the COMT Val(1)Met polymorphism is associated with increased alexithymic traits in patients with OCD. The present finding suggests that alexithymia is an endophenotype of OCD that is mediated by the COMT Val(1)Met polymorphism.
Emotional processing mediates the link between COMT Val158Met and aggression in young people with ADHD.
In three working memory tasks, we found no genotype-by-load interactions or main effects of COMT genotype on accuracy or reaction time.
Findings provide evidence of an epistatic interaction between polymorphisms acting within the dopamine system (specifically upon DRD4 (show DRD4 Antibodies) and COMT activity) and likelihood of comorbid substance abuse in women with bulimia-spectrum eating disturbances
Initial studies in neonates with in utero opiate exposure demonstrated that single-nucleotide polymorphisms in COMT gene were associated with improved outcomes in infants with Neonatal abstinence syndrome.
In a sample of Chinese Han adolescents, MAOA (show MAOA Antibodies) and COMT genes both interacted with positive parenting in their associations with reactive but not proactive aggression.
This study demonstrate the involvement of COMT Val158Met polymorphism in the framing effect in decision-making and suggest RSFC between OFC and amygdala as a neural mediator underlying this gene-behavior association.
Study found several associations between Catechol-O-Methyl Transferase (COMT val158met) and Dopamine D2 Receptor (DRD2 (show DRD2 Antibodies) G>T) genetic profile, motor performance, and sensorimotor adaptation. More importantly, we found that this association varies with age, task type, and engagement of implicit versus explicit learning processes
The aim of this study was to examine the relationship between COMT variants, plasma prolactin (show PRL Antibodies) level, and the therapeutic effectiveness of amisulpride treatment in patients with schizophrenia.
This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC (show CFP Antibodies)) and postero-parieto-temporal cortex of male, but not female adult mice.
COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.
COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function
These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1 (show DTNBP1 Antibodies).
The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.
Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.
COMT knockout mice were more impulsive compared with wild-type littermates.
Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.
decreased COMT activity was associated with some changes in feeding microstructure in rats and mice
This study demonistrated that COMT deletion with elevated anxiety in females and suggest that this may be related to a heightened neuroendocrine response to acute stress in COMT KO mice.
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
, catechol O-methyltransferase, soluble form
, catechol O-methyltransferase, membrane-bound form
, catechol O-methyltransferase
, catechol-O-methyltransferase 1