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anti-Catechol-O-Methyltransferase (COMT) Antibodies

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. Additionally we are shipping COMT Kits (30) and COMT Proteins (26) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
COMT 1312 P21964
COMT 12846 O88587
COMT 24267 P22734
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Top anti-COMT Antibodies at antibodies-online.com

Showing 10 out of 183 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-COMT Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Stomach 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB Staining of human testis lysate (35µg protein in RIPA buffer) with A) EB07357 (0.03µg/ml) and B) ABIN185328 (1µg/ml). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$326.89
Details
Human Goat Un-conjugated ELISA, WB Staining of human testis lysate (35µg protein in RIPA buffer) with ABIN185328 (0.2µg/ml). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$326.89
Details
Dog Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Mouse Mouse Un-conjugated BI, IF, WB Western blot analysis of COMT on a rat pituitary lysate. Lane 1: 1:10,000, lane 2: 1:20,000, lane 3: 1:40,000 dilution of the anti- COMT antibody. Immunofluorescence staining of rat cortical neurons. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Mouse Un-conjugated WB COMT Antibody (N-term)(Ascites) (ABIN1882224) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the COMT antibody detected the COMT protein (arrow). 0.1 mL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated EIA, ELISA, WB Staining of Human Testis lysate (35?g protein in RIPA buffer) with A) ABIN188559 (0.03?g/ml) and B) EB06595 (1?g/ml).  Primary incubation was 1 hour.  Detected by chemiluminescence. Western Blot: COMT Antibody [ABIN1885597] - Staining of human testis lysate (35ug protein in RIPA buffer) with Goat Anti-COMT (internal) (0.03ug/ml). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 5 to 7 Days
$408.19
Details
Human Mouse Un-conjugated WB Western Blot analysis of COMT expression in transfected 293T cell line by COMT monoclonal antibody (M01), clone 1G4-1A1. Lane 1: COMT transfected lysate(24.4 KDa). Lane 2: Non-transfected lysate. COMT monoclonal antibody (M01), clone 1G4-1A1 Western Blot analysis of COMT expression in A-431. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated WB COMT MaxPab polyclonal antibody. Western Blot analysis of COMT expression in human placenta. Western Blot analysis of COMT expression in transfected 293T cell line by COMT MaxPab polyclonal antibody.Lane 1: COMT transfected lysate(24.31 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 9 Days
$430.00
Details

COMT Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-COMT Antibodies

  1. Human Polyclonal COMT Primary Antibody for ELISA, WB - ABIN185328 : Tunbridge, Harrison, Weinberger: Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. in Biological psychiatry 2006 (PubMed)
    Show all 5 references for ABIN185328

  2. Human Monoclonal COMT Primary Antibody for WB - ABIN393532 : Bodenmann, Landolt: Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT. in Sleep 2010 (PubMed)
    Show all 5 references for ABIN393532

  3. Human Monoclonal COMT Primary Antibody for WB - ABIN1882224 : Zeng, Ye, Lu, Chua, Tan, Zhong: Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes. in Organic letters 2010 (PubMed)
    Show all 5 references for ABIN1882224

  4. Mouse (Murine) Monoclonal COMT Primary Antibody for BI, IF - ABIN968704 : Gogos, Morgan, Luine, Santha, Ogawa, Pfaff, Karayiorgou: Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 3 references for ABIN968704

  5. Human Polyclonal COMT Primary Antibody for WB - ABIN514522 : Hevir, Sinkovec, Rižner: Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT. in Molecular and cellular endocrinology 2010 (PubMed)

  6. Human Polyclonal COMT Primary Antibody for WB - ABIN2781821 : Shiels, Huang, Hoffman, Shugart, Bolton, Platz, Helzlsouer, Alberg: A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A). in Preventive medicine 2008 (PubMed)

More Antibodies against COMT Interaction Partners

Horse (Equine) Catechol-O-Methyltransferase (COMT) interaction partners

  1. An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.

Human Catechol-O-Methyltransferase (COMT) interaction partners

  1. No statistically significant differences were found between cases and controls for the allele frequencies in five genes: TH, SLC18A2 (show Slc18a2 Antibodies), DRD1 (show DRD1 Antibodies), DRD3 (show DRD3 Antibodies) and COMT. Conversely, some alleles of the 12 sNPs from the DRD2 (show DRD2 Antibodies) locus and the 5 from the MAOA (show MAOA Antibodies) locus showed significant associations with excessive alcohol consumption.

