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Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. Additionally we are shipping COMT Kits (37) and COMT Proteins (26) and many more products for this protein.
Showing 10 out of 180 products:
Human Polyclonal COMT Primary Antibody for ELISA, WB - ABIN185328
Tunbridge, Harrison, Weinberger: Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. in Biological psychiatry 2006
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Human Monoclonal COMT Primary Antibody for WB - ABIN393532
Bodenmann, Landolt: Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT. in Sleep 2010
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Human Monoclonal COMT Primary Antibody for WB - ABIN1882224
Zeng, Ye, Lu, Chua, Tan, Zhong: Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes. in Organic letters 2010
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Mouse (Murine) Monoclonal COMT Primary Antibody for BI, IF - ABIN968704
Gogos, Morgan, Luine, Santha, Ogawa, Pfaff, Karayiorgou: Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. in Proceedings of the National Academy of Sciences of the United States of America 1998
Show all 3 references for ABIN968704
Human Polyclonal COMT Primary Antibody for WB - ABIN514522
Hevir, Sinkovec, Rižner: Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT. in Molecular and cellular endocrinology 2010
Human Polyclonal COMT Primary Antibody for WB - ABIN2781821
Shiels, Huang, Hoffman, Shugart, Bolton, Platz, Helzlsouer, Alberg: A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A). in Preventive medicine 2008
An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.
our updated meta-analysis suggested that COMT Val158Met polymorphism could decrease the risk of Alzheimer disease in the Asian population, but not in the Caucasian or the overall population.
COMT Val (158) Met may preferentially modulate nonverbal cognition following uncomplicated mild traumatic brain injury.
No significant differences are found in the COMT gene polymorphism genotype distributions between cervical cancer patient and control groups.
The results of this study confirm the impact of COMT genotype on frontal functions. They also strongly suggest that differences in frontal activity influence posterior brain regions related to a non-executive component of the task.
Study demonstrate that adolescent and adult resting state networks are dose-dependently and diametrically affected by catechol-O-methyltransferase genotypes following a hypothetical model of dopamine function that follows an inverted U-shaped curve.
the association of CYP1A1 (show CYP1A1 Antibodies) M1 (rs4646903) and COMT (rs4680) polymorphisms in 130 cervical cancer cases (c-cancer) and 179 controls, is reported.
COMT polymorphisms influence obsessive-compulsive patients' features.
These data clarify the importance of taking into account the combined effect of sex, hormonal status and COMT genetic variation.
COMT polymorphism status affects threat cue reactivity at the visuocortical level
Our study suggests that the COMT p.Val158Met polymorphism has a larger genetic contribution to tests of attention, cognitive flexibility and information processing speed at ages 43-56 than at ages 63-76.
This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC (show CFP Antibodies)) and postero-parieto-temporal cortex of male, but not female adult mice.
COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.
COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function
These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1 (show DTNBP1 Antibodies).
The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.
Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.
COMT knockout mice were more impulsive compared with wild-type littermates.
Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.
decreased COMT activity was associated with some changes in feeding microstructure in rats and mice
This study demonistrated that COMT deletion with elevated anxiety in females and suggest that this may be related to a heightened neuroendocrine response to acute stress in COMT KO mice.
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
, catechol O-methyltransferase, soluble form
, catechol O-methyltransferase, membrane-bound form
, catechol O-methyltransferase
, catechol-O-methyltransferase 1