You are viewing an incomplete version of our website. Please click to reload the website as full version.

Catechol-O-Methyltransferase Proteins (COMT)

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. Additionally we are shipping COMT Antibodies (183) and COMT Kits (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COMT 1312 P21964
COMT 12846 O88587
COMT 24267 P22734
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top COMT Proteins at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$583.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

COMT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus) ,

Top referenced COMT Proteins

  1. Human COMT Protein expressed in Escherichia coli (E. coli) - ABIN666744 : Cotton, Stoddard, Parson: Oxidative inhibition of human soluble catechol-O-methyltransferase. in The Journal of biological chemistry 2004 (PubMed)
    Show all 2 references for ABIN666744

More Proteins for Catechol-O-Methyltransferase (COMT) Interaction Partners

Horse (Equine) Catechol-O-Methyltransferase (COMT) interaction partners

  1. An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.

Human Catechol-O-Methyltransferase (COMT) interaction partners

  1. COMT Val158Met polymorphism is not associated with endometrial and ovarian cancer.

  2. Whether COMT genotype indirectly influences global functional outcome through post-traumatic stress disorder remains to be determined

  3. CYP2E1 (show CYP2E1 Proteins) rs2031920 and COMT rs4680 are not major contributors to lung cancer risk.

  4. findings suggested that the COMT l58Val/Met polymorphism confer genetic susceptibility to lung cancer among women [Meta-Analysis]

  5. No statistically significant differences were found between cases and controls for the allele frequencies in five genes: TH, SLC18A2 (show Slc18a2 Proteins), DRD1 (show DRD1 Proteins), DRD3 (show DRD3 Proteins) and COMT. Conversely, some alleles of the 12 sNPs from the DRD2 (show DRD2 Proteins) locus and the 5 from the MAOA (show MAOA Proteins) locus showed significant associations with excessive alcohol consumption.

  6. These results indicate that the high-activity Val allele of the COMT Val(1)Met polymorphism is associated with increased alexithymic traits in patients with OCD. The present finding suggests that alexithymia is an endophenotype of OCD that is mediated by the COMT Val(1)Met polymorphism.

  7. Emotional processing mediates the link between COMT Val158Met and aggression in young people with ADHD.

  8. In three working memory tasks, we found no genotype-by-load interactions or main effects of COMT genotype on accuracy or reaction time.

  9. Findings provide evidence of an epistatic interaction between polymorphisms acting within the dopamine system (specifically upon DRD4 (show DRD4 Proteins) and COMT activity) and likelihood of comorbid substance abuse in women with bulimia-spectrum eating disturbances

  10. Initial studies in neonates with in utero opiate exposure demonstrated that single-nucleotide polymorphisms in COMT gene were associated with improved outcomes in infants with Neonatal abstinence syndrome.

Mouse (Murine) Catechol-O-Methyltransferase (COMT) interaction partners

  1. This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC (show CFP Proteins)) and postero-parieto-temporal cortex of male, but not female adult mice.

  2. COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.

  3. COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function

  4. These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1 (show DTNBP1 Proteins).

  5. The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.

  6. Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.

  7. COMT knockout mice were more impulsive compared with wild-type littermates.

  8. Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.

  9. decreased COMT activity was associated with some changes in feeding microstructure in rats and mice

  10. This study demonistrated that COMT deletion with elevated anxiety in females and suggest that this may be related to a heightened neuroendocrine response to acute stress in COMT KO mice.

COMT Protein Profile

Protein Summary

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Gene names and symbols associated with COMT

  • catechol-O-methyltransferase (COMT)
  • catechol-O-methyltransferase (comt)
  • catechol-O-methyltransferase (comt.2)
  • catechol-o-methyltransferase (Rv1703c)
  • catechol-o-methyltransferase (Mb1729c)
  • catechol O-methyltransferase-like (LOC100630273)
  • catechol-O-methyltransferase (Comt)
  • comt protein
  • Comt1 protein
  • D16Wsu103e protein
  • D330014B15Rik protein
  • mb-comt protein
  • MGC154444 protein
  • s-comt protein

Protein level used designations for COMT

catechol-O-methyltransferase , catechol-o-methyltransferase , catechol O-methyltransferase, soluble form , catechol O-methyltransferase, membrane-bound form , catechol O-methyltransferase , O-methyltransferase , catechol-O-methyltransferase 1 , catecholamine-O-methyltransferase

GENE ID SPECIES
416783 Gallus gallus
458655 Pan troglodytes
549111 Xenopus (Silurana) tropicalis
549911 Xenopus (Silurana) tropicalis
779254 Xenopus laevis
885066 Mycobacterium tuberculosis H37Rv
1092683 Mycobacterium bovis AF2122/97
100033869 Equus caballus
100146509 Equus caballus
100630273 Equus caballus
1312 Homo sapiens
445450 Canis lupus familiaris
12846 Mus musculus
24267 Rattus norvegicus
618278 Bos taurus
100155530 Sus scrofa
Selected quality suppliers for COMT Proteins (COMT)
Did you look for something else?