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Catechol-O-Methyltransferase Proteins (COMT)

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. Additionally we are shipping COMT Antibodies (181) and COMT Kits (37) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COMT 1312 P21964
COMT 12846 O88587
COMT 24267 P22734
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Top COMT Proteins at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$583.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

COMT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus) ,

Top referenced COMT Proteins

  1. Human COMT Protein expressed in Escherichia coli (E. coli) - ABIN666744 : Cotton, Stoddard, Parson: Oxidative inhibition of human soluble catechol-O-methyltransferase. in The Journal of biological chemistry 2004 (PubMed)
    Show all 2 references for ABIN666744

More Proteins for Catechol-O-Methyltransferase (COMT) Interaction Partners

Horse (Equine) Catechol-O-Methyltransferase (COMT) interaction partners

  1. An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.

Human Catechol-O-Methyltransferase (COMT) interaction partners

  1. our updated meta-analysis suggested that COMT Val158Met polymorphism could decrease the risk of Alzheimer disease in the Asian population, but not in the Caucasian or the overall population.

  2. COMT Val (158) Met may preferentially modulate nonverbal cognition following uncomplicated mild traumatic brain injury.

  3. No significant differences are found in the COMT gene polymorphism genotype distributions between cervical cancer patient and control groups.

  4. The results of this study confirm the impact of COMT genotype on frontal functions. They also strongly suggest that differences in frontal activity influence posterior brain regions related to a non-executive component of the task.

  5. Study demonstrate that adolescent and adult resting state networks are dose-dependently and diametrically affected by catechol-O-methyltransferase genotypes following a hypothetical model of dopamine function that follows an inverted U-shaped curve.

  6. the association of CYP1A1 (show CYP1A1 Proteins) M1 (rs4646903) and COMT (rs4680) polymorphisms in 130 cervical cancer cases (c-cancer) and 179 controls, is reported.

  7. COMT polymorphisms influence obsessive-compulsive patients' features.

  8. These data clarify the importance of taking into account the combined effect of sex, hormonal status and COMT genetic variation.

  9. COMT polymorphism status affects threat cue reactivity at the visuocortical level

  10. Our study suggests that the COMT p.Val158Met polymorphism has a larger genetic contribution to tests of attention, cognitive flexibility and information processing speed at ages 43-56 than at ages 63-76.

Mouse (Murine) Catechol-O-Methyltransferase (COMT) interaction partners

  1. This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC (show CFP Proteins)) and postero-parieto-temporal cortex of male, but not female adult mice.

  2. COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.

  3. COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function

  4. These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1 (show DTNBP1 Proteins).

  5. The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.

  6. Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.

  7. COMT knockout mice were more impulsive compared with wild-type littermates.

  8. Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.

  9. decreased COMT activity was associated with some changes in feeding microstructure in rats and mice

  10. This study demonistrated that COMT deletion with elevated anxiety in females and suggest that this may be related to a heightened neuroendocrine response to acute stress in COMT KO mice.

COMT Protein Profile

Protein Summary

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Gene names and symbols associated with COMT

  • catechol-O-methyltransferase (COMT)
  • catechol-O-methyltransferase (comt)
  • catechol-O-methyltransferase (comt.2)
  • catechol-o-methyltransferase (Rv1703c)
  • catechol-o-methyltransferase (Mb1729c)
  • catechol O-methyltransferase-like (LOC100630273)
  • catechol-O-methyltransferase (Comt)
  • comt protein
  • Comt1 protein
  • D16Wsu103e protein
  • D330014B15Rik protein
  • mb-comt protein
  • MGC154444 protein
  • s-comt protein

Protein level used designations for COMT

catechol-O-methyltransferase , catechol-o-methyltransferase , catechol O-methyltransferase, soluble form , catechol O-methyltransferase, membrane-bound form , catechol O-methyltransferase , O-methyltransferase , catechol-O-methyltransferase 1 , catecholamine-O-methyltransferase

GENE ID SPECIES
416783 Gallus gallus
458655 Pan troglodytes
549111 Xenopus (Silurana) tropicalis
549911 Xenopus (Silurana) tropicalis
779254 Xenopus laevis
885066 Mycobacterium tuberculosis H37Rv
1092683 Mycobacterium bovis AF2122/97
100033869 Equus caballus
100146509 Equus caballus
100630273 Equus caballus
1312 Homo sapiens
445450 Canis lupus familiaris
12846 Mus musculus
24267 Rattus norvegicus
618278 Bos taurus
100155530 Sus scrofa
Selected quality suppliers for COMT Proteins (COMT)
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