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Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. Additionally we are shipping COMT Antibodies (174) and COMT Kits (37) and many more products for this protein.
Showing 10 out of 26 products:
Human COMT Protein expressed in Escherichia coli (E. coli) - ABIN666744
Cotton, Stoddard, Parson: Oxidative inhibition of human soluble catechol-O-methyltransferase. in The Journal of biological chemistry 2004
Show all 2 references for ABIN666744
An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.
The results of this study provided further evidence that 5-HTTLPR (show SLC6A4 Proteins) and COMT Val(158)Met genotypes influence the vulnerability for the development of anxiety disorders via different mechanisms.
the COMT rs4680 polymorphism is not associated with susceptibility to ovarian cancer.
ESR1 (show ESR1 Proteins) may be associated with low mineral osseous densitometry, while CYP17 (show CYP17A1 Proteins) and COMT gene polymorphisms were not associated with mineral osseous densitometry.
The SNPs of COMT V108/158M and ABCB1 (show ABCB1 Proteins) C3435T significantly influence pain perception in Chinese cancer patients.
on a sequence learning task in 161 Caucasian participants, the COMT polymorphism predicted the ability to switch flexibly between two sequences
The COMT gene rs4680 polymorphism was genotyped using a DNA sequence detection system. The heroin use status was evaluated for 5 years after discharged. the COMT rs4680 gene variants were different between relapse and abstinent groups.
Linear Regression showed COMT rs5993883 GG genotype predicted lower verbal learning (p = 0.0006) and memory (p = 0.0026) scores, and lower scores on a cognitive control(p = 0.004) in second generation antipsychotics treated pts (show PTS Proteins). with bipolar disorder.
The AA genotype and the A allele of rs4680 (COMT) appeared to be inversely associated with the risk of prostate cancer in adjusted models for both Afro-Caribbean and native African men
COMT Val158Met was not associated with frontal EEG asymmetry.
the COMT polymorphism affects white-matter microstructure, indexed by fractional anisotropy and mean diffusivity, of several white-matter tracts in the oldest age group (81-87 years)
This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC (show CFP Proteins)) and postero-parieto-temporal cortex of male, but not female adult mice.
COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.
COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function
These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1 (show DTNBP1 Proteins).
The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.
Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.
COMT knockout mice were more impulsive compared with wild-type littermates.
Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.
decreased COMT activity was associated with some changes in feeding microstructure in rats and mice
This study demonistrated that COMT deletion with elevated anxiety in females and suggest that this may be related to a heightened neuroendocrine response to acute stress in COMT KO mice.
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
, catechol O-methyltransferase, soluble form
, catechol O-methyltransferase, membrane-bound form
, catechol O-methyltransferase
, catechol-O-methyltransferase 1