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anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) Antibodies

Associates with the cytoplasmic domain of a variety of cadherins. Additionally we are shipping Catenin (Cadherin-Associated Protein), alpha 1, 102kDa Kits (35) and Catenin (Cadherin-Associated Protein), alpha 1, 102kDa Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CTNNA1 12385 P26231
CTNNA1 1495 P35221
CTNNA1 307505  
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Top anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa Antibodies at antibodies-online.com

Showing 10 out of 134 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Western blot analysis of extracts from HeLa cells, using Catenin-alpha Antibody  . The lane on the right is treated with the synthesized peptide. 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN185626 (1µg/ml) staining of human colon lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Dog Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB 0.1 mL Log in to see 6 to 8 Days
$308.00
Details
Human Rabbit Un-conjugated WB 0.1 mL Log in to see 6 to 8 Days
$357.50
Details
Chicken Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of alpha-Catenin on a human endothelial cell lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the anti- alpha-Catenin antibody. Immunofluorescence staining of HeLa cells. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Chicken Mouse Un-conjugated IF, IP, WB Western blot analysis of alpha-Catenin on a human endothelial cell lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the anti- alpha-Catenin antibody. Immunofluorescence staining of HeLa cells. 150 μg Log in to see 5 to 6 Days
$371.97
Details
Dog Mouse Un-conjugated EIA, IF, IP, WB 0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Mouse Un-conjugated FACS, IF, IP, WB   0.1 mg Log in to see 6 to 8 Days
$489.50
Details

CTNNA1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa Antibodies

  1. Chicken Monoclonal CTNNA1 Primary Antibody for IF, IP - ABIN967812 : Baki, Marambaud, Efthimiopoulos, Georgakopoulos, Wen, Cui, Shioi, Koo, Ozawa, Friedrich, Robakis: Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 5 references for ABIN967812

  2. Chicken Monoclonal CTNNA1 Primary Antibody for IF, IP - ABIN967813 : Hirano, Kimoto, Shimoyama, Hirohashi, Takeichi: Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization. in Cell 1992 (PubMed)
    Show all 5 references for ABIN967813

  3. Human Polyclonal CTNNA1 Primary Antibody for WB - ABIN401554 : Lipinski, Yuan: A cellular response to an internal energy crisis. in Cell 2005 (PubMed)
    Show all 4 references for ABIN401554

  4. Human Polyclonal CTNNA1 Primary Antibody for WB - ABIN319361 : Daneman, Barres: The blood-brain barrier--lessons from moody flies. in Cell 2005 (PubMed)
    Show all 4 references for ABIN319361

  5. Human Polyclonal CTNNA1 Primary Antibody for EIA, IHC (p) - ABIN1449661 : Shimoyama, Nagafuchi, Fujita, Gotoh, Takeichi, Tsukita, Hirohashi: Cadherin dysfunction in a human cancer cell line: possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness. in Cancer research 1992 (PubMed)
    Show all 2 references for ABIN1449661

  6. Human Polyclonal CTNNA1 Primary Antibody for EIA, WB - ABIN452886 : Inge, Rajasekaran, Wolle, Barwe, Ryazantsev, Ewing, Isaacs, Rajasekaran: alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling. in Molecular cancer therapeutics 2008 (PubMed)
    Show all 2 references for ABIN452886

  7. Dog (Canine) Polyclonal CTNNA1 Primary Antibody for WB - ABIN374681 : Lynch, Grady, Suriano, Huntsman: Gastric cancer: new genetic developments. in Journal of surgical oncology 2005 (PubMed)
    Show all 2 references for ABIN374681

  8. Human Monoclonal CTNNA1 Primary Antibody for FACS, IF - ABIN1105689 : Johnson, Lewis, Li, Wahl, Soler, Knudsen, Wheelock: P- and E-cadherin are in separate complexes in cells expressing both cadherins. in Experimental cell research 1993 (PubMed)
    Show all 2 references for ABIN1105689

More Antibodies against Catenin (Cadherin-Associated Protein), alpha 1, 102kDa Interaction Partners

Fruit Fly (Drosophila melanogaster) Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) interaction partners

  1. Increased Rap1 (show TERF2IP Antibodies) activity restricts epithelial invagination in an alpha-catenin-dependent manner.