  2. These results indicate that the high-activity Val allele of the COMT Val(1)Met polymorphism is associated with increased alexithymic traits in patients with OCD. The present finding suggests that alexithymia is an endophenotype of OCD that is mediated by the COMT Val(1)Met polymorphism.

  3. Emotional processing mediates the link between COMT Val158Met and aggression in young people with ADHD.

  4. In three working memory tasks, we found no genotype-by-load interactions or main effects of COMT genotype on accuracy or reaction time.

  5. Findings provide evidence of an epistatic interaction between polymorphisms acting within the dopamine system (specifically upon DRD4 (show DRD4 Antibodies) and COMT activity) and likelihood of comorbid substance abuse in women with bulimia-spectrum eating disturbances

  6. Initial studies in neonates with in utero opiate exposure demonstrated that single-nucleotide polymorphisms in COMT gene were associated with improved outcomes in infants with Neonatal abstinence syndrome.

  7. In a sample of Chinese Han adolescents, MAOA (show MAOA Antibodies) and COMT genes both interacted with positive parenting in their associations with reactive but not proactive aggression.

  8. This study demonstrate the involvement of COMT Val158Met polymorphism in the framing effect in decision-making and suggest RSFC between OFC and amygdala as a neural mediator underlying this gene-behavior association.

  9. Study found several associations between Catechol-O-Methyl Transferase (COMT val158met) and Dopamine D2 Receptor (DRD2 (show DRD2 Antibodies) G>T) genetic profile, motor performance, and sensorimotor adaptation. More importantly, we found that this association varies with age, task type, and engagement of implicit versus explicit learning processes

  10. The aim of this study was to examine the relationship between COMT variants, plasma prolactin (show PRL Antibodies) level, and the therapeutic effectiveness of amisulpride treatment in patients with schizophrenia.

Mouse (Murine) Catechol-O-Methyltransferase (COMT) interaction partners

  1. This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC (show CFP Antibodies)) and postero-parieto-temporal cortex of male, but not female adult mice.

  2. COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.

  3. COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function

  4. These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1 (show DTNBP1 Antibodies).

  5. The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.

  6. Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.

  7. COMT knockout mice were more impulsive compared with wild-type littermates.

  8. Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.

  9. decreased COMT activity was associated with some changes in feeding microstructure in rats and mice

  10. This study demonistrated that COMT deletion with elevated anxiety in females and suggest that this may be related to a heightened neuroendocrine response to acute stress in COMT KO mice.

COMT Antigen Profile

Protein Summary

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Gene names and symbols associated with COMT

  • catechol-O-methyltransferase (COMT) antibody
  • catechol-O-methyltransferase (comt) antibody
  • catechol-O-methyltransferase (comt.2) antibody
  • catechol-o-methyltransferase (Rv1703c) antibody
  • catechol-o-methyltransferase (Mb1729c) antibody
  • catechol O-methyltransferase-like (LOC100630273) antibody
  • catechol-O-methyltransferase (Comt) antibody
  • comt antibody
  • Comt1 antibody
  • D16Wsu103e antibody
  • D330014B15Rik antibody
  • mb-comt antibody
  • MGC154444 antibody
  • s-comt antibody

Protein level used designations for COMT

catechol-O-methyltransferase , catechol-o-methyltransferase , catechol O-methyltransferase, soluble form , catechol O-methyltransferase, membrane-bound form , catechol O-methyltransferase , O-methyltransferase , catechol-O-methyltransferase 1 , catecholamine-O-methyltransferase

GENE ID SPECIES
416783 Gallus gallus
458655 Pan troglodytes
549111 Xenopus (Silurana) tropicalis
549911 Xenopus (Silurana) tropicalis
779254 Xenopus laevis
885066 Mycobacterium tuberculosis H37Rv
1092683 Mycobacterium bovis AF2122/97
100033869 Equus caballus
100146509 Equus caballus
100630273 Equus caballus
1312 Homo sapiens
445450 Canis lupus familiaris
12846 Mus musculus
24267 Rattus norvegicus
618278 Bos taurus
100155530 Sus scrofa
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