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Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. Additionally we are shipping COMT Antibodies (184) and COMT Kits (30) and many more products for this protein.
Showing 10 out of 26 products:
Human COMT Protein expressed in Escherichia coli (E. coli) - ABIN666744
Cotton, Stoddard, Parson: Oxidative inhibition of human soluble catechol-O-methyltransferase. in The Journal of biological chemistry 2004
Show all 2 references for ABIN666744
An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.
No association of functional polymorphisms in the estrogen metabolism genes COMT with menstrual migraine.
genetic association studies in a population in Denmark: Data suggest that, compared to non-carriers of the COMT SNP rs4680 A allele, carriers/heterozygotes (AA/AG) report higher bone pressure pain tolerance threshold (i.e., less pain) by up to 23.8%.
genetic association studies in a population in Denmark: Data suggest that a reduced risk of death in morphine addiction is associated with an SNP in ABCB1 (show ABCB1 Proteins) (P-glycoprotein/ATP-binding cassette subfamily B member 1, rs9282564, AG/TT) and an SNP in COMT (catechol-O-methyltransferase, rs4680, AA) in the population studied.
COMT rs4680 influences individual differences in reward learning.
COMT Val158Met polymorphism is not associated with endometrial and ovarian cancer.
Whether COMT genotype indirectly influences global functional outcome through post-traumatic stress disorder remains to be determined
CYP2E1 (show CYP2E1 Proteins) rs2031920 and COMT rs4680 are not major contributors to lung cancer risk.
findings suggested that the COMT l58Val/Met polymorphism confer genetic susceptibility to lung cancer among women [Meta-Analysis]
No statistically significant differences were found between cases and controls for the allele frequencies in five genes: TH, SLC18A2 (show Slc18a2 Proteins), DRD1 (show DRD1 Proteins), DRD3 (show DRD3 Proteins) and COMT. Conversely, some alleles of the 12 sNPs from the DRD2 (show DRD2 Proteins) locus and the 5 from the MAOA (show MAOA Proteins) locus showed significant associations with excessive alcohol consumption.
These results indicate that the high-activity Val allele of the COMT Val(1)Met polymorphism is associated with increased alexithymic traits in patients with OCD. The present finding suggests that alexithymia is an endophenotype of OCD that is mediated by the COMT Val(1)Met polymorphism.
This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC (show CFP Proteins)) and postero-parieto-temporal cortex of male, but not female adult mice.
COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.
COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function
These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1 (show DTNBP1 Proteins).
The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.
Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.
COMT knockout mice were more impulsive compared with wild-type littermates.
Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.
decreased COMT activity was associated with some changes in feeding microstructure in rats and mice
This study demonistrated that COMT deletion with elevated anxiety in females and suggest that this may be related to a heightened neuroendocrine response to acute stress in COMT KO mice.
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
, catechol O-methyltransferase, soluble form
, catechol O-methyltransferase, membrane-bound form
, catechol O-methyltransferase
, catechol-O-methyltransferase 1