  2. alpha-Cat mutant phenotype can be rescued by the expression of a DE-cadherin::alpha-Catenin fusion protein, which argues against an essential cytosolic, cadherin-independent role of Drosophila alpha-Catenin

  3. alpha-catenin and p120(ctn (show CTNND1 Antibodies)) are key players in a mechanism of recruiting Rho1 to its sites of action.

Zebrafish Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) interaction partners

  1. Depletion of alphaE-catenin caused a defect in radial intercalation that was associated with decreased cell-cell adhesion, in a similar manner to E-cadherin (show CDH1 Antibodies) depletion. Depletion of alphaE-catenin also caused deep cells to have plasma membrane blebbing.

Mouse (Murine) Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) interaction partners

  1. alphaE-catenin inhibits beta4 integrin-mediated activation of SRC (show SRC Antibodies) tyrosine kinase (show TYRO3 Antibodies)

  2. E-cadherin (show CDH1 Antibodies)/alphaE-catenin chimeras used previously do not mimic alphaE-catenin in the native CCC, and imply that both CCC-bound monomer and cytosolic homodimer alphaE-catenin are required for strong cell-cell adhesion.

  3. Loss of alpha-catenin elicits a cholestatic response and impairs liver regeneration

  4. alphaE-catenin binding to filamentous actin favors assembly of unbranched filament bundles that are protected from severing over more dynamic, branched filament arrays.

  5. Fusing VE-cadherin (show CDH5 Antibodies) to alpha-catenin presents a mutation, which leads to embryonic lethality, due to a lack of fetal liver hematopoiesis and severe lymphedema but no detectable defects in blood vessel formation and remodeling.

  6. alphaE-catenin recruits vinculin to adherens junctions more effectively than alphaN-catenin, partly because of its higher affinity for actin filaments.

  7. our results show that alpha-catenin-mediated cell adhesion and cell organization are important for the fissure closure in mice, and further suggest that genes that regulate cell adhesion may underlie certain coloboma cases in humans

  8. alpha-Catenin and vinculin (show VCL Antibodies) cooperate to promote high E-cadherin (show CDH1 Antibodies)-based adhesion strength

  9. alpha-catenin, previously implicated in tumor suppression and cell density sensing in the skin, is an upstream negative regulator of Yap1 (show YAP1 Antibodies); alpha-catenin controls Yap1 (show YAP1 Antibodies) activity and phosphorylation by modulating its interaction with 14-3-3 (show YWHAQ Antibodies) and PP2A (show PPP2R2B Antibodies) phosphatase.

  10. Data show that alphaE-catenin D3 binds strongly to vinculin (show VCL Antibodies), whereas larger fragments and full-length alphaE-catenin bind approximately 1,000-fold more weakly.

Human Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) interaction partners

  1. alpha- and beta-catenins may be important in the early stages of phyllodes tumours development, while E-cadherin (show CDH1 Antibodies) may be required for malignant development

  2. This work identified alpha-catenin as another molecule in addition to E- and P-cadherin that were targeted to inactivate homotypic cell-in-cell structures formation in human tumor cells.

  3. Progressive loss of e-cadherin (show CDH1 Antibodies)/alpha-catenin expression is associated with an aggressive phenotype (low differentiation, increased metastatic activity/advanced stage) in thyroid carcinomas.

  4. study identifies CTNNA1 gene variants as a cause of macular dystrophy, indicates that CTNNA1 is involved in maintaining RPE (show RPE Antibodies) integrity

  5. The results demonstrate a Fas (show FAS Antibodies)-mediated apoptotic signaling pathway that is enhanced by the age-dependent loss of alpha(E)-catenin in renal tubule epithelial cells.

  6. Actin-dependent CTNNA1 clustering is a unique molecular mechanism mediating both integrity and reassembly of the cell-cell adhesive interface formed through weak cis (show CISH Antibodies)- and trans-intercadherin interactions.

  7. alpha-catenin is a reversible, stretch-activatable sensor that mechanically links cadherin complexes and actin and is an indispensable player in cadherin-specific mechanotransduction at intercellular junctions.

  8. alpha-catenin functions as a tumor suppressor in E-cadherin (show CDH1 Antibodies)-negative basal like breast cancer cells by inhibiting NF-kappaB (show NFKB1 Antibodies) signaling.

  9. CTNNA1 hypermethylation was detected in three out of four with isolated del(5q), one with trisomy 11, one with monosomy 7, one out of four with del(20q), and one out of seven with complex abnormalities, but in none with trisomy 8.

  10. CTNNA1 methylation is a recurrent event but has no influence on prognosis in acute myeloid leukemia (show BCL11A Antibodies)

Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) Antigen Profile

Protein Summary

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Gene names and symbols associated with CTNNA1

  • catenin (cadherin-associated protein), alpha 1, 102kDa (CTNNA1) antibody
  • alpha Catenin (alpha-Cat) antibody
  • alpha Catenin (Dgrialpha-Cat) antibody
  • catenin alpha-1 (Tsp_10127) antibody
  • catenin (cadherin-associated protein), alpha 1, 102kDa (ctnna1) antibody
  • catenin (cadherin associated protein), alpha 1 (Ctnna1) antibody
  • catenin (cadherin-associated protein), alpha 1 (ctnna1) antibody
  • catenin (cadherin-associated protein), alpha 1, 102kDa (Ctnna1) antibody
  • catenin (cadherin-associated protein), alpha 2 (CTNNA2) antibody
  • 2010010M04Rik antibody
  • a-cat antibody
  • AA517462 antibody
  • AI988031 antibody
  • Alpha-Cat antibody
  • alpha-catenin antibody
  • alpha-ctn antibody
  • alphacat antibody
  • CAP102 antibody
  • Catna1 antibody
  • CG17947 antibody
  • CT39986 antibody
  • ctnna antibody
  • CTNNA1 antibody
  • Dalpha-cat antibody
  • DalphaC antibody
  • Dalphacat antibody
  • DgriGH19548 antibody
  • dgri_GLEANR_3829 antibody
  • Dmcatp antibody
  • Dmel\\CG17947 antibody
  • GH19548 antibody

Protein level used designations for CTNNA1

CG17947-PA , D-alpha-catenin , Dalpha-Catenin , Dalpha-cadherin , DalphaCatenin , a-catenin , alpha catenin , alpha-Cat-PA , alpha-Catenin , alphaCatenin , catenin alpha 1 subunit , catenin alpha-1 , DgriGH19548-PA , Dgrialpha-Cat-PA , GH19548-PA , catenin (cadherin-associated protein), alpha 1, 102kDa , catenin alpha-1-like , 102 kDa cadherin-associated protein , CAP102 , alpha E catenin , alpha E-catenin , alpha(E)-catenin , cadherin associated protein , catenin alpha 1 , [a]E-catenin , alpha-E-catenin , alpha-catenin , alphaE-catenin , cadherin-associated protein,102kDa , renal carcinoma antigen NY-REN-13 , catenin (cadherin associated protein), alpha 1 , catenin, alpha 1

GENE ID SPECIES
100072548 Equus caballus
40517 Drosophila melanogaster
450165 Pan troglodytes
574385 Macaca mulatta
6563215 Drosophila grimshawi
10905794 Trichinella spiralis
100020276 Monodelphis domestica
100091564 Ornithorhynchus anatinus
100407624 Callithrix jacchus
100453792 Pongo abelii
100483944 Ailuropoda melanoleuca
100538100 Danio rerio
100550456 Meleagris gallopavo
12385 Mus musculus
30741 Danio rerio
1495 Homo sapiens
474698 Canis lupus familiaris
307505 Rattus norvegicus
416184 Gallus gallus
100523778 Sus scrofa
526848 Bos taurus
100328952 Oryctolagus cuniculus
483088 Canis lupus familiaris
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